I-Alpha-ketoglutaric acid iyinto etholakala ngokwemvelo emzimbeni womuntu. Futhi etholakalayo kwifomu lokuxhaswa kokudla, i-alpha-ketoglutaric acid idlala indima ebalulekile emjikelezweni weKrebs (uchungechunge lwezenzo zamakhemikhali ezihilelekile ekukhiqizeni amandla kagesi). Izithako ze-Alpha-ketoglutaric acid zithi zinikeza izinzuzo ezihlukahlukene zezempilo.
I-Alpha-ketoglutaric acid nayo ikhona ngohlobo lwakasawoti, njengento ebizwa nge-alpha-ketoglutarate.
I-Alpha-ketoglutarate ihilelekile ekubunjweni kwe-glutamine, i-amino acid edingekayo kumaprotheni synthesis kanye nokusebenza kahle kwesistimu yomzimba.
Ukusetshenziswa
I-Alpha-ketoglutaric acid ivame ukukhulunywa ngokuthuthukisa ukusebenza kwezemidlalo. Abanye abaxhasi bezokwelapha abathile bathi ukusetshenziswa kwe-alpha-ketoglutaric acid kungasiza ekuvuseleleni ukukhiqizwa komzimba kwamaprotheni, ukuqinisa izinga lokushukela egazini ngesikhathi sokuvivinya umzimba, nokuthuthukisa ukukhuthazela kokuzivocavoca.
Eminye imithi, i-alpha-ketoglutaric acid nayo kuthiwa ukusiza ngezinkinga zempilo ezilandelayo:
- ukutheleleka kwamagciwane
- i-cataracts
- isifo sezinso
- imvubelo yesifo
Izinzuzo
Nakuba ucwaningo ngemiphumela yezempilo lwe-alpha-ketoglutaric acid lukhawulelwe kakhulu, ucwaningo oluthile luveza ukuthi i-alpha-ketoglutarate inganikeza izinzuzo ezithile zezempilo. Nakhu ukubuka okutholakala okuyinhloko kwezifundo ezikhona:
1) i-Hemodialysis
I-Alpha-ketoglutarate ingaba yinzuzo ethile kubantu abalawulwa i-hemodialysis.
Esicwaningweni esashicilelwe encwadini ethi Nephron ngo-1996, abacwaningi bathola ukuthi ukuphatha inhlanganisela ye-alpha-ketoglutarate ne-calcium carbonate ezigulini ze-hemodialysis kwasiza ekukhuliseni umthamo we-amino acid kanye nokunciphisa i-hyperphosphatemia (isimo esiboniswe amazinga angaphakanyisiwe e-phosphate egazini).
2) Ukuhlinzwa Kwezinhliziyo
I-Alpha-ketoglutarate ingasiza ekuthuthukiseni umsebenzi wezinso phakathi kweziguli ezenziwa ukuhlinzwa kwengqondo, ngokusho kocwaningo olwenziwa ngo-1998 oluvela ku- Annals of Thoracic Surgery . Ucwaningo lwabandakanya abantu abangu-22 abanezinso ezivamile zezinso ngaphambi kokuba baphethwe inhliziyo. Kulezi ziguli, abantu abangu-11 bathola ukumnika okufakwe ku-alpha-ketoglutarate ngehora ngemuva kokuhlinzwa kwabo. Imiphumela yokufundwa ibonisa ukuthi i-alpha-ketoglutarate ingathuthukisa ukugeleza kwegazi ezintsheni.
3) Ubude besikhathi eside
Ucwaningo lwango-2014 olushicilelwe ku- Nature lukhombisa ukuthi i-alpha-ketoglutarate ingabonisa isithembiso ekukhuliseni isikhathi eside. Ekuvivinyweni kwe-neatode worm ze- Caenorhabditis elegans , abalobi bokucwaninga banqume ukuthi i-alpha-ketoglutarate iphazamise ukukhiqizwa kwamandla weselula futhi imlingisa imiphumela yokudla okuncane kakhulu kwamakholori, okuye kwaboniswa ukwandisa isikhathi sokuphila kwezilwane ezithile. Ngokusho kwabalobi bokucwaninga, i-alpha-ketoglutarate yakhulisa isikhathi sokuphila kwezimpethu eziphathwe cishe ngamaphesenti angu-50 phezu kokulawulwa okungaphenduliwe. Ucwaningo olwengeziwe luyadingeka ukuze ubone ukuthi iziphi izakhi ezizobe zikhona kubantu.
Amapulangwe
Ngenxa yokuntuleka kocwaningo, akukho okuncane okukwaziwa ngokuphepha kokusetshenziswa isikhathi eside noma okuvamile kweziqu eziqukethe i-alpha-ketoglutaric acid.
Kodwa-ke, kunokukhathazeka okuthile ukuthi ukusetshenziswa kwe-alpha-ketoglutaric acid kungacasula isifo kanye / noma ukucasula isisu.
Kubalulekile ukukhumbula ukuthi ama-supplements awazange ahlolwe ukuphepha kanye nezondlo zokudla ngokuvamile azihambisani nomthetho. Kwezinye izimo, umkhiqizo ungase ulethe ukulinganisa okungafani nesilinganiso esicacisiwe semifino ngayinye. Kwezinye izimo, umkhiqizo ungangcoliswa nezinye izinto ezifana nezensimbi. Futhi, ukuphepha kwezidakamizwa kwabesifazane abakhulelwe, omama abahlengikazi, izingane, nalabo abanezimo zezokwelapha noma abaphuza imishanguzo azange zisungulwe.
Ungathola amathiphu engeziwe okusebenzisa izithako lapha .
Ezinye izindlela
Ezinye izindlela zokwelapha zemvelo zingase zisebenzise ekuthuthukiseni ukusebenza kwezemidlalo. Ngokwesibonelo, ucwaningo oluthile lubonisa ukuthi i-branched-chain chain amino acid ingasiza ekuthuthukiseni ukusebenza komzimba nokuvimbela ukukhathala ngesikhathi sokuzivocavoca.
Ngaphezu kwalokho, ukutholakala kwe-phosphatidylserine kuye kwatholakala ukuthi kukhuliswe amandla okuzivocavoca, futhi kunciphise ukuhlushwa kwemisipha futhi kuvikele ukwanda kwamazinga e-cortisol (i-hormone ekhishwe ngesikhathi sokucindezeleka) okuvame ukuphumela ekuqedeni ngokweqile.
Kukhona nobufakazi bokuthi i-creatine ingathuthukisa ukusebenza ngokuzikhandla okukhulu, imisebenzi emifushane (njengokunciphisa isisindo kanye ne-sprinting).
Lapho Uzoyithola khona
Etholakala ukuthengwa ku-intanethi, i-alpha-ketoglutaric acid idayiswa eziningi ezitolo zokudla zemvelo, izitolo zokuthengisa izidakamizwa kanye nezitolo ezitholakalayo ezisekelweni zokudla.
Izwi elivela
Ngenxa yokucwaninga okulinganiselwe, kusheshe kakhulu ukutusa i-alpha-ketoglutaric acid nganoma yisiphi isimo. Kubalulekile ukuqaphela ukuthi ukuzitholela isimo sezempilo nge-alpha-ketoglutaric acid futhi ukugwema noma ukubambezela ukunakekelwa okujwayelekile kungaba nemiphumela emibi. Uma ucabangela ukuyisebenzisa, qiniseka ukuthi uxhumana nodokotela wakho.
Imithombo
U-X, u-Pai Wami, u-Vergnes L, u-Hwang H, u-Deng G, u-Diep S, u-Lomenick B, i-VS Meli, i-Monsalve GC, i-Hu E, i-Whelan SA, i-Wang JX, i-Jung G, i-Solis GM, i- Fazlollahi F, i-Kaweeteerawat C, Quad A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, UJung ME, u-Frand AR, i-Huang J. "I-α-ketoglutarate ye-metabolite ikhulisa ukuphila ngokuvimbela i-ATP synthase ne-TOR." Imvelo. 2014; 509 (7500). dx.doi.org/10.1038/nature13264
Jeppsson A, Ekroth R, Friberg P, Kirnö K, Milocco I, Nilsson FN, Svensson S, J. J. Wernerman "Imiphumela emibi ye-alpha-ketoglutarate ngemva kokusebenza kwe-coronary." U-Ann Thorac Surg. 1998 Mar; 65 (3): 684-90.
Riedel E, Nündel M, Hampl H. "Uhlelo lokusebenza lwe-Alpha-Ketoglutarate ezigulini ze-hemodialysis lenza ngcono i-amino acid metabolism." Nefroni. 1996; 74 (2): 261-5.
Ukuziphendulela: Ulwazi oluqukethwe kule sayithi luhloswe ngezinjongo zemfundo kuphela futhi aluthathi iseluleko, ukuxilongwa noma ukwelashwa ngudokotela olayisensi. Akuhloselwe ukumboza zonke izinyathelo zokuqapha, ukusebenzisana kwezidakamizwa, izimo noma imiphumela emibi. Kufanele ufune ukunakekelwa okusheshayo kwezokwelapha kunoma yiziphi izinkinga zezempilo bese uthintana nodokotela wakho ngaphambi kokusebenzisa enye imithi noma wenze ushintsho ohlelweni lwakho.