Kuye kwacatshangwa ukuthi izidakamizwa ze- Accutane (isotretinoin) zingase zixhunywe ekuthuthukiseni isifo sofuba esiswini (IBD) . Ulwazi lwesiguli se-Accutane luyavuma ukuxhumana phakathi kwesidakamizwa ne-IBD. Kuye kwafakwa amacala amaningi ngokumelene neRoche Holding AG, abenzi be-Accutane, okunye okwaholela ekugwetshweni ngokumelene nenkampani yezokwelapha.
Ezinye zalezi zigwegwe kamuva zaguqulwa , kanti ezinye zisalindelwa. U-Accutane wasuswa ngokuzithandela emakethe ngoJuni 2009, kodwa izinguqulo ezivamile zisekhona.
Ucwaningo Lithini?
Ucwaningo olulodwa lwaphetha ngokuthi lesi sidakamizwa singase sibe yi- IBD yokuqala kwezinye iziguli. Ukubuyekezwa kuka-2009 kwezincwadi ezitholwe ukuthi kwakungekho ubufakazi obanele bokufakazela noma ukuphikisa ukuxhumana phakathi kwezidakamizwa nokuthuthukiswa kwe-IBD. Ucwaningo lwe-case-control lwango-2010 lubonise ukuthi i-Accutane ihlotshaniswa nobungozi obuncane kakhulu bokuthuthukisa i-ulcerative colitis, kepha akukho ukuxhumana nesifo sikaCrohn. Abalobi balolu cwaningo bakhombisa ukuthi ingozi ye-ulcerative colitis ingase ihlotshaniswe nezindleko eziphakeme ze-Accutane. Ucwaningo lwesithathu luphetha ngokuthi abantu abathatha i-Accutane babengekho amathuba okuthuthukisa i-IBD kunoma ubani omunye, kodwa bavuma ukuthi kunemibiko ye-anecdotal ye-IBD-Accutane uxhumano.
Ama-antibiotics ne-IBD
Kodwa olunye ucwaningo lwango-2010 lubonise ukuthi amanye ama-antibiotic amaningi avame ukushiwo ekwelapheni induna enamandla angase ahlotshaniswe nokuthuthukiswa kwe-IBD . Lezi zinambuzane zivame ukuthathwa isikhathi eside, futhi uma zihluleka ukulawula i-acne, i-Accutane ivame ukukhetha ukwelashwa okulandelayo.
Abalobi besifundo bacacisa ukuthi ukusetshenziswa kwe-antibiotic yesikhathi eside kungase kube yi-IBD trigger futhi ukuthi namanje akusobala ukuthi i-Accutane ingajoyina kanjani ekuxubeni.
Ukuxhuma Phakathi Kwe-Acne ne-IBD
Ukubuyekezwa okwenziwe ngo-2011 kucatshangelwe ukuthi kungaba khona ngempela ukuxhumana phakathi kwe-acne ne-IBD. I-acne ejulile ne-IBD yizimo zombili zokuvuvukala, futhi bobabili bavame ukutholakala ezintwaneni ezincane kanye nabantu abadala. Abalobi baqhubeka beveza ukuthi uma umuntu osemusha engaphansi kokunakekela odokotela njalo, ezinye izimo (njenge-IBD) zingabonakala.
Okubalulekile
Zonke lezi zifundo zibonisa ukuthi kukhona ubufakazi bokusekela kokubili isimangalo ukuthi i-Accutane ibangele IBD nesimangalo sokuthi i-Accutane ayibangeli IBD. Lokhu akusizo usizo kunoma ubani ocubungula ukwelashwa kwe-Accutane, noma kulabo asebenzise i-Accutane esikhathini esidlule, kodwa kaningi indlela yocwaningo lwezokwelapha olusebenza ngayo. Kungathatha iminyaka ukuvumelanisa ngokujwayelekile ukuvela ezincwadini zezokwelapha. Uhlelo lwenkantolo luyindaba ehlukile, futhi izinkantolo zingabangela isahlulelo nganoma yiluphi uhlangothi lwendaba.
Ngemva kokubukeza lobu bufakazi, omunye angase azibuze ukuthi ucwaningo luya endleleni engalungile: ingabe kukhona ubuhlobo phakathi kwe-IBD ne-acne?
Mhlawumbe kwezinye zezimo, i-IBD yayivele ikhona, kodwa ayitholakalanga kuze kube yilapho iselashwa nge-Accutane. Okwamanje akukho bufakazi obukhona noma ngokumelene nalesi sizathu. Noma kunjalo, kufanele kuqashelwe ukuthi i-steroids (ikakhulukazi i- prednisone ), enye yezokwelapha ezivame kakhulu ze-IBD, ingabangela i-acne eqinile .
Amaphuzu Okucabangela Ngayo Ama-Acne Treatment
Uma ucabangela ukusebenzisa i-Accutane , noma uma usebenzise lesi sidakamizwa esikhathini esidlule futhi ukhathazekile nge-IBD, kufanele uxoxe ngengozi yakho ne-dermatologist yakho. Khumbula ukuthi uma kukhona ingozi yokuthuthukisa i-IBD ngemuva kokuthatha i-Accutane, kusengumcimbi ongavamile kakhulu.
Olunye ucwaningo lokulawulwa kwezimo olwenziwe ngo-2011 lubonisa ukuthi labo abacabangela ukuthatha i-Accutane baqaphele ingozi encane yokuthuthukisa i-ulcerative colitis.
Kubantu abavele benayo i-IBD, ikakhulukazi i-ulcerative colitis, futhi ngubani ofuna ukwelashwa nge- acne eqinile , ukwelashwa kokuqala kwe-line ngokuvamile kuvamise ama-topical agents. Uma ukwelashwa kwama-topical kungasebenzi, ama-antibiotic kanye nama- antimicrobial angasetshenziswa.
Imithombo:
I-Accutane Information Patient Information. Roche. 2 Septemba 2010.
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