Njengomuntu ongase azibuze ukuthi wena noma othandekayo une- systemic lupus erythematosus (i-SLE noma i-lupus), kungenzeka ukuthi uthola noma wezwa igama elithi ANA-negative lupus elifakwe kumaforamu noma phakathi kweontanga. Uma kunjalo, ungase uzibuze ukuthi yikuphi, i-ANA-negative lupus. Futhi kungcono, ingabe i-ANA-negative lupus ikhona?
I-ANA-Negative Lupus
Ngokwemibandela elula, i-ANA-negative lupus yisimo lapho umuntu we-ANA - noma i-antinuclear anti- test - ebuyela emuva engalungile, kodwa lowo muntu ubonisa izici ezihambisana nomuntu otholakala ene-lupus.
Isivivinyo se- ANA sisetshenziselwa ukuhlola i-lupus, hhayi ukuyihlola.
Ngokuvamile, uma umuntu evivinya ukuthi uphikisana ne-antinuclear antibody, kusho kuphela ukuthi lowo muntu angaba ne-lupus. Ukuhlolwa okuqhubekayo kuyadingeka ukunquma ukuthi umuntu empeleni une-lupus. Lokho kuhlanganisa ukuhlolwa kukaSm (Smith), uRo / SSA (i-Sjogren's syndrome A), iLa / SSB (i-Sjogren's syndrome B), ne-RNP (ribonucleoprotein) antibodies.
Uma ukuhlolwa kwe-ANA kubuya okungalungile, khona-ke i-lupus ayikwazi ukuba khona, futhi ngokuvamile, akudingeki ukuhlolwa okwengeziwe.
Kodwa ezimweni ezingavamile, ezinye iziguli zibonisa izici ezihambisana ne-lupus, ikakhulukazi lezi ezine, ezihlola ngokungaqondile i-SLE:
- I-anti-double anti-double-stranded anti-DNA antibody
- Anti-Sm (Smith) antibody
- Isifo sesifo sezinso esivelele
- Isifo sesikhumba esiqinisekisiwe
Ngaphezu kwalokho, ukuhlolwa kwe-antibody kanye nezimpawu ziyahambisana. Ama-antibodies kuphela awayitholi lesi sifo. Uma unayo zonke izici ezine ezikhonjisiwe ngenhla, cishe, uzobona ukuthi une-SLE.
Uma kungenjalo bonke abane, kunanoma yisiphi isifo sokuxilonga, kuwukuqhosha . Kucatshangwa ukuthi isiguli sinomphefumulo we-lupus, ngisho noma ukuhlolwa kwe-ANA kubuyela emuva.
Kodwa linda ...
Ingabe i-ANA-Lupus Negative ikhona?
Ukuvumelanisa ngokujwayelekile ukuthi i-ANA-negative lupus iyinto engavamile kakhulu - futhi iningi elidluliselwa iziguli ezine-"lupus-like". Abanye odokotela bangase bakubize ngokuthi " izifo ezixutshwe nezicubu ezixubene ," " izifo ezixhumene nezicubu ezingenalutho ," noma "i-form fruste lupus" - noma "i-lupus efihliwe".
Ngamunye ukhuluma ngokucacile futhi ahlukanise incazelo futhi uchaza izinhlobo ezahlukene zokugula.
Ngamafuphi, umphakathi wezokwelapha awukwazi ukuvuma ukuthi ngabe i-ANA-negative lupus ikhona ngempela njengesimo sezokwelapha. Abaningi bayisebenzisa njengendlela yokuchaza ukugula okulinganisa i-lupus noma okungenzeka kube ne-lupus, kodwa ngeke kutholakale ngokungaqondile ngokuthi i-lupus.
Faka enye indlela, udokotela uMichael D. Lockshin, MD, uyabhala:
Impendulo yombuzo, 'Ingabe i-ANA-negative lupus ikhona?' ngokuyisisekelo 'yebo', enombalwa omkhulu wezinkinobho, ne-ifs, kanye neyiphi. Enye impendulo ukuthi umbuzo awubalulekile kakhulu. Akukaze kubaluleke kakhulu ukusho ngokucacile ukuthi isiguli esinikeziwe senza noma asinayo i-lupus. Okubalulekile ukuhlola izimpawu zamanje, ukufaka izimpawu zibe yinto ejwayelekile ehlanganisa ukuhlolwa kwegazi, ubude bezimpawu, ezinye izifo, kanye nemithi, nokuthuthukisa uhlelo lokwelapha ngokusekelwe kolwazi oluphelele kunokuba kuhlolwe igazi yedwa.
> Imithombo:
> ANA Negative Lupus Isikhungo se-Arthritis sikaJohn Hopkins. Julayi 2008.
> ANA Negative Lupus QJM: I-International Journal of Medicine. Umqulu 97, Inombolo 5 Pp. 303-308.
> Ikhona i-ANA-negative lupus ekhona? Yiziphi ezinye izakhamuzi eziwusizo lapho ucabanga ngalesi sifo, futhi kuthiwani uma zonke zingalungile? Buza uchwepheshe. UMichael D. Lockshin, MD. Julayi 2008.