UCTD ihluke kanjani ku-MCTD?
Izifo zesifo sofuba ezingabonakali (UCTD) kanye nezifo ezixubene nezicubu (MCTD) yizimo ezinokunye okufana nezinye izifo zesimiso esizimele noma izifo zesishukela , kodwa kukhona ukuhlukaniswa okubenza bahluke. Esifweni se-systemic autoimmune, umzimba wonke uphethwe futhi amasosha omzimba , evame ukuvikela umzimba ngokuhlasela abahlaseli bangaphandle, ahlasele izicubu zomzimba.
Esifweni esithinta izicubu, njengoba igama lisikisela, izicubu ezixhumeneyo zihlaselwa futhi zithintekile. Izishukela ezixhumeneyo zisekela futhi zixhuma izingxenye ezihlukahlukene zomzimba futhi zihlanganisa isikhumba, i-cartilage nezinye izicubu.
Izifo ezixubileyo zezicubu yisifo esizimele ngokuzihlanganisa nezinye izifo ezintathu ezixhumene nezifo - i- systemic lupus erythematosus , i- scleroderma , ne-polymyositis. Ngezinye izikhathi ibizwa ngokuthi i-overlap syndrome. Ngokuphambene nalokho, izicubu ezingaxhunywanga izifo Izifo azikho okwanele izici noma izinqubo okumele zihlukaniswe njengenye yezifo ezizimele noma izifo ezixhumene nezicubu.
Izici zezifo ezixhumene nezidakamizwa ezingaxhunywanga
Iziguli ezinezinambuzane ezixhumene nezifo ezingenalutho ezingenayo impawu (isb., Ubuhlungu obuhlangene), imiphumela ye-lab yokuhlolwa (isib. I- ANA enhle), noma ezinye izici zesifo esizimele, kodwa azigculisi imigomo yokuhlukanisa izifo ezithile ezithinta izicubu ezifana ne-lupus , isifo samathambo , isifo se- Sjogren's , scleroderma, noma abanye.
Uma kunezici ezinganele ukuthi zihlukaniswe njengezinye izifo zesishukela, lesi simo sichazwa ngokuthi "ukungenzi lutho". Isiqalo sezifo ezixhumene nezifo ezingenakudlalwa kuqala saqala ukusebenza ngawo-1980. Ngokuyinhloko, yayisetshenziswa ezigulini ezazicatshangwa ukuthi zisezinkathini zokuqala zezifo ezixhumene nezicubu.
I-lupent lupus kanye ne-lupus erythematosus engaphelele kwakungamanye amagama asetshenziselwa ukuchaza leli qembu leziguli.
Kucatshangwa ukuthi iziguli ezingama-20% noma ezimbalwa ezinezifo ezixhumene nezifo ezingenazo izifo ziqhubekela phambili ekuxilongweni okucacile kwesifo sofuba. Cishe ingxenye yesithathu ingena ekuxoxweni, futhi abanye bahlale bezinkinga ezimbi ezingekho emthethweni.
Izimpawu zobunzima zezifo ezingasebenzi ezingenayo imfucuza zibandakanya i-arthritis, i-arthralgia, isenzo sikaRaynaud , i-leukopenia (isibalo esincane segazi eliphansi), imfucuza, i-alopecia, izilonda zomlomo, amehlo anomile, umlomo omile, umkhuhlane ophansi, nokuvezwa kwezithombe. Ngokujwayelekile, akukho ukubandakanyeka kwegazi noma kwezinso, noma ukubandakanyeka kwesibindi, amaphaphu, noma ubuchopho. Iningi leziguli ezinezifo ezifakwe engxenyeni engafanele, mhlawumbe engu-80%, zinephrofayili elula ye-autoantibody, ngokuvamile i-anti-Ro noma i-antiantibodies ephikisana no-RNP.
Ukuqaphela nokuphatha i-UCTD
Njengengxenye yenqubo yokuxilonga yezifo ezixhumene nezidakamizwa, umlando ophelele wezokwelapha, ukuhlolwa ngokomzimba, nokuhlolwa kwelabhorethri kuyadingeka ukuze kungabikho ukutholakala kwezinye izifo ze-rheumatic. Ngokuphathelene nokwelashwa kwezifo ezingenalutho ezingasebenzi, akuzange kube khona izifundo zesayensi ezisemthethweni zokwelashwa okuqondene nezifo ezingaxhunywanga izifo ezixubile.
Ukukhethwa ukwelashwa ngokuvamile kuxhomeke ezimpawu ezinikezwe kanye nempumelelo yangaphambilini yodokotela ekudaleni ukwelashwa okukhethekile ngezifo ze-rheumatic.
Ngokujwayelekile, ukwelashwa kwe-UCTD kunezinhlanganisela ezithile ze- analgesics nama- NSAID ukuphatha ubuhlungu, i-corticosteroids yama-topical yesikhumba kanye nezicubu zamangcwaba , ne- Plaquenil (i-hydroxychloroquine) njengesidakamizwa sokuguqula isifo sokulwa nesifo (DMARD). Uma impendulo enganele, i- prednisone yomlomo ophansi ngomlomo ingangeniswa isikhathi esifushane. Amazinga aphezulu ama-corticosteroids, izidakamizwa ze-cytotoxic (isib. I-Cytoxan), noma ezinye i-DMARDS (njenge-Imuran) azivame ukusetshenziswa.
I-Methotrexate ingaba yindlela yokwelashwa okunzima ukuphathwa kwezifo ezingenalutho.
Okubalulekile
Isibikezelo sezifo ezixhumene nezidakamizwa ezingenakubalwa kuyamangalisa okuhle. Kukhona ingozi encane yokuqhubekela phambili ekuhloleni kahle kwezifo zesishukela, ikakhulukazi phakathi kweziguli ezithintekayo izifo ezixhumene nezifo ezingasebenzi ezingaphendulwanga iminyaka emihlanu noma ngaphezulu. Amacala amaningi ahlala emnene futhi izimpawu zitholwa ngaphandle kwesidingo sokusebenza okungenamandla okuzivivinya umzimba.
Imithombo:
Izifo Ezixhumene Nezifo Ezixhunyanisiwe (UCTD). UMosca M. et al. Ukubuyekeza okuzenzakalelayo. 2006 Nov; 6 (1) 1-4. http://www.ncbi.nlm.nih.gov/pubmed/17110308
Izifo Ezixhumene Nezifo Ezixhumeneyo - Ukubuka Okujulile Kwangaphakathi. UJessica R. Berman, MD. Isibhedlela Sokuhlinzwa Okukhethekile. 11/10/2009. https://www.hss.edu/conditions_undifferentiated-connective-tissue-disease-overview.asp