Ukuhlolwa kwegazi okuhlolisisa kusiza ukubikezela imiphumela yezempilo
Ukulinganisa ama-CD4 T-cell kubalulekile ekusizeni odokotela ukuba banqume isigaba futhi cishe umphumela wokutheleleka nge-HIV. Nakuba bengasasetshenziselwa ukunquma ukuthi uma ukwelapha i-HIV kufanele kuqalwe kanjani-ukwelashwa kufanele kuqalwe ngesikhathi sokuxilongwa -ngabanikeza odokotela umbono ocacile wokuthi umuntu ungubani nokuthi yini engenziwa ukuze kuthuthukiswe isikhathi eside impilo.
Ukuqonda ama-CD4 nama-CD8 T-Cell
Ukuze uqale, i-lymphocytes yimihlobo yegazi elimhlophe elisiza umzimba ukuba ulwe nokutheleleka. Kunezinhlobo ezimbili eziyinhloko ze-lymphocytes: i-B-lymphocytes kanye ne-T-lymphocytes. Kulezi, kunezinhlobo ezimbili zama-T-amaseli esiwaqaphayo phakathi nenkathi yokutheleleka nge-HIV:
- Ama-CD4 T-cell angama-T-lymphocyte anama-molecule abizwa nge-CD4 ebusweni bawo. Baqala ukuphendula ngomzimba ngokufaka amanye amasosha omzimba avikelayo ukuze ahlaselwe amagciwane njengama-bacteria namagciwane.
- Ama-CD8 T-cell anemamoleli ebusweni bawo okuthiwa i-CD8. Lawa angama-T-lymphocytes "abulala" asebenza ngokubhubhisa amangqamuzana afikelwe ukwelashwa nokukhiqiza izidakamizwa ezilwa nokulwa nezifo ezithathelwanayo.
Inani le-CD4 Count Absolute
Ukubala okuphelele kwe-CD4 kungumlinganiso wendlela amangaki ama-CD4 T-cell asebenzayo egazini lakho. Ukunciphisa inani eliphelele le-CD4, okubuthakathaka ukuphendula komzimba.
Ukubala kwe-CD4 ngokuphelele kulinganiswa nokuhlolwa kwegazi okulula, imiphumela ebizwa ngokuthi inani lama CD4 amangqamuzana ngamamithamitha ayi-cubic millimeter yegazi. Abantu abangenayo i-HIV banamanani aphelele e-CD4 phakathi kwama-600 no-1200 ama-CD4 amangqamuzana ngamamithamitha ayi-cubic. Ngokuphambene nalokho, abantu abanegciwane lesandulela ngculaza abanesifo sengculaza bayela okungenani ngaphansi kwama-500, kuye ngesiteji sokutheleleka, kanti abantu abanesandulela ngculaza bangaba namasentimitha angu-200 noma angaphansi kwe-CD4 T-cubic millimeter.
I-CD4 count ngokuphelele ibhekwa njengethuluzi elingcono kakhulu lokubikezela ingozi yokuqhubekela phambili kwe-HIV.
Lokho i-CD4 Percentage isitshela yona
Iphesenti le-CD4 limelela iphesenti yama-lymphocyte ephelele angama-CD4 amangqamuzana futhi kulinganiswa ngokusebenzisa ukuhlolwa kwegazi okufanayo njengaleyo inani le-CD4 ngokuphelele.
Ngokuvamile, abantu abangenayo i-HIV bazoba namaphesenti angu-CD angama-40 amaphesenti, kanti amaphesenti angama-CD4 abantu abanesandulela ngculaza angase aphansi njengama-25 amaphesenti noma ngaphansi. Ngokusobala, ukuphakama kwephesenti kuphakeme, ukuphendula okuningi kwamagciwane okunamandla.
Uma inani lakho le-CD4 liphansi kunalokhu ulindele, amaphesenti e-CD4 angayifaka embonweni engcono ngokutshela lokhu ukuthi lokhu kunguquko yangempela noma nje ukushintshashintsha.
Ukulinganisa i-CD4 / CD8 njengeSpapshot of Health Immune
Enye indlela yokuthola ukuqonda okungcono kwesiguli somzimba wegciwane ukuhlolisisa i- CD4 / CD8 yephesenti isiguli , ehlola inani lamaCD4 T-cell ngokuqhathaniswa nenani lama-CD8 T-cell. Ngesivivinyo, singabona ukuthi lesi sifo sithuthuka ngokulandela ukuchithwa kwe "killer" T-cells kuma-sampuli egazi.
Ngokuvamile, ekuthuthukiseni izifo, njengoba isimiso somzimba sokuzivikela sikhathele , asikwazi ukukhiqiza ama-T-cell ukuzivikela. Iphesenti le-CD4 / CD8 lisisiza sibone lokhu.
Eminyakeni yamuva, kugcizelelwe kakhulu kwi-CD4 / CD8 enamandla kubantu asebekhulile be-HIV . Ucwaningo lwamuva lwezempilo luphakamisa ukuthi iziguli ezisebenza nge-ART esebenzayo, ephansi isikhathi eside ngezinga eliphansi le-CD4 / CD8 zinomngcipheko okhulayo wokungabhubhi nokufa kwabantu okungenalo i-HIV.
Okwenza lezi zivivinyo zibalulekile
Inani le-CD4 eliphelele kanye namaphesenti e-CD4 anika udokotela wakho isifinyezo sempilo yesimiso sakho somzimba omzimba, kanye nokuchazwa kwesifo sakho ukuqhubekela phambili.
Ngendlela elula kakhulu, siyazi ukuthi izibalo ze-CD4 ezingaphansi kuka-200 zibeka umuntu onesandulela ngculazi engozini yezifo ezithatha amathuba . Iphesenti le-CD4, okwamanje, lihlolisisa inani eliphelele lama-lymphocyte futhi libikezela kakhulu impilo yomuntu esheshayo nesikhathi eside.
Uma, isibonelo, isibalo se-CD4 sikhulu ngoba kuphela inani le-lymphocyte liphakeme, sisazoba nesisusa sokukhathazeka ngempilo yesiguli. Uma, ngakolunye uhlangothi, i-CD4 iyancipha ngenxa yesibalo esincane se-lymphocyte, singakwazi ukuhumusha imiphumela ngokuhlukile.
> Umthombo:
> Gompels, M .; Dunn, D .; Phillips, A .; et al. "Ingabe ukuhlukunyezwa phakathi kwe-CD4 Count ne-CD4 Percentage kubantu abane-HIV-positive kubangelwa yimiphumela yokwelashwa kwama-antiretroviral ephezulu?" I-Disfect Dis Dis. 2012; 205 (4): 540-547.
> Sauter, R .; I-Huang, R .; Ledergerber, B .; et al. "Isibalo se-CD4 / CD8 nesilinganiso se-CD8 sichaza ukuphendula kwe-CD4 ku-HIV-1 elinegciwane lesandulela ngculazi kanye neziguli eziphethwe umkhuhlane." Imithi. 2016; 95 (42): e5094.