Imiphumela ye-Statin Faka izindawo eziphikisana nokuvuvukala, ezinye izinzuzo
Izitembu ezinqunywe yi-cholesterol efana ne-Lipitor (atorvastatin) ne-Crestor (rosuvastatin calcium) ziphakathi kwezidakamizwa ezibekiwe kakhulu emakethe namuhla. Inhloso yabo ukwehlisa i-cholesterol yegazi ngokunciphisa inani le-cholesterol elikhiqizwa yisibindi, kodwa lineminye eminye imiphumela. Ngokusetshenziswa okuvamile, abakwazi nje ukwehlisa "i-cholesterol embi" (i- LDL ) kodwa namazinga we- triglyceride .
Bangakwazi ukuthuthukisa amazinga akho "we-cholesterol" (i- HDL ), futhi.
Ucwaningo luye lwabonisa ukuthi umphumela wokunakekelwa kwama-statins nge-cholesterol kungenzeka ukuthi awusizo kuphela. Ukwelashwa kwe-statin uye wabonisa isithembiso sayo yonke into ekulwa nokutheleleka kwegciwane ukuze kuvikelwe iso kusuka ekuguleni.
Izakhiwo eziphikisanayo zokuvuvukala zezitatimende
Njenge-cholesterol, ukuvuvukala kwemithambo ye-coronary ingenye yezici eziningana ezingabangela ukuhlaselwa kwenhliziyo nokushaya. Iprotheyini esebenzayo ye-C (CRP) iyimakaki eyisihluthulelo yalokhu ukuvuvukala okulimazayo, nokusetshenziswa kwesimo se-statin kusiza amazinga aphansi e-CRP.
Ucwaningo olwanyatheliswa ngo-2007 lubuyekeze imiphumela yezilingo eziningana zomtholampilo ezibandakanya iziguli ze-angioplasty ezithatha iziqu. Ithole ukuthi amazinga e-CRP ayebasiza kakhulu njengamazinga "ama- cholesterol amabi " ekubikezeleni ingozi yeziguli zezenzakalo zenhliziyo eziphindaphindiwe.
Imithi ye-Antiviral kanye ne-Antibacterial of Statins
Omunye wemiphumela emangalisa kakhulu yokusetshenziswa kwesimanje kwaba yindawo ebonakalayo yokulwa nezigciwane.
Ucwaningo lwango-2004 lwamaCanada lathola ukuthi izitembu zanciphisa ukunamathiswa kwegciwane lesandulela ngculazi kumaseli angasetshenziswa.
Ucwaningo olwenziwa ngo-2005 lweziguli ezingaphezu kuka-700 esibhedlela oluphathwa nge- pneumonia lithola ukuthi izinga lokufa laliphindwe kabili ngaphezu kwalabo ababengasebenzisi statins.
Ngo-2006, ucwaningomunye waseCanada luhlola izinga le- sepsis , ukutheleleka kwegazi okubulalayo, phakathi kweziguli ezazibekwe esibhedlela ngenxa yezenzakalo zenhliziyo.
Eminyakeni emibili ngemuva kokubelethwa kwabo esibhedlela, abasebenzisi be-statin babe nesilinganiso se-19% esingaphansi kwesabasebenzisi abangewona abakwa-statin.
Ukubuyekezwa kuka-2009 kwezifundo ezingu-22 kutholakale ukuthi izitembu zibonakala ziba nethonya elihle emphumela wokutheleleka, kepha azikwazi ukufika esiphethweni esiqinile.
Izitatimende zingase zinciphise ukucindezelwa kwegazi kancane
Ukusetshenziswa kwe-Statin kubonakala kunciphisa ukucindezelwa kwegazi, nakuba nje ngokuthobeka, okungenakwanele ukuphikisana nemishanguzo yegazi ekhona.
Ucwaningo lwaseBrithani ngo-2007 lubike ukuthi phakathi kwabasebenzisi be-statin, ukufundwa kuncishiswe ngo-1.9 mmHg we-systolic blood pressure kanye ne-0.9 mmHg ye-diastolic yegazi. Lezi zinyunithi zokulinganisa kwezingcindezi zegazi zimelelwa "inombolo yokuqala" noma "inombolo ephezulu" ebonisa ukufundwa kwe-systolic kanye nenombolo "yesibili" noma "ngezansi" ebonisa ukufundwa kwe-diastolic. Ezigulini ezinegazi legazi elaqala kakhulu, izitho zomzimba zavela ukuveza ukwehla kwe- 4.0 mmHg ekucindezelekeni kwe-systolic .
Ukufunda I-Fibrillation Yase-Atrial Ngemva Kokuhlinzwa Kwezinhliziyo
I-fibrillation ye-atrial (AF) yintliziyo engavamile eyenzeka ngokujwayelekile emva kokuhlinzwa kwenhliziyo. Lokhu kungabangela ukuhlala esibhedlela isikhathi eside noma ngisho nemivimbo noma ukuhluleka kwenhliziyo. Ngocwaningo luka-2006, iziguli ezanikezwa isonto elide lezintambo ngaphambi kokuhlinzwa zineengozi engaphansi kuka-61% ye-AF.
Izifo Zama-Alzheimer Ukuvikelwa Kwezitembu Akuvunyelwe
Obunye ubufakazi bubonisa ukuthi ukwelashwa kwesimiso kungavimbela ukuqhubeka kwesifo se- Alzheimer . Esifundweni sika-2007. Ucwaningo olwanyatheliswa ngonyaka odlule, kodwa lwalandela iziguli eziphila eminyakeni engaphezu kwengu-12, alutholanga umehluko omkhulu emazingeni e-Alzheimer phakathi kwalabo abathatha izitembu nalabo ababengenalo. Ukubuyekezwa kuka-2014 kwezifundo ezine, kufaka phakathi izilingo ezimbili ezilawulwa ngokungahleliwe okungahleliwe, akutholakalanga ubufakazi bokuthi izitembu zasiza ekunciphiseni kwengqondo ekunciphiseni ukucindezeleka.
Ingabe Izitatimende Zifanele Kuwe?
Uma une-cholesterol ephakeme, udokotela wakho angakunikeza isidakamizwa se-statin.
Noma kunjalo, ama-statins angase angafaneleki wonke umuntu, ngakho-ke khuluma naye ngokuthi ngabe kufanele yini noma kunjalo, yini, nokuthi yiziphi ezinye izinketho zakho zokwelapha.
Imithombo:
UMcGuinness B, Craig D, Isibhamu R, i-Malouf R, i-Passmore P. "Izitatimende zokwelashwa kwengqondo." Database Cochrane Yokuhlolwa Okuhlelekile 2014, Issue 7. Art. Inombolo: CD007514. I-DOI: 10.1002 / 14651858.CD007514.pub3
Chan, Albert W., Deepak L. Bhatt, uDerek P. Chew, uJoel Reginelli, uJakob P. Schneider, u-Eric J. Topol, uStephen G. Ellis. "Ukukhulumisana nokuvuvukala kanye nenzuzo yamaSitatimende Ngemuva kokungenelela kweCononary Percutaneous." Ukujikeleza . 107: 13 (2003): 1750-56. 29 Septhemba 2008
UGiguere, uJean-Francois, uMichel Tremblay. "I-Statin Compounds iyanciphisa i-Virus Type 1 Replication ngokuvimbela ukusebenzisana phakathi kwe-Virion-Associated Host Intercellular Adhesion Molecule 1 ne-Surface Cell Surface Ligand LFA-1." Journal of Virology . 78 (2004): 12062-12065.
Hackam, D, M. Mamdani, D. Redelmeier. "Izitatimende Ne-Sepsis Ezigulini Eziphethwe Yizifo Zezinhliziyo: Ukuhlaziywa Kwamaqembu Aphethwe Abantu." I-Lancet . 367: 9508 (2006): 413-18. 29 Septhemba 2008
P Kopterides no ME Falagas. "Izitatimende ze-sepsis: ukubuyekezwa okubucayi nokuvuselelwe." C linical Microbiology kanye Infection 2009; 15 (4): 325-334.
"Ukuvuvukala, Izifo Zenhliziyo Ne-Stroke: Indima Yeprotheni Esebenzayo." americanheart.org . 2008. American Heart Association. 29 Septhemba 2008
Kumar, Amit, uChristopher Cannon. "Ukubaluleka Kwe-Lipid Ejulile Yehlelwa E-Coronary Syndrome Eyinkimbinkimbi kanye Nokungenelela Kwe-Coronary Percutaneous." I-Journal of Cardiology Interventional. 20: (2007): 447-57. 29 Septhemba 2008
Mortensen, Eric M., MI Restrepo, A. Anzueto, J. Pugh. "Umphumela We-Statin Yokuqala Okusetshenziselwa Ukushona Kwezinsuku ezingu-30 zeziguli." Ucwaningo lokuphefumula . 6: 1 (2005): 82. 29 Septhemba 2008.
UPatti, G., Massimo Chello, uDario Candura, uVincenzo Pasceri, u-Andrea D'Ambrosio, u-Elvio Covino, uJalimano Di Sciascio. "Ukuhlolwa Okungenakulinganiswa Kwe-Atorvastatin Yokunciphisa Amafibrillation E-Postrialative Atrial in Iziguli Ezihlinzwa Ngokuhlinzwa Kwezinhliziyo." Ukujikeleza . 114: 14 (2006): 1455-461. 29 Septhemba 2008
U-Strazzullo, uP., uSally M. Kerry, u-Antonio Barbato, uMarco Versiero, u-Lanfranco D'Elia, uFrancesco P. Cappuccio. "Ingabe Izitatimende Zenza Ukunciphisa Ukucindezelwa Kwegazi? I-Meta-Ukuhlaziywa Kwezinguquko Ezingahleliwe, Ezivikelwe." I-hypertension . 49: 4 (2007): 792-829. 29 Septhemba 2008