Ukukhuluphala kuye kwaxhunyaniswa nezifo eziningi, kuhlanganise nomdlavuza , isifo senhliziyo , nesifo sikashukela, phakathi kwabanye. Manje abacwaningi baxhumane ne-Alzheimer's disease.
Middle Age ne-Alzheimer's
Abacwaningi baye bathola ngokuqondile ukuthi ukukhuluphala phakathi kweminyaka yobudala, noma i-midlife, kubikezela ukuqala kokugula kwesifo se-Alzheimer- futhi umthwalo ophezulu wezifo (okusho ukuthi lesi sifo sizoba nzima kakhulu uma sihlasela).
Ekuhlaziyweni kweBaltimore Longitudinal Study of Aging, abacwaningi babheka ubuhlobo phakathi kwe-middlelife body index index (BMI) nesikhathi sokuqala kwesifo se-Alzheimer kanye nobuhlungu besifo. Ababhali bokutadisha bathola ukuthi i-BMI ephakeme eminyakeni yobudala (iminyaka engama-50 ubudala) yayihlotshaniswa nokuqala kokuqala kwesifo se-Alzheimer kanye nezinyathelo eziphakeme zokuqina kwesifo.
Abacwaningi bathola ukuthi kwakukhona ukudluliswa kwamagciwane amaningi (isici esichazayo se-Alzheimer's disease) ebuchosheni beziguli ezine-middle-life BMI, uma kuqhathaniswa nalabo abane-BMI enempilo eneminyaka engama-50. Lokhu kubonisa uhlobo olubi kakhulu lwesifo .
Abacwaningi baphetha ngokuthi i-BMI enempilo phakathi ne-midlife ingase ibambezele ukuqala kwesifo se-Alzheimer. Lokhu kuyakhuthaza, ngoba kusho ukuthi ukuthola i-BMI yakho ezingeni eliphilile phakathi ne-midlife kungaqeda ukuqala kwe-Alzheimer's. Futhi imisebenzi eminingi enempilo ehamba ngokulahlekelwa isisindo esiningi nokugcina isisindo esinempilo, njengokudla okulinganiselayo nokuzivocavoca umzimba, nazo ziyizinto ezigcina ubuchopho obuphephile futhi zisiza ekuvimbeleni ukucindezeleka kwengqondo ngaphakathi.
Ukukhuluphala nesifo senhliziyo
Ucwaningo lwangaphambili luye lwabonisa njalo ukuthi ukukhuluphala kuhlotshaniswa nomqondo we-dementia, futhi njengoba i-BMI iphakama, ngakho-ke izinga lokungcola. Kwesinye isifundo esifana nalokhu okushiwo ngenhla, kodwa esenziwa empumalanga ye-Finland, abacwaningi balandela iziguli iminyaka engu-26, balinganisa i-BMI yabo eneminyaka engama-50 ubudala futhi ngokuhamba kwesikhathi, baneminyaka engama-71 ubudala. Abacwaningi babecabanga ukuthi iziguli zathuthuka ukugula komqondo esikhathini esizayo empilweni, futhi zathola ukuthi, futhi, i-midlife ephakeme ye-BMI yayihlotshaniswa nengozi ephezulu yokugula kwesifo sengqondo kanye ne-Alzheimer's disease.
Ukuhlaziywa kwe-Swedish Twin Registry ngabacwaningi baphetha ngokuthi "kokubili ukukhuluphala ngokweqile nokukhuluphala phakathi kwe-midlife kukhululekile ukukhulisa ingozi yokugula komzimba [ne-Alzheimer's disease]."
Abanye bathole ukuthi isifo sikashukela, esiyisifo esithinta ukukhuluphala ngokweqile, singase siholele ekufikeni komqondo kwangaphambili. Ngakho kunezizathu eziningi zokugxila ekulahlekelweni kwesisindo esiningi ngendlela enempilo.
I-Stave Off Weight Weba Phakathi Kokuphakathi
Ubufakazi bubonakala bucacile ngalokhu: ukugqithisa ngokweqile nokukhuluphala phakathi kwe-middlelife kubeka engozini enkulu yokuthuthukisa u-dementia kanye nokuqala kwesifo se-Alzheimer. Ngeshwa, i-midlife nayo yisikhathi lapho abantu abaningi bevame ukuba nesisindo, njengoba umzimba wehlisa umzimba kancane futhi abaningi bahlala behlala phansi.
Ukukwazi lokhu, noma kunjalo, kufanele kuholele ekuqapheleni okukhulu phakathi kweminyaka yobudala ukuze uqhubeke nokuphila okusebenzayo futhi udle kahle. Kukhona, ngenhlanhla, izindlela eziningi zokwenza lokhu.
Ukudla okunomsoco okuhloswe ekugqugquzelweni kwempilo yengqondo kuyaziwa ngokuthi yi-MIND diet. Lokhu kudla kwadalwa iqembu labacwaningi abanikeze igama elide le " M Mgwaqo waseMediterranean-Indlela Yokudla Ye-Systolic Hypertension (DASH) yokunciphisa inqubo yokuthola amaphuzu okudla okuyi-Eurodegenerative d elay (MIND)." Umlomo, uqiniseke! Ngakho-ke kwaziwa ngokumane nje njengokudla kwe-MIND.
Leli phuzu lithatha izingxenye zombili kokudla kwaseMedithera kanye nokudla kwe-DASH okuye kwaboniswa ukuthi iyisivikelo ekubhekaneni nokuncipha kwengqondo nokugula kwesifo se-Alzheimer. Futhi, njengalezo zokudla, ukudla kwe-MIND kuye kwatholakala ekucwaningweni kocwaningo ukuncipha kwengqondo kancane; kunganciphisa ingozi ye-Alzheimer's disease.
Lokhu kubonisa ukuthi lokho okudlayo kunendaba ngempela. Ukuze ulandele ukudla kwe-MIND, udinga ukuqaphela amaqembu okudla angu-15, okuyishumi kuwo okubhekwa njengamaqembu "okudla okunomqondo ophephile," kanti amahlanu awo angamaqembu okudla okumele agweme.
Imithombo
I-Chuang YF, i-Y, uBilgel M, et al. I-Midlife i-adpodicity ibikezela ukuqala kokudemeka kwengqondo, i-neuropathology ne-presymptomatic cerebral amyloid. Mol Psychiatry 2015 Sep 1. [Epub ngaphambi kokuphrinta]
Isifo sikashukela phakathi ne-midlife singase siphuthumise ukucindezeleka esikhathini esizayo. I-Harv Health Lett 2015; 40: 8.
> Morris MC, Tangney CC, Wang Y, Sacks FM, et al. Ukudla okunomsoco kuhlotshaniswa nesifo esincane se-Alzheimer's disease. I-Alzheimer Dement 2015; 11: 1007-14.
I-Tolpannen AM, Ngandu T, Kareholt I, et al. I-Midlife kanye ne-late-life body mass index kanye nokuphelelwa yisikhathi kwengqondo yokuphila komzimba: imiphumela evela eqenjini elibhekene nendawo labantu.
I-Whitmer RA, i-Gunderson EP, i-Quesenberry CP Jr, et al. Inkomba yezimpawu zomzimba phakathi kwe-middlelife kanye nengozi ye-Alzheimer's disease kanye nokucindezeleka kwengqondo. I-Curr Alzheimer Res 2007; 4: 103-9.
Xu WL, Atti AR, Gatz M, Pedersen NL, et al. I-Midlife ngokweqile kanye nokukhuluphala ngokweqile kwandisa ingozi yokudemeka kwengqondo ekupheleni kwesikhathi: isifundo se-twin-based based population. I-Neurology 2011; 76: 1568-74.