Uma uthatha umjovo wamasonto onke we-interferon, unomvuzo ngenxa yesazi samakhemikhali. Lokhu kungenxa yokuthi ngaphandle kwemakhemikhali we-pegylation kuzodingeka ujobe i-interferon izikhathi ezintathu ngesonto. Ngamafuphi, i-pegylation yenza kube lula ukuphuza imithi yakho futhi empeleni yenza kube ngcono.
Sibutsetelo
I-interferon ye-Pegylated, evame ukubizwa ngokuthi i-peginterferon, ifomu eliguquguqukayo ngokwemvelo le-interferon ejwayelekile eliphatha i- hepatitis C futhi engavamile ukushisa kwesibindi B.
Umehluko phakathi kwe-interferon ne-peginterferon yi-PEG, emele i-molecule ebizwa nge-polyethylene glycol. I-PEG ayenzi lutho ukulwa negciwane. Kodwa ngokuyifaka kwi-interferon (elwa negciwane), i-interferon izohlala emzimbeni (ikakhulukazi igazi) isikhathi eside kakhulu.
Le nqubo ihlomula iziguli ze-hepatitis ezithatha i-interferon ngoba kunokuba zidinga ukujova i-interferon izikhathi ezintathu ngesonto, kuyadingeka umjovo owodwa wamasonto onke. Ngaphezu kwalokho, kuveza izinga eliphezulu lempendulo ye-virologic .
Kunezinguqulo ezimbili ze-peginterferon, ezithengiswa njengePergasys (eyaziwa nangokuthi peginterferon alfa-2a) no- PegIntron (owaziwa nangokuthi peginterferon alfa-2b). Bobabili banezenzo ezifanayo ze-pharmacokinetic, ngezingxabano ezincane phakathi kwalaba ababili.
Ukusebenza
Ngaphambi kokwethulwa kwama-anti-antibodies (DAAs) ngokuqondile-ngo-2013-okubandakanya izidakamizwa zeSovaldi , Harvoni , Daklinza neVikira Phak , phakathi kwabanye-indlela ephumelela kakhulu yokwelapha i-hepatitis C yayihlanganisa inhlanganisela ye-peginterferon ne- ribavirin .
I-thérapie ezimbili ziyaziwa ukuthi zinezinga eliphakeme lemiphumela yokwelashwa, ezinye zazo zingaba zijulile. Noma kunjalo, ukwelashwa okuhlanganisiwe kwakwazi ukuthola impendulo eqhubekayo ye-virologic (incazelo yemitholampilo yokwelapha) ngamaphesenti angama-50 wamacala.
Namuhla, nge-DAA yeklasi elisha, ukusetshenziswa kwe-peginterferon kwehlile kakhulu, nakuba ngezinye izikhathi kusalokhu kunqunywe ezimweni zezifo zesibindi esiphezulu kanye / noma ezigulini eziye zahluleka ukwelapha ngaphambilini.
Ukuphatha
I-Peginterferon ifakwe kanye kanye ngesonto. I-dose ngqo izohluka ngokuya ngezici eziningana, kufaka phakathi i- genotype yegciwane lakho , uhlobo lwe-peginterferon ozolisebenzisa, futhi izidakamizwa ezihambisana nayo zizophathwa ngokufanayo. Umhlengikazi wakho uzokufundisa indlela yokuphatha kahle umjovo, ngokuvamile ngokuphansi (ngaphansi kwesikhumba). I-Peginterferon kufanele ihlale ishicilelwe njalo, futhi izinaliti akumele ziphinde zisetshenziswe noma zihlanganyele.
Okuqhamuka uma udla imishanguzo
Imiphumela emibi ye-peginterferon izohluka kusuka komuntu kuya komuntu, nabanye abantu abaphetheyo bayobona izenzakalo ezimbi lapho abanye bezwa izimpawu abazibona bengenakuziphendulela. Imiphumela emibi kakhulu ehambisana nokusetshenziswa kwe-peginterferon yilezi:
- Izimpawu ezinjenge-Flu (ikhanda, umkhuhlane, amahlumela, ama-muscle aches)
- Ukungalali
- Ukucindezeleka nokushintsha kwemizwelo kuyashintsha
- Ukuthukuthela
- I-nausea nokuhlanza
- Ukuphuza isikhumba
- Ukukhathala okukhulu
- Ukulahlekelwa kwesifiso
- Ukulahlekelwa kwesisindo
Iziguli ezinokwelashwa ziyokhuluma ngeRuba Rage, isimo esiboniswa ukucasula okujwayelekile kanye nokuphulukiswa komzwelo okuphuthumayo, ngezinye izikhathi. Ngesikhathi leli gama libonisa ukuthi imbangela i-ribavirin, ivame ukuhlotshaniswa ne-peginterferon. Ngezinye izikhathi ama-anti-depressants anqunywe ukuze aphathe lesi simo, ikakhulukazi ezigulini ezinezinkinga ezandulela ukugula ngengqondo.
Izindleko
Indlela ephelele yokwelashwa kwe-peginterferon iyabiza kodwa ngenhlanhla, nge-DAA entsha yeklasi, isikhathi sokwelashwa sisifushane kakhulu kunangaphambili.
I-medicaid, i-Medicare kanye nomshuwalense wangasese uyovame ukumboza izindleko ze-interferon lapho ukwelashwa kwe-hepatitis C kuvunywa. Usizo lwe-co-pay lungasetshenziswa ngumkhiqizi wezidakamizwa iziguli ezifanelekile, kanye nezinhlelo zokusiza isiguli (PAPs) eziguli ezingenayo i-uninsured noma ephansi.
Ukungafani
Abanye abantu abane-hepatitis C akufanele bathathe i-peginterferon. Lezi zihlanganisa nabantu abanezimo ezilandelayo:
- Isibindi esiphezulu, inhliziyo, izinso noma amaphaphu
- Ezinye izifo ezizimele ngokuzenzakalelayo
- Ukucindezeleka okukhulu noma ezinye izimo zengqondo
- Ukukhulelwa
- Ukubeletha
Njalo qiniseka ukuthi udokotela wakho unomlando wakho wezokwelapha ophelele, kufaka phakathi ulwazi mayelana nanoma yikuphi ukutheleleka okungapheli okungenzeka ube nakho (isb., I- HIV , isifo sikashukela) noma yiziphi izinhlelo ozidingayo ukuba ukhulelwe.
Imithombo:
I-Katzung, i-BG. Isisekelo sokuPhepha nokuPhepha kwemithi, 10e. ENew York, McGraw-Hill, 2007.
I-Brenner GM, uStevens, i-CW. Pharmacology, 2e. Philadelphia, Saunders Elsevier, 2006.
I-Genentech. "I-Pegasys: Amaphuzu avelele ekuchazeni ulwazi . "
Merck. "I-PegIntron: Amaphuzu avelele ekuchazeni ulwazi."