Izimo ezinhlobonhlobo zezikhumba ezihlukile, ezifaka i- eczema , i-urticaria ne-angioedema, ne-erythema multiform, zingalimaza ngesikhathi sokuqala. Uma lezi zimo ziba nzima kakhulu izinsuku ezintathu ukuya kwezingu-10 ngaphambi kokuqala kwama-mens, lo wesifazane angaba ne-auto-mune progesterone dermatitis (APD). I-APD nayo ikwazi ukuqhubekela phambili ku- anaphylaxis .
Enye indlela ye-anaphylaxis ehlobene nomjikelezo wokuya esikhathini i-anaphylaxis. Laba bobabili bakholelwa ukuthi yizimo ezingavamile.
Yenza ngokuzenzakalelayo i-Progesterone Dermatitis
Ukuzenzakalela i-progesterone dermatitis (i-APD) kwenzeka njengomphumela wokuziphikisa owenziwe ku- progesterone yowesifazane. Izimpawu zenzeka njalo kusuka ezinsukwini ezintathu ukuya kwezingu-10 ngaphambi kokuqala kwama-mens bese ziqala ukuxazulula zingakapheli izinsuku ezimbili kuya kwezinsuku emva kokuqala kokuya esikhathini. I-APD ingaba nezimpawu ezihlukahlukene, nakuba iningi, uma kungenjalo, lihlanganisa ukuhlukumeza isikhumba. Lokhu kufaka phakathi i-eczema, imihlathi, ukuqhuma kwezidakamizwa, i-erythema multiforme, i-angioedema, ngisho ne-anaphylaxis. Kungase kungabonakali ekuqaleni kowesifazane othintekile ukuthi izimpawu zakhe zibi kakhulu ngesikhathi sokuqala, futhi ngokuvamile kuthatha udokotela ukubuza umbuzo wokuba nezimo ezibuhlungu ezihlobene nomjikelezo wokuya esikhathini ngaphambi kokuba iphethini ibonakale kulowo wesifazane.
I-APD ingase ibangelwe ekuqaleni ngowesifazane ophethe amaphilisi okulawula ukubeletha noma elinye isongezo se-hormone equkethe i-progesterone eholela ekusondiseni i -hormone. Ukukhulelwa kungaholela ekukhuthazeni i-progesterone, futhi ukukhulelwa kungaba nemiphumela emihle esimisweni somzimba sokuzivikela futhi kungathinta kakhulu izimo ezihlukahlukene zokugula.
Abanye besifazane bangase bahlakulele i-APD ngenxa yokusebenza kabusha nge- corticosteroids , enezinhlaka ezifanayo zamangqamuzana kuma-hormone. Ngenkathi ukusabela kwamagciwane kunezinye i-hormone, njenge-estrogen, kungenzeka, lezi zivame kakhulu kunokuba zenzeke ku-progesterone.
Ukuxilongwa kwe-APD kudinga ukubonakaliswa kwamagciwane okulwa ne-IgE ngokumelene ne-progesterone, eyenziwa ngokuhlolwa kwesilwane . Ukuhlolwa kwesikhumba nge-progesterone kungenziwa yi-allergenists eminingi, engase ilandelwe yinselele yezidakamizwa ngokusebenzisa umjovo we-progesterone ngokuqapha okusheshayo kwezimpawu. Le nqubo kufanele yenziwe kuphela ngudokotela onolwazi ekuxilongweni nasekwelapha imithi ye-allergies ne-anaphylaxis, kunikezwa ukuthi kungenzeka ukuthi ukubhekana nokugula okuyingozi kungenzeka ngenxa yokuhlolwa.
Ukwelashwa kwe-APD kungaphumelela ngokusetshenziswa kwama- antihistamine kanye ne-corticosteroids yomlomo noma yejoyi, nakuba le mithi ingasiza kuphela ukuphatha izimpawu kunokulungisa le nkinga. Imithi evimbela ukuvuthwa, njenge-leuprolide, ivimbela ukuphakama kwe-progesterone ngesikhathi sokuya esikhathini futhi yizo zokwelashwa ezikhethwayo ze-APD. Ngokuvamile, ukususwa kokuhlinzwa kwama-ovari nesisu kudingekile ezimweni ezimbi ze-APD uma imithi ingakwazi ukulawula izimpawu.
Anaphylaxis enomzimba
I-anaphylaxis enesifo somzimba ingenye isimo esihlobene nomjikelezo wesimiso. Abesifazane abanalesi simo bahlangabezana nezimpawu ze-anaphylaxis ngokushesha ukuqala kokuya esikhathini futhi izimpawu ziyaqhubeka kuze kufike ukugeleza kwamanzi. Ngokungafani ne-APD, noma kunjalo, i-anaphylaxis enobungozi ayiyona into yokulimaza kodwa kunalokho ibangelwa yi- prostaglandins ekhishwe emgqeni wesibeletho (i-endometrium), engangena emzimbeni wegazi. Ukuxilongwa kuvame ukufakwa emtholampilo, njengoba ukuhlolwa kokungezwani komzimba ku-progesterone (namanye amahomoni) akubi. Ukwelashwa kwe-anaphylaxis enomzimba kuye kwaba yimpumelelo ngokusebenzisa imithi engeyona i-steroidal anti-inflammatory (NSAIDs ) , njenge-Indocin (indomethacin).
Ukususwa kokuhlinzwa kwama-ovaries kanye nesibindi kuyadingeka ezimweni ezinzima zokwelapha i-anaphylaxis uma imithi ingakwazi ukulawula izimpawu.
> Imithombo:
> Yenza i-Progesterone Dermatitis ngokuzenzakalelayo. Isikhungo Sokwaziswa Ngezifo Ezifuywayo Ne-Genetic and Rare Diseases Information. https://rarediseases.info.nih.gov/diseases/9139/autoimmune-progesterone-dermatitis.
> Bauer CS, Kampitak T, Messieh ML, Kelly KJ, Vadas P. Heterogeneity ekubonisweni nasekwelapheni i-anaphylaxis yokugula. Ama-Annal ofergy, i-Asthma & Immunology . 2013; 111 (2): 107-111. i-doi: 10.1016 / j.anai.2013.06.001.
> Nguyen T, Ahmed AR. Yenza ngokuzenzakalelayo i-progesterone dermatitis: Ukubuyekeza nokuqonda. Ukubuyekeza okuzenzakalelayo . 2016; 15 (2): 191-197. doi: 10.1016 / j.autrev.2015.11.003.