Yini eyenza ihluke?
I-Zorvolex iyi-dose ephansi, ifomu lokuqeda okusheshayo lika-diclofenac, i- NSAID (izidakamizwa ezingekho ukuvuvukala). Kwavunyelwa ukwelashwa ubuhlungu be- osteoarthritis ngo-2014. Yini eyenza ihluke kwezinye izinhlobo zama-diclofenac namanye ama-NSAID?
I-Zorvolex, eyakhiwe yi-Iroko Pharmaceuticals, LLC, yavunyelwa ngaphambilini ukuphathwa komnene kuya ekunciphiseni ubuhlungu obukhulu kubantu abadala.
Ukwamukelwa kobuhlungu be-osteoarthritis kuyinkomba eyengeziwe, Ngoba akuyona yonke imithi kanye nokwelashwa okuphumelelayo ngokufanayo kunoma yimuphi umuntu onikeziwe, wamukelwa njengendlela entsha yokugula kweziguli ze-osteoarthritis.
Izinhlobo zeDiclofenac
I-Zorvolex ihluke kanjani ku-diclofenac ejwayelekile kanye nefomu legama lomkhiqizo, i- Voltaren , okuyihlobo le-diclofenac, ne-diclofenac ejwayelekile? I-Zorvolex ihlelwe nge-submicron izinhlayiya ze-diclofenac. Izinhlayiyana ze-submicron zingaphansi kwama-20 izikhathi ezincane kunesayizi etholakala kwezinye izidakamizwa ze-diclofenac. Izinhlayiyana ze-submicron, ezithuthukisiwe zisebenzisa i-SoluMatrix Fine Particle Technology, vumela ukuthi izidakamizwa zichithe ngokushesha. I-Zorvolex yi- NSAID yokuqala ye-dose ephansi (isidakamizwa esingavumelani nokuvuvukala) esasungulwa esebenzisa i-SoluMatrix Fine Particle Technology evunyelwe yi-FDA.
Kudinga ama-NSAID aphansi
I-NSAID yesilinganiso esincane isiza ukubhekana nezixwayiso ze-FDA nezincomo.
Eminyakeni embalwa eyedlule, i-FDA ivuselelwe futhi yanda izixwayiso kuzo zonke izidakamizwa ze-NSAID. Kwachazwa ngokucacile ukuthi ama-NSAID ahlotshaniswa nenengozi eyanda kakhulu yezinkinga zenhliziyo (isb., Ukuhlasela kwenhliziyo nokushaya kwesisu) kanye nokuphuma kwegazi emathunjini . Cishe ngaleso sikhathi, ama-NSAID amabili e-COX-2 akhethiwe - i- Vioxx (rofecoxib) ne- Bextra (valdecoxib) - ayidonswa emakethe, kodwa iningi lahlala.
I-FDA ibuye ibuye yabelisa odokotela ukuba bayinike (kanye neziguli okufanele zizisebenzise) umthamo ophansi kunawo wonke we-NSAID okwesikhathi esiseduze kunokwenzeka, ngenkathi ucabangela umgomo wokwelapha.
Ukuphatha / Isilinganiso
Umthamo ophakanyisiwe weZorvolex (umuthi womlomo) wezinhlungu ze-osteoarthritis ungama-35 mg. kathathu ngosuku. (Qaphela: Ama-capsules ama-Zorvolex awashintshaniswa nama-voltaren noma amaphilisi ajwayelekile e-diclofenac. Umthamo namandla angalingani.) Zorvolex 35 mg. i-capsule eluhlaza okwesibhakabhaka nohlaza oluhlaza okwesibhakabhaka ne-IP-204 elifakwe emzimbeni kanye ne-35 mg esikhwameni esimhlophe.
Ukuthatha iZorvolex ngokudla kunganciphisa ukusebenza kahle - akukafundiwe. Futhi, iziguli ezinezifo ezibizwa ngokuthi i-hepatic (isibindi) zingadinga ukulungiswa kwesilinganiso.
Ukusabela Okubi Okuvamile
Ngokususelwa ekuvivinyweni kwemitholampilo, izenzakalo ezivame kakhulu ezihlobene neZorvolex zihlanganisa i-edema, isisulu sokuncibilikisa, ukukhanda ikhanda, isizungu, ukuhlanza, ukuqothulwa, i-pruritis, isifo sohudo, i-flatulence, ubuhlungu emaphethelweni, ubuhlungu besisu, isisusitis, ukwandisa i-ALT (i-alanine aminotransferase), ukwanda kwegazi i-creatinine, i-hypertension, ne-indigestion.
Ukungafani
Iziguli ezingafanele zithathe iZorvolex zihlanganisa: labo abane-hypersensitivity eyaziwayo e-diclofenac; iziguli ezine-asthma, imihlathi, noma yimuphi umphumela wokuphuza emva kokuthatha i-aspirin noma i-NSAID; futhi labo ababa nobuhlungu obuhlobene nomthambo we-coronary ngokudlulela ukuhlinzwa kwe-graft.
Ukuxwayiswa nokuqapha
Izixwayiso ezijwayelekile ezihlobene nazo zonke ezinye izinsiza ze-NSAID, ngokuphathelene nengozi eyingozi yemicimbi ye-cardiovascular kanye nezilonda zamathumbu kanye nokuphuma kwamanzi, nayo isebenza kuZorvolex. Ukuqapha kufanele kusetshenziswe uma iziguli ezinomlando odlule wezilonda zamathumbu noma ukuphuma kwegazi zichazwe iZorvolex. Ukuhlolwa kwegazi kwesibindi kufanele kwenziwe njalo ngezikhathi ukuhlola okungavamile. Iziguli ezithatha i-Zorvolex kufanele zihlolwe futhi ngenxa yegazi lokushisa, ukugcinwa kwamanzi abizayo, i-edema, nokusebenza kwezinso . I-Anaphylactoid kanye nokusebenza kakhudlwana kwesikhumba nakho kungenzeka.
I-Zorvolex akufanele ithathwe nge-aspirin ngoba ukwenza kanjalo kuyokwandisa ingozi yokugaya amathumbu.
Ngokufanayo, iZorvolex akufanele ithathwe ngama-anticoagulants ngoba nayo ingandisa ingozi. Uma usuvele uthatha i-ACE inhibitor, i-diuretic, i-lithium, i-cyclosporine, noma i- methotrexate , ukuqapha kufanele kusetshenziswe ngoba ukusebenzisana kwezidakamizwa kungenzeka.
Kwabesifazane abakhulelwe, izifundo zezilwane zembula ukuthi iZorvolex ingabangela ukulimala emntwaneni. Emva kwamasonto angu-30 ukubeletha, isidakamizwa akufanele sithathwe. Ucwaningo luveze nokuthi lo muthi ungatholakala ebisi lomuntu labamama abahlengikazi.
> Imithombo:
> Ukubeka imininingwane. I-Zorvolex. Kushicilelwe ngo-Agasti 2014.
> I-FDA ivumela i-Zorvolex yokwelashwa kwe-Osteoarthritis Pain. HCPLive. Agasti 25, 2014.