Ukwelashwa Okuphephile Kakhulu, Ukwelashwa Okuphephile Kwe-Migraine Engapheli
Ukwelashwa kwama-migraine angapheli kugxile ekuhlanganyeleni kokungenelela kokuziphatha, njengokugwema ukukhukhumeza, kanye nokwelashwa kwemithi noma izidakamizwa. Nakuba lezi zinyathelo zisebenza kwabanye abantu, ezinye ziphikisana noma zingahambisani nalezi zindlela zokujwayelekile zokunakekelwa. Kulezi zimo, umuntu angase acabange ngemithi eminingi engeyona yendabuko, njengeBotox .
Kuyini i-Botox?
I-OnabotulinumtoxinA, eyaziwa ngegama lokuhweba iBotox, iyisifo esenziwe yi-bacterium Clostridium botulinum futhi isebenza ngokuvimbela ukuxhumeka kwemizwa, okunciphisa umsebenzi we-muscle. I-Botox yamukelwa yi-FDA ngonyaka ka-2010 ukuze kuvikelwe ukwelashwa okungapheli.
Umjovo we-Botox we-migraine yakho engapheli kuyindlela yokushesha, evame ukuhlala imizuzu engu-10 kuya kwemi-15, nezindawo eziningi ezungeze ikhanda nentamo zijojowe. Nakuba kungase kube nokuzwa okuncane okuvuthayo okuhambisana nomjovo ngamunye, ukunganaki kuphila isikhathi esifushane, futhi iningi labantu libekezelela kahle.
Ingabe i-Botox isebenza?
Isayensi ngemuva kweBotox ithembisa, nakuba kungenjalo ukuhlolwa komhlaba-ukuphazamisa-mhlaba kusikisela ukuthi incane ibe nomthelela omuhle.
Ucwaningo olulodwa lwezinhloko luhlolisise iziguli ezingaba ngu-1300 ezine-migraine engapheli kusukela ohlelweni lwe-PREEMPT. Uhlelo lwe-PREEMPT luhlolo lwesonto lomtholampilo lwamasonto angu-56 oluphenya ukusetshenziswa kwe-Onabotulinumtoxin A njengendlela yokwelashwa okungavamile yokuguquka kwamagraine.
Esifundweni se-PREEMPT, abahlanganyeli babenomsebenzi wokuthola ama-injection emisipha yekhanda nentamo ye-Onabotulinumtoxin A ngokumelene nomjovo we-placebo njalo amasonto angu-12 emijikelezweni engu-5 (inani lama-injection angu-31). Kulabo ababambiqhaza, amaphesenti angu-35 ayehlulekile izivivinyo ezintathu zokuvimbela imithi, kanti amaphesenti angu-65 ayehlulekile eyodwa.
Bonke baxilongwa nge-migraine engapheli. Abahlanganyeli kanye nama-injection ye-Botox babengaziboni ukwelashwa, okusho ukuthi abazi ukuthi yiziphi izijova abazitholayo (i-Botox ne-placebo).
Imiphumela yabonisa ukuthi labo abathola i-Onabotulinumtoxin A imijovo babengase banciphise inani lezinsizwa zabo ekupheleni kwesikhathi sokutadisha (amaviki angu-56). Babenemiphumela eminingi yokubika "amahora ekhanda" ngaphansi kwezinsuku ababephethe ikhanda.
Esifundweni esithile e -Journal of Headache and Pain , iziguli ezingu-254 ezine- migraine ezingapheli zazijojowe nge-Onabotulinumtoxin A eMtholampilo wase-Hill Migraine e-England. Amaphesenti angaphezu kwangu-90 alabo ababambiqhaza ayezame izifo ezintathu zokuvimbela imithi esikhathini esidlule futhi ahluleka ukuphendula. Bazithola ama-Botox injection ngendlela efanayo, njengoba lokho kufeziwe esifundweni se-PREEMPT. Ababambe iqhaza balondoloze idayari okungenani izinsuku ezingamashumi amathathu ngaphambi nangemva kokuthola imijovo.
Imiphumela yabonisa ukuthi i-OnabotulinumtoxinIzinsuku ezincane ezinciphise ikhanda nezinsuku ze-migraine okungenani ngamaphesenti angu-50, futhi zanda izinsuku ezingenasifo zamahhala kusukela kokuqala. Iphesenti yeziguli ezitholile okungenani amaphesenti angama-75 ekunciphiseni kwezinsuku zezinsizwa nezinsuku ze-migraine zaziyi-14 amaphesenti namaphesenti angu-24, ngokulandelana.
Ukusetshenziswa kwe-OnabotulinumtoxinUphinde kuholele ekukhuleni komkhiqizo womsebenzi.
Okokugcina, isifundo ku- JAMA , esasihlaziye kakhulu ekuhloleni okuningi okulawulwa ngokungahleliwe okuqhathaniswa ne-botulinum I-A nge-placebo, futhi kuphakanyiswe inzuzo encane ye-migraine-Botox. Kulokhu kuhlaziywa, ababambiqhaza bahlanganisa nalabo abanezinhlobonhlobo zezinsizwa ezifana: i-episodic migraine, ikhanda lokuhlukunyezwa kwengqondo engapheli, kanye nesifo sekhanda esingapheli.
Imiphumela iphakamise ukuthi i-Botox inenzuzo ekuvimbeleni i-migraine engapheli, kodwa hhayi ku-epradic migraine noma kumakhanda wezinkinga ezingavamile. Kubalulekile ukwazi ukuthi ukunciphisa ngokuphelele kwenani lezinsizi ngenyanga ngenyanga yalolu cwaningo litholakala ukuthi kunezinsuku ezimbili kuya kwezingu-3 - ezincane kakhulu, kodwa kubalulekile kwabaningi.
Kufana nokuba neviki elilodwa ngenyanga ngaphandle kwamakhanda.
Yiziphi i-Downsides ye-Botox ?:
Ngolunye, njenganoma yimiphi imithi, kukhona amandla okuba nemiphumela emibi. Esifundweni se- JAMA , le miphumela emibi ibonwe kubahlanganyeli abengeziwe ababhekene ne-Botox injection kunamaqembu we-placebo-okushiwo ukuthi asabalulekile, kodwa kufanelekile ukuphawula.
- Ubuthakathaka bemisipha
- I-blepharoptosis
- Ukuqina kwesikhumba
- Paresthesia
- Ukuqina kwentamo
- Ubuhlungu bemisipha
Ukuphathwa ikhanda nakho kungabangela ukujola kwe-Botox-okuyizinto eziphazamisayo-kodwa ungakhathazeki, lokhu kuvame ukuphila isikhathi esifushane.
Enye iphuzu ukuthi i-Botox ingaba yabiza kakhulu. Izinkampani eziningi zomshuwalense zidinga amadokhumenti amakhulu ukuthi uhlulekile ezinye izindlela zokuvimbela imithi ngaphambi kokumboza i-Botox, futhi ngezinye izikhathi, ngisho nalokhu akusebenzi.
Okubalulekile
Ukuphenywa okwengeziwe kwesayensi ku-Botox kuyoba usizo. Lokho kuthiwa, i-Botox ibonakala ihlinzeka ngenzuzo ethile ekuvikeleni imithi eqhamukayo. Kuhle ukuphawula ukuthi ungasebenzisa i-Botox kanye neminye imithi yakho ye-migraine-ngakho kungakunika ukukhululeka okungeziweko okungazange uthole imithi yakho yedwa.
Imithombo:
I-Aurora SK, i-Winner P, i-Freeman MC, i-Spierings EL, i-Heating JO, i-DeGryse RE et al. I-OnabotulinumtoxinA Ibhokisi lamathuluzi ekhanda lokukhanda : I-Botox-A yokuPhepha kwe- Migraine engapheli : Imibuzo evame ukubuzwa noma Ukwelashwa kwe-C engaqondakaliyo i-Migraine: Ukuhlaziywa okuhlanganisiwe kwe-56-week Week PreEMPT Clinical Program. Izinwele. 2011 Oct; 51 (9): 1358-73.
I-Jackson JL, i-Kuriyama A, i-Hayashino Y. Botulinum I-Toxin A ye-Prophylactic Ukwelashwa kwe-Migraine ne-Stroke Headaches kubantu abadalaUkuhlaziywa kwe-Meta. I-JAMA. 2012; 307 (16): 1736-1745.
U-Khalil M, Zafar HW, Quarshie V, Ahmed F. Ukuhlaziywa okubonakalayo kokusetshenziswa kwe-OnabotulinumtoxinA (BOTOX) ku-Treatment of Chronic Migraine; Idatha ye-Real-Life ku-254 Iziguli ezivela eHull, UK. I-J Headache Pain. 2014 Sep 1; 15: 54.
I-Rothrock, i-JS (2012). I-American Headache Society. Ibhokisi lamathuluzi ekhanda .