Ingabe Wena Noma Umdlavuza Wakho Omthandayo I-Chemotherapy Yehluleka?
Iningi labantu lizwile ngemigomo, "umdlavuza" nethi "chemotherapy". Kodwa ngaphandle kokuthi i- chemotherapy isetshenziselwa ukwelapha umdlavuza, abantu abaningi abajwayele ama-nuances ahlobene ne-chemotherapy, njengokuthi igama elithi "chemorefractory" lisho ukuthini.
Ngamafuphi, "i-chemorefractory" ihlobene nokuphendula kwezidakamizwa zamakhemikhali. Ukuze siqonde kangcono "chemorefractory," ake siqale ngezinto eziyisisekelo zokwelashwa kwamakhemikhali.
I-Chemotherapy Basics
Kunezinhlobo ezingaphezu kwekhulu zezinhlobo ze-chemotherapies ezisetshenziswa odokotela benomdlavuza (okuthiwa i-oncologists). Kuye uhlobo oluthile lwesifo somdlavuza nesigaba somdlavuza, i- oncologist izokhetha eyodwa noma inhlanganisela yemithi yokwelapha i-chemotherapy.
Ukuphatha
I-Chemotherapy inganikezwa ngezindlela eziningi ezahlukene. Ezinye izidakamizwa zingathathwa ngomlomo (isibonelo, njengethebhulethi noma ifomu eliketshezi) kuyilapho ezinye zilawulwa njengemjovo, noma zibe izicubu noma izicubu ezinamafutha.
Amanye ama-chemotherapies anikezwa ku-cerebrospinal fluid ngokusebenzisa umthambo wokugogodla (obizwa nge- intrathecal chemotherapy ), esiswini esiswini nge-catheter, esifubeni ngokusebenzisa ithubhu lesifuba, noma ngisho nangokwezihloko (ngaphezulu kwesikhumba).
Kodwa-ke, iningi lama-chemotherapies linikezwa ngomfutho womuntu, futhi lokhu kubizwa ngokuthi ukumiswa kwamakhemikhali.
Indlela
I-Chemotherapy isebenza ngokubulala amangqamuzana akhula ngokushesha, njengamaseli omdlavuza.
Amanye amangqamuzana avamile, anempilo, futhi akhula ngokushesha, njengamaseli emlonyeni nasesisu, amaseli awenza igazi, namaseli enza izinwele. Yingakho abanye abantu belahlekelwa izinwele zabo lapho bethatha izinhlobo ezithile ze-chemotherapy, ukuthuthukisa izidakamizwa kanye nezilonda zomlomo, zibe yi- anemic, futhi / noma bathuthukise inombolo ephansi yamaseli okulwa nokutheleleka (okubizwa ngokuthi amangqamuzana egazi elimhlophe).
Nakuba i-chemo isebenza ngokubulala amangqamuzana omdlavuza, injongo ingahluka. Ngamanye amazwi, umgomo noma umphumela wokulindeleka we-chemo ohambayo awufani nawo wonke umuntu.
Isibonelo, ngenkathi i-chemotherapy ihlinzekwa ukuphulukisa umdlavuza, ingase isetshenziswe esikhundleni sokunciphisa isisu okwanele ukunciphisa ubuhlungu obuhlobene nomdlavuza (okuthiwa i- palliative chemotherapy ) noma ukunciphisa isisu phambi kokuhlinzwa (okuthiwa ukuguqulwa kwamakhemikhali).
Impendulo
Impendulo, elinganiswa ngezikhathi ezithile (ngokuvamile emva kwemikhakha emibili kuya kweyesithathu ye-chemotherapy), ibhekisela ekusebenzeni kahle kwemithi ye-chemo ekubulaleni amaseli omdlavuza.
Odokotela balinganisa ukuphendula ngezindlela ezahlukene ngokususelwa kulohlobo oluthile lomdlavuza. Isibonelo, udokotela angahle acele ukuhlolwa kwesilinganiso se-CT kanye / noma ukuhlolwa kwegazi ukuze kulinganise umaka we- tumor . Lezi zivivinyo ziphindwa ngezikhathi ezithile, ngakho zingafaniswa.
Impendulo kanye nokuxhumeka kwayo ku "Chemorefractory"
Amagama athi "chemorefractory" noma "umdlavuza we-chemosensitive" achaza ukuphendula komdlavuza izidakamizwa ezilwa nazo.
Uma umdlavuza usabela ekhemotherapy, okusho ukuthi iyancipha noma iphela ngemva kokuba umuntu ethola izidakamizwa ze-chemo, umdlavuza uchazwa ngokuthi "i-chemosensitive."
Ehlangothini lwe-flip, uma umdlavuza "i-chemorefractory," awuyihlehlisi noma uphelele ekuphenduleni izidakamizwa ezilawulwa yi-chemo.
Ngezinye izikhathi umdlavuza ongu-chemorefractory ungachazwa ngokuthi "ukwehluleka komdlavuza we-chemotherapy," noma "ukumelana namakthemikhali."
Kubalulekile ukuphawula ukuthi umdlavuza ungase uphazamise ukwelashwa kwamakhemikhali ngokushesha (njengokuqala kokwelapha) noma kungase kube yinkinga yokuphikisa ngesikhathi sokwelashwa.
Ngamanye amazwi, isisu singase siphendule ekomotherapy bese sithola encane, kuphela ukuyeka ukuphendula futhi ungashintshi usayizi, noma ngisho ukhule.
Ngokuqondile, uma kuchaza impendulo (noma ukungabi nampendulo) ekhemotherapy, i-oncologists isebenzisa la magama:
- Kuye kwashiwo impendulo ephelele lapho yonke umdlavuza iphela.
- Ukusabela okuyingxenye kusho ukuthi umdlavuza usuqalile kodwa awukho ngokuphelele.
- Ukusabela okuzinzile kusho ukuthi umdlavuza awuzange ukhule, kodwa futhi awukakhuli.
- Uma umdlavuza uqhubeka, usukhulile, okusho ukuthi kunomdlavuza okwedlula ukwedlula ngaphambi kokwenza amakhemikhali. Kulokhu, udokotela angase ayeke i-chemotherapy kanye / noma aguquke ekhemotherapy ehlukile.
Okwenza I-Cancer Yakho Ingase Ibe I-Chemorefractory
Kunezizathu eziningi zokuthi kungani umdlavuza ungaba yi-chemorefractory nokuqonda lezi zizathu kuyisihluthulelo sokwenza ngcono imiphumela yokwelashwa. Esinye sezizathu ukuthi amangqamuzana omdlavuza angase aguqule ezakhiweni zabo zokwenza izakhi zofuzo, okwenza ukuba ziphikisana ne-chemotherapy. Enye indlela ekhohlisayo yokuthi amangqamuzana omdlavuza abe yi-chemorefractory ngokususa ngokungahambi kahle isidakamizwa se-chemo ngokushesha nje uma ingena embhedeni.
Ezinye izindlela zifaka:
- Amaseli e-Cancer angase afunde ukuthi angalungisa kanjani izidakamizwa ze-DNA ezibangelwa izidakamizwa ezithile ze-chemo.
- Amaseli e-Cancer angathuthukisa "isikhumba esikhudlwana" ukuze akhulume, okwenza ukuthi izimbungulu zabo zingaphansi kwe-permeable, ngakho-ke i-chemo ayikwazi ukungena.
- Amaseli e-Cancer angase ahlele nendlela yokuvimbela lesi sidakamizwa, ukunikeza ukuthi awusebenzi.
Konke lokhu kusho, kubalulekile ukuqaphela ukuthi uma umdlavuza wakho ungumklafractory, akuyona iphutha lakho-akukho lutho olwenzile noma olungenzi lutho olwenza ukuba umdlavuza ungaphenduli.
Ukunciphisa Amathuba Akhe Emdlavuza Wakho Ukuba U-Chemorefractory
Ukuze unciphise amathuba okuba nomdlavuza we-chemorefractory, i-oncologists inembile ekunikezeni iziguli uhlelo lokuqala lwe-chemotherapy kuqala. Lokhu kungenxa yokuthi uma umdlavuza uba yi-chemorefractory kumuthi oyedwa we-chemo noma iqembu lama-chemo izidakamizwa, kungenzeka ukuthi ukuphikisana nezinye izidakamizwa ze-chemo kuphakeme.
Ngaphezu kwalokho, i-oncologists ivame ukuhlinzeka ngezidakamizwa ze-chemo ukuze ziqede umdlavuza ngaphambi kokuba zingabi namandla-ngamanye amazwi, zisebenzisa izikhali zabo ezinamandla kuqala.
Ngaphezu kokukhetha izidakamizwa ze-chemo ezibonisa izinga eliphezulu lokuphendula ngokusekelwe ocwaningweni, i-oncologist yakho izocabangela ezinye izici lapho ukhetha izidakamizwa zakho ze-chemo, njengempilo yakho yangaphandle ngaphandle komdlavuza wakho, kanye nephrofayili yobuthi ( ohlangothini imiphumela ) ye-chemotherapy.
Izwi elivela
Ngenkathi utshelwe ukuthi unomdlavuza we-chemorefractory ukukhathazeka-okuvelele futhi okucindezelayo, akusho ukuthi akukho okukhethwa kukho okushiwo umdlavuza wakho. Ngezinye izikhathi, kusho ukushintshela uhlobo oluhlukile lwe-chemotherapy noma uhlobo olusha lwezokwelapha ngokuphelele.
Qinisekisa ukuthi abacwaningi basebenza kanzima ukuthola izindlela zokwandisa izinga lokuphendula komdlavuza kanye nokunciphisa ukumelana kwamakhemikhali. Ngaphezu kwalokho, ukwelashwa komdlavuza kuhamba ezindleleni ezintsha, njengoba kuboniswa ukuvela kwama- immunotherapies .
> Imithombo:
> I-American Cancer Society. (2017). I-Chemotherapy.
> Cleveland Clinic Chemocare. (2017). Kuyini i-Chemotherapy?
> Krol M, Pawlowski KM, Majchrzak K, Szyszko K, Motyl T. Kungani i-chemotherapy ingahluleka? I-Pol J Vet Sci. 2010; 13 (2): 399-406.
> National Cancer Institute. Incazelo yomdlavuza ophikisayo.
> Sforza V. Imiphumela yomtholampilo yeziguli ezine-chemorefractory metastatic colorectal umdlavuza ophathwa nge-trifluridine / tipiracil (TAS-102): uhlelo olulodwa lwe-Italian institution of compassion. I-ESMO Vula. 2017; 2 (4): e000229.