I-Link Phakathi kwe-Aspirin ne-Asthma
Abantu abaningi abacabangi kabili mayelana nokuphuma kwe- aspirin uma benesifo sekhanda. Kodwa kwabanye abantu abane- asthma , le remedy elula ingabulala.
Iyini i-Aspirin-I-Asthma Ekhishwe?
I-aspirini nezinye izidakamizwa ezingezona ukuvuvukala ( non-inferoidal anti-inflammatory drugs ) (i-NSAIDS) njenge- ibuprofen , naproxen, ne-diclofenac zitholakale zenza ukuhlasela kwe-asthma kubantu abane-asthma.
Ukuhlaselwa kwe-asthma okubangelwa i-aspirin ne-NSAIDS ngokuvamile kuvame futhi kungasongela ukuphila. Uzwela lwe-aspirin lubonakala landa njengoba abantu bekhula, futhi kubi nakakhulu kubantu abane-asthma eyingozi kakhulu.
Le syndrome iye yaqaphela iminyaka eminingi, kodwa kwakungacaci ukuthi bangaki abantu abane-asthma babhekene nobungozi lapho bethatha le mithi evame ukusetshenziswa kuze kube yilapho kuqhutshwa izifundo kulo.
Ucwaningo olukhulu luka-2004 lubuyekeze izifundo ezenziwe nge-asthma eyenziwe nge-aspirin (i-AIA okwesikhashana). Abacwaningi bamangala lapho bethola ukuthi amaphesenti angu-5 ezingane abane-asthma namaphesenti angu-21 abantu abadala abane-asthma bangenwa yi-AIA.
Imiphumela yalolu cwaningo ibalulekile ngoba abantu ababandakanyekile "empeleni babe" inselele "nge-aspirin esimweni esilawulwayo, okwenzela ukulinganisela okuqondile kunani labantu abangathinteka yi-AIA. Le ndlela yokuqhuba lolu cwaningo yanciphisa amathuba okuba abantu baveze ukuthi ukuhlasela kwabo nge-asthma kulesi sifo ababethatha i-aspirin, into abacwaningi abaphetha yenzeke njalo.
Eqinisweni, uphenyo wathola ukuthi lapho abantu bebuzwa ukuthi babike ukuhlaselwa kwe-asthma kwangaphambi kwe-aspirin, izinga leempendulo ezimpumelelo kwakungamaphesenti angu-2.7 kuphela.
Kungani I-Aspirin Ngezinye izikhathi Kungenxa yokuthi i-Asthma ihlasela?
Odokotela nabacwaningi ekuqaleni babekholelwa ukuthi lesi senzakalo sasiyiphundu le-aspirin.
Kodwa-ke, manje sekukholelwa ukuthi i-aspirin ibangela ukuhlasela kwe-asthma kwabanye abantu ngoba i-aspirin isebenza njenge-regulator of leukotrienes. I-leukotrienes yizinto ezitholakala emzimbeni ezibangela ukuvuvukala nezinambuzane eziningi ze-asthma.
Ingabe Kukhona Izikhungo Zase-Aspirin Eziphephile Kubantu Abano-AIA?
Abantu abane-AIA nabo bangengozi yokuphendula nge-asthmatic ku-NSAIDS, okuyinto odokotela abavame ukuyala abantu abaphikisana ne-aspirin. Ucwaningo luye lwabona ukuthi cishe bonke abantu - okungukuthi abanayo i-AIA nabo basabela ngendlela engafanele kwi-NSAIDS. Amathuba okuba nokuhlaselwa yisifo se-asthma kwaba mkhulu kubantu ababesabela ngisho nasezincane ze-aspirin.
Iziguli ezine-AIA nazo zavivinywa ukuze zibone ukuthi zingasabela kanjani ku-acetaminophen (iTylenol), esinye isifakela esivamile se-aspirin. Ngalo muthi, amaphesenti angu-7 kuphela abantu abane-AIA babene-reaction asthmatic. Nakulokhu, labo abathinteka kakhulu ku-aspirin babengase basabele nakakhulu ne-acetaminophen.
Esinye isigaba semithi yokuphumula ebuhlungu, ama-cyclooxygenase-2 (COX-2) ama-inhibitors anama-inflammatory njenge-celecoxib (i-Celebrex), enza ngendlela ekhethekile yokulwa nokuvuvukala kune-aspirin ne-NSAIDS. Ngenxa yokuthi lezi zidakamizwa zinesisindo esincane emgwaqweni wokuvuvukala, kubonakala sengathi asiba nomthelela ofanayo kubantu abane-asthma.
Nakuba i-COX-2 inhibitors engenawo umphumela omubi wokuvimbela ukuhlaselwa yisifo se-asthma njenge-aspirin ne-NSAIDS, izidakamizwa ezivimbela i-COX-2 zingandisa ingozi yokuhlaselwa yinhliziyo nokushaya isifo. Abantu abane-AIA futhi abadinga imithi elwa nokuvuvukala kufanele bakhulume nodokotela wabo mayelana nezingozi nezinzuzo ze-celecoxib.
Ukwelapha Nokuvinjelwa Kwe-Aspirin-I-Asthma Eyaziwayo
Abantu abane-AIA bathambekele ekuthuthukiseni izimpawu zingakapheli imizuzu engama-30 ukuya emahoreni amabili ngemuva kokuthatha i-aspirin noma i-NSAIDS, kanti ubunzima obangela ukuphefumula kungase kuphele amahora. Ukwelashwa kufana nalokhu kunoma yikuphi ukuhlaselwa kwe-asthma okuphawulekayo - ukusindisa okusheshayo-ukusiza inhaler, ne-oksijini kanye ne-steroids ngezibonakaliso ezinzima.
Ama-modifiers e-leukotriene enye uhlobo lwemithi ye-asthma engase ithuthukise izimpawu ezigulini ezine-aspirin. Ngenxa yokuthi le mithi imisa izenzo ze-leukotrienes, eziye zaboniswa ukuthi zidlala indima enkulu e-AIA, lezi zidakamizwa, kanye nama-steroids angenayo, ngokuvamile ziqondiswe kubantu abane-AIA.
Indlela engcono kakhulu yokuvimbela ukuhlasela kwe-asthma eyenziwa yimithi ukugwema ngokuphelele i-aspirin ne-NSAIDS. Abantu abane-asthma futhi abaqiniseki ukuthi basabele yini ku-aspirin esikhathini esidlule kufanele babuze udokotela uma kuphephile ukuhlola ukuzwela ku-aspirin ne-NSAIDS. Lokhu kufanele kwenziwe kuphela esimweni esilawulwayo ngenxa yengozi yokuphendula okukhulu.
Abantu abane-sensitive aspirin / NSAID abadinga ukuthatha imithi ye-aspirin noma imithi elwa nokuvuvukala ukwelashwa kwezinye izimo, njengezifo zenhliziyo noma izifo ze-rheumatic, kunconywa ukuthi bathole ukuxoshwa kwe-aspirin. Lokhu kungenziwa ngudokotela ogxile ekutheni i-allergies ne-immunology. Uma le nqubo iqhutshiwe, kubalulekile ukuthi umuntu aqhubeke ethatha i-aspirin nsuku zonke, ngakho uzohlala engahleleki.
Imithombo:
Gyllfors, P., et al. Ubufakazi bezinto ezinokwemvelo kanye nomtholampilo ukuthi izihloko ze-aspirin-ezingenelungelo lokuziphendukela kwemvelo zibekezelela i-cyclooxygenase 2-ekhethiwe i-analgesic drug celecoxib. J Allergy Clin Immunol . 2003 Meyi; 111 (5): 1116-21.
Jenkins, C., Costello, J., & Hodge L. Ukubuyekezwa kwesistimu yokusabalalisa kwe-aspirin kwenza i-asthma yenzeke kanye nemiphumela yalo emtholampilo. " BMJ 2004 Feb 21; 328 (7437): 434.
Macy, E., et al. Inselelo ye-Aspirin kanye nokungafuni ukuhlaselwa kwe-aspirin-isifo esiphezulu sokuphefumula: Umkhuba. Ann Ukuzivocavoca Isifo Somoya Immunol. 2007 Feb; 98 (2): 172-4.
I-National Heart Lung ne-Blood Institute. UMnyango WezeMpilo waseMelika kanye Nezinsizakalo Zabantu, amaNational Institutes of Health. (Agasti 2007). Umbiko wePhaneli Wabachwepheshe 3: Izinkombandlela Zokuthola Ukuhlolwa Nokuphathwa Kwe-Asthma: Umbiko Ogcwele 2007 .