Isifo Sezimpawu Eziqhekezayo
Izifo ezixubile zezicubu (MCTD) yisifo esizimele ngokwezinye izifo ezithinta izicubu ezintathu-izimpikane ze- lupus erythematosus , i- scleroderma ne-polymyositis.
Isizathu
Isizathu se-MCTD asiyazi. Cishe amaphesenti angu-80 abantu abathintekayo abane-MCTD ngabesifazane. Lesi sifo sithinta abantu abaneminyaka engama-5 kuya kwengu-80 ubudala kanye nokusabalalisa okuphezulu phakathi kwentsha noma abantu abaneminyaka engama-20.
Kungase kube khona izakhi zofuzo kodwa akulona ifa eliqondile.
Izimpawu
Izimpawu zokuqala zezifo ezixubene nezicubu zifana nezibonakaliso ezihlobene nezinye izifo ezixhumene nezicubu futhi zingabandakanya:
- Ukukhathala
- Ubuhlungu besisu noma ubuthakathaka
- Ubuhlungu obuhlangene
- I-low-grade fever
- Isimo sikaRaynaud
Izimpawu ezingavamile ezihambisana ne-MCTD zibandakanya i-polymyositis ejulile (ikakhulukazi ethinta amahlombe nezandla ezingaphezulu), ubuhlungu obukhulu be-arthritis, i-aseptic meningitis, i-myelitis, i-aseptic yeminwe nezinzwane, umkhuhlane omkhulu, ubuhlungu besisu, inzwa ye-nerve trigeminal ebusweni, ubunzima bokugwinya, ukuphefumula nokuphulukana nokuzwa. Amapayipi athathwe ngamaphesenti angaba ngu-75 abantu abane-MCTD. Cishe amaphesenti angu-25 weziguli ezine-MCTD zibandakanyeka kwezinso.
Ukuxilongwa
Ukuthola ukuxilongwa kwezifo ezixubileyo zezifo kungaba nzima kakhulu. Izici zezimo ezintathu-i-lupus erythematosus, i-scleroderma, ne-polymyositis-ngokuvamile ayikwenzeka ngesikhathi esifanayo.
Kunalokho, bavame ukuthuthukisa eyodwa ngemva kwesikhathi esithile.
Kodwa-ke, kunezici ezine ezingasikisela ukuxilongwa kwe-MCTD kunokuba umuntu ahlukane nesifo somzimba:
- Ukugxila okuphezulu kwe-RNP anti-U1 (ribonucleoprotein) egazini
- Ukungabikho kwezimpikiswano ezithile ezivamile ne-systemic lupus erythematosus, njengezinkinga zezinso nezinkinga zesistimu eziphakathi
- I-arthritis ejulile ne-hypertension yamapayipi (engejwayelekile kwi-systic lupus noma i-scleroderma)
- Isenzo sikaRaynaud, kanye nezandla ezivuvukala (ezingajwayelekile ne-systemic lupus)
Ngesikhathi ukutholakala kwe-RNP anti-U1 kuyisici esiyinhloko esibonakalayo esivumela ukuxilongwa kwe-MCTD, ukutholakala kwe-antibody egazini kungaba empeleni kuqala izibonakaliso.
Ukwelapha
Ukwelashwa kwezifo ezixubileyo zezicubu kuhlose ukulawula izimpawu nokulawula imiphumela ebuhlungu yesifo, njengokubandakanyeka komzimba. Isibonelo, umfutho wegazi ophezulu we-pulmonary kufanele uphathwe ngemithi elwa ne-hypertensive. Izimpawu zokuvuvukala zingase zibe zibuhlungu kuze kube nzima, futhi ukwelashwa ngokufanele kuyokhethwa ngokusekelwe ebucayi. Ukuvuvukala okuncane kakhulu, ama-NSAID noma i- corticosteroids ephansi-dose anganikezwa. Ukuzivocavoca okuncane kungadinga i-corticosteroids yezinga eliphezulu. Uma kukhona ukubandakanyeka komzimba, ama-immunosuppressants angabekwa.
I-Outlook
Ngisho nangendlela yokuthola i-diagnostic enembile nokuphathwa ngendlela efanele, kungase kube nzima ukusungula ukubikezela. Ukuthi isiguli senzani kahle kuxhomeke ukuthi yiziphi izitho ezibandakanyekayo, ubukhulu bokuvuvukala, nokuqhubeka kwesifo. Ngokomtholampilo waseCleveland, abantu abangamaphesenti angu-80 basinda okungenani eminyakeni eyishumi ngemuva kokutholakala ukuthi bane-MCTD.
Isibikezelo se-MCTD siba sibi kakhulu kuneziguli ezinezici eziboshwe kwi-scleroderma noma i-polymyositis.
Kubalulekile ukuqaphela ukuthi kungase kube nezinkathi ezandisiwe ezingenasifo, ngisho nangaphandle kokwelashwa kwe-MCTD.
> Imithombo:
> I-Bennett R. Anti-U1 I-RNP Antibodies ku-Mixed Connective Izifo Zesishukela. Kusesikhathini.
> Firestein GS, uKelley WN. I-Kelleys Textbook ye-Rheumatology . Philadelphia, PA: Elsevier / Saunders; 2013.
> Gunnarsson R, Hetlevik SO, uLilleby V, Molberg Ø. Isifo esithinta izicubu. Ukusebenza Okuhle Kakhulu Nokucwaninga I-Rheumatology Clinic . 2016; 30 (1): 95-111. doi: 10.1016 / j.berh.2016.03.002.
> Izifo Ezixhumene Nezingxube Ezixubile. Umtholampilo waseCleveland.