UMichael Fox, oneminyaka engu-54, waziwa ngezinto eziningi. Umdlali owenza kahle, unqobe imiklomelo yomsebenzi wakhe "Emakhayeni Omndeni," "Umuzi We-Spin," nethi "Umfazi Omuhle." Kodwa-ke, ukuphumelela okuhle kukaFox - iGrammy, Emmys, kanye ne-Golden Globe Awards eceleni - kungaba umsebenzi wakhe ekuqedeni isifo sikaParkinson. Umlingisi wamisa uMichael J. Fox Foundation for Research of Parkinson's (MJFF) ngonyaka ka-2000, eminyakeni eyisishiyagalolunye ngemuva kokutholakala ukuthi unesimo.
Njengoba ekhuluma ngokutholakala kwakhe nomphakathi ngo-1998, uFox ukhulume ngokusesha uchungechunge lwe-stem futhi uye wasebenza ngokuzikhandla ukuze akhiphe imali yokucwaninga. U-Fox okwamanje ukhonza njengomsunguli wenhlangano futhi uhlala ebhodini labaqondisi.
UMichael J. Fox Foundation for Research of Parkinson's Research
UMichael J. Fox Foundation for Research Parkinson unikezelwe ukuthola ukwelashwa kwesifo sikaParkinson. Kuze kube manje, isisekelo sikhulume ngaphezu kwezigidi ezingu-450 zocwaningo lukaParkinson. I-MJFF iphinde ihlose ukuthuthukisa ukwelashwa okungcono kwezibonakaliso ezibhekiswe ngaphansi kwalesi sifo - njengokuqothulwa kwezinkinga, izinkinga zokugwinya, ukulawula ukucindezeleka nokuncipha kwengqondo - kanye nemiphumela emibi yokulimaza kwemithi yamanje kaParkinson.
Uyini izifo zikaPasinson?
Isifo sika-Parkinson sithinta isistimu ye-nervous central eyenza izimpawu eziqhubekayo, eziyekezelayo ezonakalisa indlela umzimba ohamba ngayo.
Uphawu oluphawulekayo lwesimo luyathuthumela, ikakhulukazi ezandleni. "I-Parkinson's" yisikhathi esiphezulu sokungenani izigaba eziyisithupha ze-disorder, eziningi zazo ezithinta abantu abangaphezu kweminyaka engama-50. Isikhathi esijwayelekile sokuxilongwa sino-62 ubudala. Cishe abantu baseMelika abayizigidi njengamanje bahlala nesifo sikaParkinson.
Abantu abangamaphesenti angama-30 abantu abaneParkinson bafunyanwa ngaphambi kokuba bangama-50 - 20 amaphesenti alaba bantu bathola ngaphambi kweminyaka engama-40. Uma i-Parkinson iqala ngaphambi kweminyaka engama-50, iyaziwa ngokuthi i-Parkinson. UMichael Fox, otholakala ukuthi uneminyaka engu-30 ubudala, usekulesi sigaba.
Abantu abanesifo sikaParkinson banokuntuleka kwamakhemikhali okuthinta ukunyakaza (okuthiwa i-dopamine) ebuchosheni babo. Lokhu kubangelwa ukuguqulwa kwamaseli we-substantia nigra, indawo yobuchopho obukhiqiza i-dopamine. Yeka indlela lezi zinguquko ezenzeka ngayo ezingaziwa. Imikhombandlela ihlanganisa ukuguga okusheshayo, ukutholakala kwezakhi zofuzo, kanye nezimo zemvelo, phakathi kwabanye. Kungenzeka ukuthi isifo sikaPasinson sibangelwa ukuhlanganiswa kwalezi zinto.
Ukuthola Ukwelashwa
Ukunakekelwa kwesifo sikaParkinson sekuye kwaba nemithi engasetshenziswa ibe yi-dopamine ebuchosheni (i-Sinemet), noma ngezidakamizwa ezibonakala zithinta ukusetshenziswa kwe-dopamine ebuchosheni (i-Symmetrel, i-Eldepryl). Ukwelashwa kungase kuhlanganise nama-agonists e-dopamine (i-Parlodel, i-Permax, i-Mirapex, i-Requip), eyenza amangqamuzana obuchopho obuzwe obunama-dopamine.
Izinketho zokwelapha zokuhlinzwa nazo ziyatholakala. Enye yezindlela zokuhlinzwa ezivame kakhulu ukuvuselela ubuchopho (DBS).
I-DBS yasungulwa ngawo-1990 kanti manje iyindlela ejwayelekile yokuphatha lesi simo. Ngenkathi i-DBS ingasiza ekuphatheni izimpawu, ayiphuluki lesi sifo futhi ayivimbeli ituthuko. Izinqubo ze-Thalamotomy kanye ne-pallidotomy, ezibhubhisa "amangqamuzana" obangela izinkinga ebuchosheni besebenzisa i-electrode, nazo ziyatholakala.
Imithombo
UMichael J. Fox Foundation for Research of Parkinson's (2016)
I-Parkinson's Disease Foundation (2016)