Nge-CFRD i-Pancreas Quits Ukusebenza Ngokufanele
Isifo sikashukela siyinkimbinkimbi evamile eqhubeka ngokuhamba kwesikhathi kubantu abaningi abane- cystic fibrosis (CF). Eqinisweni, iningi labantu abadala abaphila neCF banesifo sikashukela noma ukungabekezelelani kwe-glucose . I-diabetes ehlobene ne-cystic fibrosis (CFRD) iyinhlobo ehlukile yesifo sikashukela esingaba nabantu abano-cystic fibrosis kuphela. I-CFRD iyafana, kodwa ayifani nhlobo, isifo sikashukela kubantu abangenayo i-cystic fibrosis.
Ngenxa yalokho, ukwelashwa kwe-CFRD akufani nokuphathwa kwezinye izinhlobo zesifo sikashukela.
Sibutsetelo sesifo sikashukela
Ngokuvamile, uhlelo lokugaya luguqula okunye kokudla esikudla kulo ushukela. Ushukela, owaziwa ngokuthi i-glucose, ungena egazini. Amazinga aphezulu e-glucose egazini adala ama-pancreas ukufihla i-hormone ebizwa ngokuthi i- insulin , eyasiza ukuthwala i-glucose egazini ukuya emangqamuzaneni omzimba. Kubantu abanesifo sikashukela, le nqubo ayisebenzi kahle futhi i-glucose ihlala egazini. Uma ishiywe ingalashwa, isifo sikashukela singabangela ukulimala okungapheli emehlweni, izinso, inhliziyo kanye nesistimu yezinzwa.
Kubantu abangenayo i-cystic fibrosis, kunezinhlobo ezimbili zesifo sikashukela esingapheli:
Thayipha isifo sikashukela soku-1: Lolu hlobo lwesifo sikashukela, esivame ukutholakala ngaso ebuntwaneni, luba khona lapho ama-pancreas engakhiqiza ngokwanele i-insulin, isimo esibizwa ngokuthi i-insulin ukuntuleka. Ngokungafani nesifo sikashukela sohlobo lwesibili, uhlobo lwesifo sikashukela sohlobo 1 yisimo esizimele.
Ngenxa yalezi zimpawu, uhlobo lwesifo sikashukela sohlobo lwe-1 esetshenziswa ngokuthi "i-insulin-dependent" noma "isifo sikashukela sabantu abasencane." Abantu abanesifo sikashukela sohlobo lwe-1 kumele bathathe i-insulin shots nsuku zonke zempilo yabo noma bangakwazi ukuthuthukisa isimo esisongela ukuphila okuthiwa i- ketoacidosis .
Uhlobo lwesifo sikashukela sesi-2 : Lolu hlobo lwesifo sikashukela, oluvame ukutholakala ukuthi lukhulile, luyenzeka uma ama-pancreas eveza insulini eyanele, kodwa umzimba awuphenduli kahle kwi-insulin, isimo esaziwa ngokuthi ukumelana nesisulini.
Ngenxa yalezi zimpawu, uhlobo lwesifo sikashukela sohlobo luka-2 esetshenziswa ngokuthi "uncike ekungenasinsulini" noma "isifo sikashukela sabantu abadala." Ekuqaleni, abantu abanesifo sikashukela ka-2 ngokuvamile abadingi ukuthatha i-insulin shots. Esikhundleni salokho, bathatha amaphilisi azisiza imizimba yabo isebenzise i-insulin ekhona kakade. Kodwa-ke, abantu abahlala isikhathi eside ngokwanele ngohlobo lwe-2 lwesifo sikashukela ekugcineni badinga ukuthatha i-insulin shots.
Indlela i-CRFD ehlukile ngayo
Isifo sikashukela kubantu abane-cystic fibrosis sihlanganisa izici zombili zohlobo lwe-1 nohlobo lwesifo sikashukela sesi-2. Ukwakhiwa kweminyango eminyene kuma-pancreas ekugcineni kubonakalisa amangqamuzana akhiqiza ama-hormone, okwenza ukuba khona kwe-insulin kungabikho. Lokhu kufana nesifo sikashukela sohlobo lwe-type 1, kodwa akuyona into efanayo ngoba ayiqali ebuntwaneni, kodwa esekhulile, futhi kubangelwa ukulimala kwamaphancasi asetshenziselwa ukukhiqiza i-insulin evamile.
Ngaphandle kokuntuleka kwe-insulin, abantu abane-cystic fibrosis ngokuvamile bavame ukumelana nokukhishwa kwe-insulin ngenxa yalokhu okulandelayo:
- izifo ezingapheli;
- amazinga aphezulu e-cortisol, i-hormone eyenziwa ngumzimba ekuphenduleni ukucindezeleka;
- ukuvezwa njalo kwe- corticosteroids , okuyinto izidakamizwa ezilwa nokuvuvukala ngezinye izikhathi ezisetshenziswa ekwelapheni izimo zamaphaphu ezilingisa isenzo se-cortisol ;.
Izimpawu
Izimpawu zeCFRD zifana nezimpawu zezinye izinhlobo zesifo sikashukela:
- ukoma ngokweqile
- ukuvuthwa njalo
- ukukhathala ngokweqile
- ukulahlekelwa kwesisindo esingachaziwe
Inkinga ukuthi zonke lezi zimpawu ngokuvamile zivela kubantu abane-cystic fibrosis, noma ngabe baneCFRD noma cha. Lokhu kudlula kwenza ukutholakala kokuqala kwe-CFRD kunzima.
Ukuxilongwa
Ngenxa yokuthi izimpawu ze-CRFD angeke ziphawulwe ezinyangeni zokuqala zalesi sifo, i-Cystic Fibrosis Foundation incoma ukuhlolwa kwesifo sikashukela ngokujwayelekile okungenani kanye ngonyaka ukuze bonke abagulayo baneminyaka engu-14 nangaphezulu. I-CFRD itholakala ngokuhlolwa kwegazi okubona amazinga we-glucose egazini.
Ukwelapha
I-CFRD ivame ukuphathwa ngokuhlanganiswa kwe-insulini, ukuzivocavoca nokudla. Ukudla kubantu abane-CFRD kuhlukile ekudleni okukhawulelwe khalori ngokuvamile okushiwo abantu abanezinye izinhlobo zesifo sikashukela. Naphezu kwesifo sikashukela, abantu abane-CF kumele balondoloze i-high-calorie, ukudla okunamafutha aphezulu futhi bahlaziye ngokulungisa ama-insulin. Uma une-CFRD, kuzodingeka usebenze eduze nodokotela wakho kanye nondlovu yokudla ukuze uthuthukise uhlelo lwezokwelapha olusebenza kahle kuwe.
Umthombo:
Hardin, D., et al. 2002. "Ukuphatha i-Cystic Fibrosis-Related Related Diabetes (CFRD)". I-3rd Edition. I-Cystic Fibrosis Foundation. 04 Okthoba 2008