Ukuhlolwa kwe-LDH kungasiza udokotela wakho ukuba anqume ukuthi ngabe umdlavuza wakho wesikhumba usakaze yini
I-LDH ukuhlolwa kwegazi okulinganisa inani lactate dehydrogenase (LDH), i-enzyme, egazini lakho. Ngokomzimba, i-LDH isebenza ukuguqula i-pyruvate ne-lactate emzimbeni wakho. Ungase ujwayelane ne-lactate, njengoba yilokho okubuthela emzimbeni wakho emva kokusebenza okunzima futhi kukwenze uzizwe ukhululekile.
Sibutsetelo
Ngokuvamile, i-LDH ilinganiswa ukuhlola ukulimala kwezicubu ezindaweni ezifana nenhliziyo yakho, isibindi, izinso, isisipha samathambo, ubuchopho, namapayipi - konke okukuthi, uma kulimele, kukwandisa izinga le-LDH egazini lakho.
Uma une- melanoma , udokotela wakho angasebenzisa lesi sivivinyo ukuze asize ukuthi unomdlavuza wakho ususelwe noma usakazeka ezithombeni ezingaphezu kwesikhumba sakho namagciwane . Izindawo ezivame kakhulu zomdlavuza ozoqhubeka zivame isibindi namaphaphu. Yize i-LDH ingeyona into ecacile ye-melanoma, kungaba umvivinyo owusizo wokuxilonga noma ukuqapha ukwelashwa kwesikhumba ngemuva kokuhlinzwa. Uhlelo lwesiteji se-melanoma lusebenzisa imiphumela yanoma yikuphi ukuhlolwa kwe-LDH ukuhlukanisa iziguli ezinezifo ze-stage IV.
Ukuhlolwa Kwenziwe kanjani
Ukuze unqume amazinga akho e-LDH, umhlinzeki wakho wezempilo uyokhipha igazi emthonjeni wakho noma esithendeni sakho, ngomunwe, onozinyo, noma endlebeni. I-laboratory isheshe ifinyelele igazi ukuze ihlukanise i-serum, ingxenye yetshezi yegazi lakho, kusuka kumaseli egazi. Ukuhlolwa kwe-LDH kwenziwa kwi-serum yakho yegazi.
Ngaphambi kokudonswa kwegazi, udokotela wakho angakucela ukuba uyeke ukuthatha izidakamizwa ezithile ezaziwayo ukuthi zithinte i-LDH.
Izidakamizwa ezingakhuphula i-LDH zihlanganisa utshwala, i-anesthetics, i-aspirin, i-clofibrate, i-fluorides, i-mithramycin, i-narcotics, ne-procainamide. I-ascorbic acid, noma i-vitamin C njengoba eyaziwa kakhulu, inganciphisa i-LDH yakho.
Yiziphi Imiphumela Zokuhlola Okushiwo
Amanani avamile angase ahluke kuye ngokuthi uneminyaka yakho, ubulili, kanye nendlela ethile esetshenziselwa laboratory.
Ibanga lokubhekisela elivamile ngokuvamile liyi-105 kuya ku-333 IU / L (amayunithi angamazwe angama-litre ngalinye). I-LDH ingqikithi ivame ukuhlukaniswa ngezigaba ezinhlanu (okubizwa nge-isoenzymes) - LDH-1, LDH-2, LDH-3, LDH-4, ne-LDH-5 - ecacile ezindaweni ezithile zomzimba futhi iboniswa njengamaphesenti yonke.
Izinga le-LDH lingaphakanyiswa ezimweni eziningi, hhayi kuphela i-melanoma ye-metastatic. Amazinga aphezulu kunamajwayelekile angabonisa nokuthi:
- ukushaya
- isifo senhliziyo
- izinhlobo ezahlukene ze-anemia
- umfutho wegazi ophansi
- isifo sesibindi (isibonelo, isifo sofuba)
- ukulimala kwemisipha
- i-dystrophy yemisipha
- i-pancreatitis
Imiphumela ephakeme yamanga ingenzeka uma i-specimen yegazi igcinwa cishe, igcinwe emazingeni okushisa okwedlulele, noma uma isampula kwakunzima ukuyiqoqa.
Yimiphi Imibukiso Yokucwaninga
Ucwaningo olwandulelayo luye lwabonisa ukuthi izinga eliphezulu le-LDH lingakwazi ukubikezela ukusinda kuziguli ezine-melanoma ephakeme. Ngenxa yalesi sizathu, i-LDH ifakwe ohlelweni luka-2002 lwe- melanoma. Iziguli ezine-stage IV ye-melanoma ne-LDH ephakeme zinokubikezelwa okubi kakhulu .
Ngaphandle kokuhlukanisa iziguli ezinegciwane lesigaba se-IV, ukuhlolwa kwe-LDH akuyona into eqondile noma ezwelayo ngokwanele ukuthola i-melanoma ngaphambi kokuba ihambisane nezidakamizwa ze-lymph. Ucwaningo lulandelwe iziguli ezine-melanoma iminyaka engu-2.5 emva kokuhlinzwa.
Imiphumela yabonisa ukuthi izinga le-LDH alilona uphawu oluhle "olwenziwe imetasasisi yezokuthutha" (isigaba se-IIIC melanoma esasakaze ngaphesheya kwesikhumba sesikhumba kodwa hhayi emalini yesikhumba) noma sisakazeka kumakamelo omzimba wendawo. Esicwaningweni, ukuhlolwa kwe-LDH kwacacisa ngokuqondile imetastasis eseduze embalwa yeziguli. Isivivinyo somunye amaprotheni wegazi okuthiwa yi-S-100B siphumelela njengesimakethe esingcono kuneLDH futhi singase sibe nezinhlelo ezizayo.
Uma udokotela wakho ecele ukuhlolwa kwe-LDH, noma noma ngabe imiphumela ibuye futhi izinga liphakeme, ungethuki. Izinga eliphakeme le-LDH alisho ukuthi i-melanoma yakho iye yenzeke kahle, "kuphela" ikhanda lakho ukuze udokotela wakho aphenye ngalesi simo nge- CT, PET, noma i-MRI scan noma i-sentinel lymph node biopsy.
Uma unemibuzo noma ukukhathazeka mayelana nokuhumusha imiphumela yakho yokuhlolwa kwe-LDH, qiniseka ukuxoxa nabo nodokotela wakho.
> Imithombo:
> I-Egberts F, i-Hitschler WN, i-Weichenthal M, i-Hauschild A. "Ukuqapha okulindelekile ukwelashwa kwe-adjuvant kuma-melanoma abagula kakhulu: i-lactate dehydrogenase namaprotheni S-100B njengezibonakaliso zokuphindaphinda" I- Melanoma Research 2008.
> Chun YS, Wang Y, Wang DY, et al. "Inani leprognostic lamazinga e-S100B namazinga e-LDH ezigulini ze-melanoma" J Clin Oncol 2008 26 (May 20 suppl; Abstr 9002).
> I-Eggermont AMM. "Ukufinyelela IsiSekelo Sokuqala Esikhathini Sokwelashwa KweMetanoma" J Clin Oncol 2006 24 (29): 4738-45.