I-resin ephuzi efihliwe ngumuthi we-mukul myrrh ( Commiphora mukul ), i-guggul isetshenziswe izinkulungwane zeminyaka ku- ayurveda (umuthi wendabuko we-India). Abahlinzeki bemithi ye-ayurvedic bavame ukuhlanganisa ukukhishwa kwe-guggul nezinye izinto zemvelo ukuphulukisa izinkinga zempilo ezifana ne-arthritis, i-hemorrhoids, kanye nokutheleleka kwe-urinary tract. I-Guggul iphinde isetshenziswe njengesiluleko se-acne, kanye nesisindo sokulahlekelwa kwesisindo.
Izinzuzo zezempilo zikaGuggul
Kuze kube manje, ukwesekwa kwesayensi ngezinzuzo ze-guggul kuyabikho.
1) Cholesterol ephezulu
Nakuba i-guggul isetshenziswa kakhulu eNdiya ukulwa ne-cholesterol ephakeme, ucwaningo ngemiphumela ye-cholesterol-ukwehlisa imithwalo ye-extract yenze imiphumela ehlanganisiwe. Ucwaningo lwango-2009 lwabantu abadala abangama-43 abane-cholesterol ephakeme ngokwemvelo, isibonelo, bathola ukuthi labo abathatha ama-2,160 mg weguggul ngohlobo lwe-capsule nsuku zonke babe nehla elikhulu kunazo zonke emazingeni e-cholesterol kunabo abathatha ipilisi ye-placebo. Kodwa-ke, amalungu okutadisha abasebenzisa i-guggul awabonanga ukunciphisa okukhulu emazingeni abo e-LDL ("okubi") i-cholesterol.
Esinye isifundo, eshicilelwe ngo-2003, sabelwa abantu abadala abangu-103 abane-cholesterol ephakeme ukuthatha u-1,000 mg noma u-2 000 mg weguggul nsuku zonke amasonto ayisishiyagalombili futhi bathola ukuthi ukukhishwa kwamambala kwaphakamisa amazinga e-LDL cholesterol.
Okuningi: ukwelashwa kwemvelo ukunciphisa i-cholesterol .
2) Izicubu
Ucwaningo lokuqala luveza ukuthi ukukhishwa kwe-guggul kungasiza ekulwa nezidumbu.
Ucwaningo olulodwa lwama-2007 ngamangqamuzana omuntu lathola ukuthi i-guggulsterone (i-compound etholakala ku-guggul) yenze ukufa kwama-cancer omzimba wesifo sofuba, kanti umbiko we-2008 uveze ukuthi i-guggulsterone yavimbela ukukhula kwezicubu zesikhumba emagundwini.
3) i-Osteoarthritis
Olunye ucwaningo lubonisa ukuthi ukukhishwa kwe-guggul kungasiza ukunciphisa izimpawu ze-osteoarthritis emadolweni.
Funda ngezindlela zokwelapha zemvelo ze- osteoarthritis .
Amapulangwe
Ukukhishwa kwe-Guggul kungase kubangele imiphumela emibi njengekhanda, inhlayiya, nokucasula isikhumba (ngokuvamile ngesimo sokuqhuma) kwabanye abantu. Njengoba i-guggul nayo itholakale ukugqugquzela i-thyroid, noma ubani onenkinga yegciwane kufanele abonane nodokotela ngaphambi kokusebenzisa i-guggul extract.
Esicwaningweni sika-2004, ososayensi bathola ukuthi i-guggulsterone ingavimbela isenzo sezidakamizwa ezihlanganiswa yi-enzyme ye-CYP3A yomzimba. Lezi zidakamizwa zihlanganisa i-Lipitor, i-cyclosporine, ne-quinidine.
Izindleko azange zihlolwe ukuphepha futhi ngenxa yokuthi izithako zokudla ngokuvamile azihambisani nomthetho, okuqukethwe kwemikhiqizo ethile kungase kuhluke kulokho okushiwo kwilebula lomkhiqizo. Futhi khumbula ukuthi ukuphepha kwezidakamizwa kwabesifazane abakhulelwe, omama abahlengikazi, izingane, nalabo abanezimo zezokwelapha noma abaphuza imishanguzo abazange basungulwe. Ungathola amathiphu ekusebenziseni izithako lapha , kodwa uma ucabangela ukusetshenziswa kwe-guggul, khuluma nomhlinzeki wakho wokunakekela oyinhloko kuqala. Ukwelapha isimo futhi ukugwema noma ukubambezela ukunakekelwa okujwayelekile kungaba nemiphumela emibi.
> Imithombo:
> Brobst DE, Ding X, Creech KL, Goodwin B, Kelley B, Staudinger JL. "I-Guggulsterone ivuselela i-Multiple Nuclear Receptors kanye ne-Induces cyp3a i-Gene Expression ngokusebenzisa i-Pregnane X Receptor." I Journal of Pharmacology and Experimental Therapeutics 2004 310 (2): 528-35.
> Nohr LA, uRasmussen LB, Straand J. "I-Resin Evela Emthonjeni We-Myrrh, i-Guggul, ingabe ingasetshenziswa ekuphatheni i-Hypercholesterolemia?" Isifundo Esingahleliwe Esilawulwa Ngolwazi. "Imithi Ephelele Ekudleni 2009 Jan; 17 (1): 16-22 .
> Sarfaraz S, Siddiqui IA, Syed DN, Afaq F, Mukhtar H. "I-Guggulsterone ihambisa i-MAPK ne-NF-kappaB eNdlela futhi ivimbela i-Tumorigenesis yesikhumba emasimini aseSENCAR." I-Carcinogenesis 2008 29 (10): 2011-8.
> Singh BB, Mishra LC, Vinjamury SP, Aquilina N, Singh VJ, Shepard N. "Ukuphumelela kwe-Commiphora Mukul ye-Osteoarthritis ye-Knee: > i > Izifundo zokuPhumela." Ezinye izindlela zokwelapha ezempilo nemithi 2003 9 (3): 74-9.
> Singh SV, Choi S, Zeng Y, Hahm ER, Xiao D. "I-Guggulsterone-Induced Apoptosis e-Human Prostate Cancer Amaseli Ayenziwa Ngu-Oxygen Osebenzayo Osebenzelana Nokusebenza Okusebenzayo kwe-c-Jun NH2-Terminal Kinase." Ucwaningo lwe-Cancer 2007 1; 67 (15): 7439-49.
> Szapary PO, Wolfe ML, Bloedon LT, Cucchiara AJ, DerMarderosian AH, Cirigliano MD, Rader DJ. "Guggulipid for the Treatment of Hypercholesterolemia: Isivivinyo Esilawulwe Ngokungahleliwe." I-JAMA 13; 290 (6): 765-72.