Ukuqonda Ukusebenzisana Phakathi kwe-Allegra (Fexofenadine) ne-Fruit Juice
Uma uthatha imithi kadokotela noma ngaphezulu kwe-counter Allegra yemithi, kufanele uqaphele ukuthi le mithi ingasebenzisana namajusi wezithelo ezifana ne-apple juice, ijusi lamagilebhisi noma ijusi le-orange. Eqinisweni, uma uphuza isiphuzo sezithelo noma ngisho ne-punch izithelo ngaphakathi kwehora noma ezimbili kokuthatha imithi yakho, ungase ulahlekelwe ukusebenza komuthi ngokuphelele.
Ake sikhulume ukuthi kungani isiphuzo sezithelo singaba yinkinga nge-Allegra, ukuthi kungani lokhu, nokuthi yini ongayenza ukuze ugweme ukuxhumana uma ujabulela ijusi yezithelo.
Kuyini i-Allegra (Fexofenadine)?
I-Allegra (i-fexofenadine) , i- antihistamine engeyona ehlala phansi etholakala kokubili nge-odokotela kanye ne-over-the-counter (OTC) ngaphandle kwemithi. Kusukela kutholakala ngaphezulu kwe-counter, kanye nokuvunyelwa izingane ezincane (ezincane ezinyangeni eziyisithupha,) i-Allegra cishe izoba yithandwa kakhulu kubantu abanezimpawu zokungezwani .
Ngenxa yalesi sizathu, kubalulekile ukuthi abantu bazi ukuthi ukuthatha i-Allegra kanye nama-juice ahlukahlukene wezithelo, ikakhulukazi i-orange ne-grapefruit ijusi, kunciphisa ukumunwa kwe-Allegra ngamaphesenti angaphezu kwesithathu, ngakho-ke ukwenza imithi ingasebenzi kahle.
Ukuxhumana kwe-Allegra (Fexofenadine) ne-Fruit Juice
I-Allegra ixhomeke kuma-receptor akhethekile emafenjini afaka emathunjini amancane okuthiwa i-organic anion ukuthutha i-polypeptides noma i-OATPs.
Ama-protein ase-OATP asiza amakhemikhali (njengamanye imithi) awela izingxube zezinto eziphilayo ezingenakwenzeka kulezi zidakamizwa.
Amajusi wezithelo, njengejusi lamagilebhisi, ujusi we-orange, kanye nomshukela we-apula aqukethe izinto ezivimbela i-OATPs ngakhoke ukunciphisa ukumuncwa kwe-Allegra emzimbeni. (Enye yalezi zinhlanganisela kucatshangwa ukuthi i-naringin.)
Ngeshwa, alithathi isiphuzo esiningi sezithelo ngoba lokhu kuvinjelwa kwenzeke. Ukusetshenziswa kweziphuzo ezithambile ngezinga elingamaphesenti angu-5 kungabangela ukuvimbela ama-OATPs. Ngokuvamile, ukuthatha i-Allegra ngejusi yezithelo kunganciphisa ukumunca ngamaphesenti angaba ngu-40 noma ngaphezulu, okwenza imithi ingasebenzi kangcono ekukhatheni izimpawu zokungezwani. (Ngeke singene kulokho lapha, kodwa ukwehla ngamaphesenti angama-40 omthamo akusho ukuthi uzothola amaphesenti angu-40 omphumela womuthi. Inani elithile lomuthi liyadingeka nganoma yimuphi umphumela ukuze uqaphele, futhi ukunciphisa amaphesenti angu-40 emthamo kungase kusho ukuthi ngeke uthole usizo oluvela kulolo dose.)
Amakhemikhali ejusi avimbela ukumunwa kwe-Allegra kucatshangwa ukuthi asezingeni eliphakeme emanzini atholakalayo okwezentengiso kanye nalawo ase-calcium aqine. Njengoba amakhemikhali ejusi wezithelo okuvimbela ukumunwa kwe-Allegra ayesezithelo zonke, futhi ama-oranges wonke, ama-grapefruit noma ama-apula kufanele agwenywe ngesikhathi esifanayo lapho i-Allegra ixhunyiwe nayo.
Indlela Yokuthatha i-Allegra Uma Uphuza Ijusi Yezithelo
Kubalulekile kumuntu ukuthatha i-Allegra ukugwema izithelo ezintsha noma izithelo zezithelo amahora angu-1 kuya kwangu-2 ngaphambi nangemva kokuthatha i-Allegra.
Uma kungenjalo, ukuphumelela kwe-Allegra kuzokwehliswa kakhulu, futhi izimpawu zokungezwani komzimba noma imifuba cishe kuyoshiywa ingalawulwa.
Eminye Imishanguzo Yezokwelapha kanye neJaji Lezithelo
Uma ukuthola okulukhuni ukuthatha imithi emibili ngemini futhi ugijime ukudla kwakho kwejusi yezithelo, kunezinye izinketho. Ungase ufise ukushintshela emithonjeni ehlukile yokungezwani komzimba engathinteki ngokudla izithelo noma ijusi lesithelo. Kunezinhlobo zemithi ehlukene etholakalayo yokuthola i- rhinitis ye-allergen , njengoba kuneminye imithi yama-hives (i-urticaria.)
Kulabo abanesifo se-hayfever esilinganiselwe, noma kubantu abane-hive, imithi efana ne- Zyrtec (cetirizine) noma i-Xyzal (levocetirizine) ingahle iphumelele kakhulu kune-Allegra.
Le mithi, kodwa, ingabangela ukugubha kwabanye abantu.
I-Claritin (i-loratadine) enye inketho efana nokuphumelela ku-Allegra. Funda kabanzi mayelana nokwahlukana phakathi kwe-Allegra, i-Zyrtec, no-Claritin .
Eminye Imithi Engayithinteka Ngamajusi Ezithelo
Akukhona kuphela amazinga e-Allegra emzimbeni ongathinteka ngokudla izithelo noma ijusi lesithelo. Izithelo zingase zivimbele ukutholakala kwamathumbu kwamanye ama-antibiotic, imithi ethile yegazi, imithi ethile ye-cholesterol, kanye neminye imithi yempilo efana ne-beta-blockers. Abanye abacwaningi baye baphakamisa ukuthi noma yimiphi imithi kufanele ithathwe ngaphandle kwewindi lehora elilodwa elizungeze ukusetshenziswa kwesithelo noma ijusi lesithelo.
Ngezansi Ngomuthi Wezithelo no-Allegra
Njengoba ukudla izithelo noma ijusi yezithelo kungaphazamisa kakhulu ngokumunwa kwe-Allegra, isikhathi somuthi wakho kufanele sihlelwe okungenani amahora amabili ngaphambi kokuqala noma amahora amabili emva kokuphuza ijusi yezithelo. Uma lokhu kuveza inkinga, kunezinye izifo ezihamba kahle ze-hay kanye nemithi yomhlathi ongasetshenziswa esikhundleni sayo.
Ngokuthakazelisayo, izimpawu eziphathwe yi-Allegra njenge-hay fever kanye nezihlahla zomzimba akuzona ngokuvamile ezisongela ukuphila, nakuba zinganciphisa kakhulu izinga lakho lokuphila. Kunezizathu ezingaphezu kwezimpawu, noma kunjalo, ukunaka ukusebenzisana kwezithelo zezithelo kanye ne-Allegra. Akuwona nje umqondo omuhle ngokwezezimali ukuthenga futhi uthathe isikhathi sokuthatha imithi engeke ifakwe.
Lokhu kusebenzisana kuyisibonelo esihle ukuthi imithi ingase ingangqubuzana kanjani kuphela, kodwa ngokudla ekudleni kwethu. Nganoma imuphi imithi, kubalulekile ukufunda ukuphrinta okuncane futhi ukukhuluma nodokotela wakho kanye nemithi mayelana nanoma yikuphi ukuxhumana okungenzeka. Thatha isikhathi sokufunda kabanzi mayelana nendlela yokunciphisa ingozi yemiphumela emibi nokusebenzisana kwezidakamizwa .
> Imithombo:
> Akamine, Y., Miura, M., Komori, H. et al. Ukuguqulwa kwe-Pharmacokinetics ye-Fexofenadine Enantiomers Ngomuthi owodwa kanye nesikhathi esisodwa we-Grapefruit Juice Ingestion. I-Metabolism ne-Pharmacokinetics . 2015. 30 (5): 352-7.
> Andrade, C. Izithelo Juice, Organic Anion Ezokuthutha Polypeptides, kanye Ukusebenzisana kwezidakamizwa in Psychiatry. Journal of Psychiatry Clinical . 2014. 75 (11): e1323-5.
> Luo, J., Imai, H., Ohyama, T. et al. I-Pharmacokinetic Exposure to Fexofenadine Umqulu-Ngokuzenzeke Kuncishiswe Ezifundweni Ezempilo Ukulandela Ukuphathwa Kwemlomo Ne-Apple Juice. Isayensi yezokwelapha kanye nokuhumusha . 2016. 9 (4): 201-6.
> Won, C., Lan, T., Vandermolen, K. et al. IJuji eliQuqulwa ngamagilebhisi eliguqulwa lihlukanisa amakilasi amabili e-Compound njengoMlamuli Omkhulu we-Grapefruit Juice-Fexofenadine Ukusebenzisana: Njengo-In Vitro-In Vivo "Xhuma.". Journal of Pharmacology . 2013. 53 (9): 982-90.