Imiphumela emibi, izixwayiso, nolunye ulwazi olubalulekile
I-Simponi (i-golimumab) uhlobo lomuthi owaziwa njenge-TNF-alpha (i- tumor necrosis factor alpha blocker). Kutholakale ukuthi i-TNF idlala indima ekuthuthukiseni isifo sofuba esiswini (IBD). I-TNF itholakala ngemali ephakeme emakholoni abantu abane-ulcerative colitis nesifo sikaCrohn kunabantu abangenawo uhlobo lwe-IBD.
Ngokuvamile, njengezinye izidakamizwa ze-immune ezisetshenziselwa ukuphatha i-IBD, zibophezela ku-TNF-alpha futhi zivimbela ukuba zisetshenziswe ngomzimba. Lesi sidakamizwa sakhiwa yiJanssen Biotech.
Abacwaningi bacabanga ukuthi i-TNF-alpha inendima ku-IBD nasesimisweni sesisu. I-IBD yisimo sokuvuvukala, futhi i-TNF-alpha ingumthumeli wamakhemikhali owaziwa ngokuthi i- cytokine . I-cytokines ayinikezi kuphela "imilayezo" phakathi kwamaseli emzimbeni, kodwa futhi ayingxenye ekukhuthazeni inqubo yokuvuvukala.
I-Simponi Taken kanjani?
I-Simponi inikezwa njenge-injection ngaphansi kwesikhumba. Ngemuva kokuqeqeshwa uchwepheshe wezempilo, iziguli zikwazi ukuzinikela nge-Simponi injection ekhaya. Izijovo zizovela neziyalezo eziningiliziwe ekusebenziseni kwabo, kanti udokotela ozohlinzeka uzohlinzeka noma yiziphi ezinye iziyalezo ezikhethekile iziguli okufanele zilandele. Ukuze uqale Simponi, kunezijovo ezimbili zokuqala. Okulandelayo, injection engu-1 inikezwa ngamasonto amabili kamuva.
Futhi-ke, ukuze isondlo, i-Simponi injection inikezwa njalo emva kwamasonto amane.
Ukusetshenziswa
I-Simponi ivunyiwe ukuphatha ukwelapha okulondekayo okulindelekile kuya kwesimweni ezimweni ezingazange zamukele imithi ejwayelekile (ayisetshenziswanga njengendlela yokuqala yokwelashwa kwalesi simo). I-Simponi nayo ivunyelwe ukwelapha isifo samathambo , i-psoriatic arthritis, ne-ankylosing spondylitis.
I-Simponi isebenza ukuvimbela ukuvuvukala ngokuzibophezela ku-TNF-alpha. Uma i-TNF-alpha ingasatholakali ukubangela ukuvuvukala, i-IBD ingangena esikhathini sokuxolelwa (uma umsebenzi wezifo kanye nezimpawu zikhona).
Ubani Okungafanele Athole Kulula?
Tshela udokotela wakho uma uphathwe isifo, uma uyithwala wegciwane lesifo se-hepatitis B, usanda kuthola umgomo wokuphila, noma uke wabhekana nokuziphendulela ku-Simponi.
Okuqhamuka uma udla imishanguzo
Imiphumela emibi evamile ye-Simponi ihlanganisa ukutheleleka okuphezulu kokuphefumula, ukusabela kwendawo yomjovo (njengokubomvu noma ukuvuvukala), nokutheleleka ngegciwane lesandulela ngculazi njengesifo somkhuhlane kanye nezilonda ezibandayo . Tshela udokotela wakho ukuthi ngabe yimiphi imiphumela emibi ihlupha noma ungahambi. Lemiphumela emibi kufanele ibikwe kudokotela wakho ngokushesha.
Ezinye izixwayiso Ezenzweni ezimbi
I-Simponi nezinye izinhlobo ze-TNF-blocker ziye zahlotshaniswa nezinhlobo ezithile zokutheleleka, kuhlanganise nesifo sofuba. Noma yikuphi ukungcola komuntu onesifo sofuba kumele kubikwe kudokotela ochaza. Iziguli ezithatha ukwelapha nge-Simponi kufanele zihlolwe isifo sofuba (kufaka phakathi isimo esibi selesi sifo), futhi sithole ukwelashwa uma kunesidingo. Uma uthatha lesi sidakamizwa, iziguli kufanele zihlolwe futhi ngezibonakaliso noma izimpawu zesifo sofuba, njenge:
- Ubuhlungu besifuba
- Isikhukhula
- Fever
- Ukulahlekelwa kwesifiso
- Izithukuthuku ebusuku
- Ukulahlekelwa kwesisindo
Ezinye izinhlobo zokutheleleka nazo zingenzeka, njengoba le mithi ikwehlisa ukumelana komzimba kuma-agent aphethwe yizifo ezithathelwanayo. Iziguli eziye zahlala endaweni enezifo eziphezulu zezifo ezifungile noma ezinezinkinga ezikhona manje kufanele zibike lezi zimo kudokotela ochaza i-Simponi.
I-TNF blockers ziye zahlotshaniswa nokuthuthukiswa kwezinhlobo ezithile zegciwane. I-Lymphoma ibike kubantu abathatha ukuvimbela i-TNF. Ngokuqondile, ingozi yokuthuthukisa i-hepatosplenic T-cell lymphoma yanda, ikakhulukazi kumadoda amasha.
I-Simponi iye yahlotshaniswa nokuthuthukiswa komdlavuza wesikhumba . Abantu abasebenzisa i-Simponi kufanele baqaphele noma yiziphi izinguquko esikhumbeni sabo, njengezikhula ezintsha noma ama-moles ashintsha ngombala noma ngesimo.
Abantu abathwala isifo se- hepatitis B basengozini yokuvuselela igciwane lapho bethatha imithi yokulwa ne-TNF. Iziguli ezithatha i-Simponi kufanele zihlolwe ngesifo sofuzo esibhedlela se-B futhi kufanele ziqaphele izimpawu nezimpawu zesifo sofuzo esibhedlela njenge-:
- Ama-Chills
- Ukunyakaza kwamathumbu embala
- Umchamo omnyama
- Ukukhathala okukhulu
- Fever
- Ukungabi nesifiso
- Ama-muscle aches
- Ukuphuza isikhumba
- Ukukhathazeka kwesisu
- Ukuvota
- Isikhumba esincane noma amehlo
Inani eliphansi legazi liye labonwa kwezinye iziguli ezithatha izidakamizwa ezilwa no-TNF. Lokhu ukukhathazeka okhethekile kubantu abane-IBD, abasebevele besengozini yamazinga aphansi amangqamuzana egazi obomvu. Udokotela wakho uzoqapha igazi lakho ngezikhathi ezithile ukuze afune i- anemia .
Ezinye izinkinga ezingase zenzeke ngenkathi zilwa nokwelashwa kwe-TNF zihlanganisa ukuhluleka kwenhliziyo, ukubola kwesibindi, i-Guillain-Barré syndrome, isifo sesibindi, i-psoriasis, nezimpawu ze-lupus-like.
Ukusebenzisana nokudla kwezidakamizwa
I-Simponi ivame ukuthathwa ngokuhambisana nezinye izidakamizwa ezisetshenziswa ukuphatha i-IBD njenge-corticosteroids. Imithi engaxhumana no-Simponi ihlanganisa:
- I-Kineret (yakinra)
- Orencia (abatacept)
- I-Rituxan (rituximab)
- Imishanguzo ephilayo
Akukho ukusebenzisana kokudla okuyaziwayo.
Ukuphepha ngesikhathi sokukhulelwa
I-FDA ihlukanise i-Simponi njengesidakamizwa sohlobo B. Umphumela wokuthi i-Simponi inomntwana ongakazalwa awufundiwe kakhulu. I-Simponi kufanele isetshenziswe kuphela ngesikhathi sokukhulelwa uma kudingeka. Yazisa udokotela ochazayo uma ukhulelwa ngenkathi uthatha i-Simponi. Ayaziwa uma i-Simponi idlula ubisi lwebele, kodwa ezinye izinto ezifanayo ziboniswe ukuthi zidlule ubisi lwebele. Amandla emibi kakhulu emithonjeni kufanele ahlolwe ngokubaluleka kwemithi kumama. Enye indlela ukuyeka ukuncelisa ngaphambi kokuba uqondise i-Simponi.
Imithombo:
I-Janssen Biotech, Inc. "Umhlahlandlela Wemithi Elula." May 2013.
Janssen Biotech, Inc. "I-Simponi Website". May 2013.
U-Olsen T, u-Goll R, uCui G, et al. "Amazinga omzimba we-tumor necrosis factor-alpha correlates nebanga lokuvuvukala emlonyeni we-ulcerative colitis." I-Scand J Gastroenterol . 2007 Nov; 42: 1312-1320.
URoberts-Thomson IC, u-Fon J, u-Uylaki W, uCummins AG, uBarry S. "Amaseli, ama-cytokines nesifo sokukhukhumeza isifo sofuba: umbono wezokwelapha." Uchwepheshe we-Rev Gastroenterol Hepatol . 2011 Dec; 5: 703-716. i-doi: 10.1586 / egh.11.74.