I-Pseudomonas Aeruginosa Inzima Kakhulu Kubantu Abano-CF
Abantu abangaba ngu-60% abanesifo se- cystic fibrosis banesifo esingapheli sokuphefumula esibangelwa amagciwane okuthiwa i-Pseudomonas aeruginosa. Lezi zinambuzane zihlala emcimbini obukhulu obanjwe e-airways. Uma i-Pseudomonas aeruginosa ingena emgwaqweni wokuphefumula, kunzima ukuqeda. Ukuhluleka kokuphefumula okubangelwa ukutheleleka kuyimbangela enkulu yokufa kubantu abaningi abaneCF.
Ama-bacterium Pseudomonas aeruginosa ahlala emhlabeni wonke. Lezi zinambuzane zikhona ezindaweni ezinomanzi ezinjengezungeze inhlabathi, izitshalo, izindwangu, imvula kanye nezicathulo zezicathulo ze-tennis. Iningi labantu lihlangana noPseudomonas aeruginosa nsuku zonke ngaphandle kokutheleleka. Kodwa-ke, kubantu abangenakho ukuzivikela noma kubantu abanekhefu esikhunjeni noma emangcwabeni ye-mucus, la mabhaktheriya angabangela ukutheleleka.
Ngaphandle kokutheleleka abantu abane-CF, i-Pseudomonas aeruginosa iyathinta kakhulu izisulu ezishisayo kanye neziguli ezithola i- chemotherapy . Eminyakeni yamuva, isifo se-Pseudomonas aeruginosa ukutheleleka ngenxa yezizathu ngaphandle kweCF sehlile; kanti, isifo sokutheleleka phakathi kwabantu abane-CF asizange sishintshe.
I-Pseudomonas Aeruginosa iphathwe kanjani?
Eminyakeni edlule, ukutheleleka okungapheli kwePseudomonas aeruginosa ukutheleleka kubantu abane-CF kwakucatshangelwa kunalokho akuphumelelanga ngama-antibiotiki omlomo noma kuhlanganiswe ama- antibiotic angenayo .
Ngasekupheleni kweminyaka yama-1990, uhlobo oluthile lwe-antibiotic tobramycin, noma i-TOBI, lakhiwe ngokukhethekile ekwelapheni izifo ezingapheliyo zokuphefumula eziphuthumayo ze-Pseudomonas aeruginosa. I-TOBI manje iyindlela yokwelashwa ejwayelekile yalokhu ukutheleleka futhi imithi ejwayelekile echazwe kubantu abane-cystic fibrosis.
Kuyini i-TOBI?
I-TOBI yakhiwe i-tobramycin. I-Tobramycin iyi-anti-amicrobial aminoglycoside esetshenziswa ukuphatha ukutheleleka kwe-Pseudomonas aeruginosa. Le antibiotic isebenza ngokuhambisa nge-protein yamaprotheni synthesis. Ngokuhambisa nge-proseine synthesis ye-Pseudomonas aeruginosa, i-TOBI iyaphazamisa ulwelwesi lwesibindi futhi imvulophu ibangela ukufa kwe-cell.
Kuyini i-TOBI Podhaler?
I-TOBI yayisetshenziswa ekuqaleni isebenzisa i- nebulizer . I-nebulizer umshini okhiqiza inkungu enhle yokuphuza. Ngo-2013, i-FDA ivume i-TOBI Podhaler, okuyinto eyomile i-powder inhaler egcwele i-tobramycin eyomile. Le mithi entsha yenza kube lula isiguli ukuthatha i-tobramycin
Ingabe i-TOBI Yomuntu Wonke?
Ngeshwa, i-TOBI akuyona wonke umuntu. Abantu abanezinkinga zokuzwa, izinkinga zezinso, nezinkinga ze-neuromuscular kufanele zibekwe i-TOBI ngokucophelela. Ngokuqondile, ama-aminoglycosides ayaziwa ngokudlela ngokuzwa, izinso kanye nokwandisa izifo ze-neuromuscular ezifana ne-myasthenia gravis. Ukwengeza, abantu abane-hypersensitive ("allergenic") kuya kuma-aminoglycosides akufanele bathathe i-TOBI. Okokugcina, i-tobramycin, eyisithako esisebenzayo ku-TOBI, i-teratogen futhi ingabangela ukulimala ebantwaneni kwabesifazane abakhulelwe.
Umthombo:
Smith, AL "Ukwelashwa kwama-antibiotic okufakwe ngaphakathi: Yiziphi izidakamizwa? Yisiphi Isimo? Iyiphi Regimen? Ikuphi ukubunjwa ?. " Journal of Cystic Fibrosis . 2002 1: S189-S193. 22 Juni 2008.
I-Ramphal R. Izifo Ngenxa ye-Pseudomonas Species and Related Organisms. Ku: Kasper D, Fauci A, Hauser S, Longo D, Jameson J, Loscalzo J. eds. I-Harrison's Principals of Internal Medicine, 19e . ENew York, NY: McGraw-Hill; 2015.