Ukuncipha okuncane ku-TSH: Kungakuthinta Ubukhulu Bakho?

Ucwaningo olwenziwe ngo-May 2005 lwe- Journal of Clinical Endocrinology ne-Metabolism luye lwafakazela ukungavumelani okuphikisanayo emhlabeni we-endocrinology mayelana nokuthi noma ngabe i-hypothyroidism encane ingabangela yini noma ifake iqhaza ekunciphiseni isisindo.

Esicwaningweni, esabheka izihloko ezingaphezu kuka-4600 zocwaningo, abacwaningi bahlola ukuxhuma phakathi kwamazinga wegciwane (kulinganiswa nge- hormone ye -roid stimulating - amazinga e-TSH ) ne-Body Mass Index (BMI) - isibalo esibheka ukuphakama komuntu , kuqhathaniswa nesisindo, futhi uhlukanisa abantu ngezigaba ezahlukene zesisindo, kuhlanganise nesisindo esiphansi, isisindo esivamile, ukukhululeka ngokweqile, nokugqwala.

Lokho abacwaningi abakuthola kwakuhlanganisa ubudlelwane obuhle phakathi kwe-BMI ne-TSH. Lokhu kusho ukuthi i-BMI ikhuphukile njenge-TSH rose, ibonisa ukuxhumana okuqondile phakathi kwamazinga aphezulu we-TSH nesisindo somzimba. Kwakukhona nobudlelwane obubi phakathi kwe-BMI ne- Free T4 , okusho ukuthi njenge-Free T4 (isilinganiso se-circulating isitoreji se-hormone ye-thyroxine egazini), i-BMI yehla.

Ngisho phakathi kwabantu ababenamazinga e-TSH awela ngaphansi kwalokho okuthiwa "ibanga lokubhekisela" - noma "uhla olujwayelekile" - labo amazinga abo awela ekugcineni okuphezulu kwereferensi ejwayelekile yokuhlola yesifundo se-TSH - kulokhu i-TSH ye-4.5 - isilinganiselwa amapremu angaba ngu-12 ngaphezu kwalabo ababephethe i-TSH ekupheleni okuphansi kwereferensi yokubhekisela, nge-TSH ephakathi yama-0.28.

Ngokuvamile, abacwaningi baphetha ngokuthi umsebenzi wegciwane - ngisho nalapho amazinga e-TSH ewela ebangeni lokubhekisela - yinto esiza ukunquma isisindo somzimba, futhi ngisho namazinga e-TSH aphakanyisiwe ahambisana nokwanda kokutholakala ngokweqile.

Ngokuthakazelisayo, umsebenzi we-thyroid unomthelela ofanayo ku-BMI njengomsebenzi ongokomzimba!

Abacwaningi bathole nokuthi ngisho nokuhluka okuncane emsebenzini we -roid - ngaphakathi kwebala lokubhekisela ye-Free T4 - kungabangela ukulawulwa kwesisindo somzimba kubantu. Kucatshangwa ukuthi i-hormone ye-thyroid ejikelezayo ingathinta umzimba "wezindleko zokulala amandla" zomzimba. Ngokusho kwabacwaningi,

"Emphakathini lapho umsebenzi wokuziphilisa wehle kancane kancane, ngisho negalelo elincane kakhulu ekusetshenzisweni kwamandla okwenziwe nge-hormone yegciwane kungakwanela ukufeza ukwanda kwe-BMI."

Abacwaningi baphetha ngokuthi:

"... siphakamisa ukuthi ukungezwani komsebenzi we -roid ngaphakathi kwalokho okubhekwa njengesizinda esivamile kuhlotshaniswa nokungafani ku-BMI, okubangelwa ukuguqulwa okuncane kokusetshenziswa kwamandla kagesi. Lokhu kubonakala kakhulu uma kune-hypo or hyperthyroidism emnene. Ukungafani nokusebenza okunjalo kwe -roid kuphezulu futhi kungathonywa izimo zemvelo. Njengoba izinto ezincane ezingavamile emsebenzini we -roid zivamile, umsebenzi we-thyroid ungabangela kakhulu ukusabalala kokukhuluphala kwabantu. "

Ucwaningo luka-2010

Olunye ucwaningo olushicilelwe kuyi-Journal of Clinical Endocrinology kanye neMetabolism luqinisekisile le miphumela.

UBernadette Biondi we- Thyroid ne-Obesity: Ubuhlobo Obuthandekayo, uthi:

"... i-subclinical kanye ne-overt hypothyroidism ehambisana ne-BMI ephezulu kanye nokukhula okuphakeme kokukhuluphala kokubili kokubhema nabangaboni. Kuye kwaphawula ukuthi ukuhluka okuncane ku-TSH ye-serum kubangelwa izinguquko ezincane kumthamo we-T-4 ngesikhathi sokuguqula ukwelashwa kuhlobene ukuguqula amandla okuphumula kwamandla ezigulini ze-hypothyroid. Lezi zifundo zisekela ubufakazi bokutholwa komzimba ukuthi ukungasebenzi kahle kwe-thyroid kuhlotshaniswa nezinguquko ezibalulekile esisiswini somzimba futhi kungenzeka ukuthi ubonisa isisindo esingozini yokukhuluphala ngokweqile nokukhuluphala. "
... Kubalulekile ukuqaphela ukuthi ukukhula okwedlulele kokukhuluphala emhlabeni jikelele kungase kuqhubekele phambili ukuphazamisa incazelo yezinga elijwayelekile le-TSH kwizifundo zabantu. Ucwaningo olwengeziwe luyadingeka ukuze kunqume ukuthi i-hormone ye-hormone encane ibe yindlala kanti ukwanda kwe-TSH okwenyukayo, okungukuthi emkhawulweni ophezulu we-reference reference, kubandakanyeka ekuthuthukiseni ukukhuluphala. Ngaphezu kwalokho, kudingekile ukuthi kudingeke ukuthi kusetshenzwe izifundo ezingasetshenziswa ukuze kutholakale izinga eliphakeme lamazinga aphakeme e-leptin ekukhuleni okwenyukayo ekwenzeni i-autoimmunity, okuyinto ehlanganisa ingozi enkulu yokuthuthukisa i-subclinical or overt hypothyroidism.

Ukukhuluphala ngokweqile nesifo se-thyroid yizifo ezivamile, futhi ngenxa yalokho abahlengikazi kufanele baqaphele ikakhulukazi ukukhubazeka kwegciwane kumagciwane amaningi. "

ULWAZI OLWENGEZIWE

Nazi izinsiza ezengeziwe mayelana nokuzuza kwesisindo, ukungakwazi ukulahlekelwa isisindo, nokuxhumanisa nomsebenzi we -roid:

Umthombo: Knudsen N, et. al. Umehluko omncane emsebenzini we-thyroid ungabalulekile kwi-Body Mass Index kanye nokutholakala kokukhuluphala kwabantu. " J Clin Endocrinol Metab 2005 Meyi 3