Izidakamizwa zenzelwe ukuphula futhi zikhiphe i-mucus ku-COPD
Esinye sezici ezisemqoka zesifo esingenasifo se-pulmonary chronic obstructive (COPD) yi-production excess of mucus emaphashini. Lokhu kukhishwa ngokweqile, ngezinye izikhathi okubhekwa njenge-mucus hypersecretion engapheli, kubangelwa ukuvuvukala isikhathi eside okwandisa kokubili inombolo nenani lalawo okuthiwa "amangqamuzana e-goblet" afaka izingxenye zomoya.
Ngenkathi amangqamuzana egobolondo evame ukumisa i-mucus njengendlela yokuvikelwa, ne-COPD ukukhiqizwa ngokweqile kungavala amavesi, okwenza kube nzima ukuphefumula.
Enye indlela yokususa lesi sakhi sinomuthi okhuluma ngomlomo noma ongathandabuzwayo obizwa nge-mucolytic. I-Mucolytics isebenza ngokuqeda izibopho zamakhemikhali ngaphakathi kwemfihlo, ephule ukuze bakwazi ukukhukhulwa kalula.
Ngesikhathi ama-mucolytics engabhekwa njengengxenye yesimiso samanje sokunakekela ukwelashwa kwe- COPD , imihlahlandlela ka-2017 ekhishwe yi-Global Initiative Yokuvimbela Izifo Zokuvimbela Izifo (GOLD) iphakamisa ukuthi ingaba usizo kubantu abangatholi i- corticosteroids engatholakali .
Sibutsetelo seMucolytic Drugs ekuphatheni i-COPD
I-Mucolytics ingathathwa ngomlomo kuthebhulethi noma isiraphu ukubunjwa noma inhaled nge nebulizer . Ezinye zezinhlobo ezivame ukusetshenziswa ezisetshenziswa ku-COPD zihlanganisa:
- I-Carbocysteine
- N-acetylcysteine
- U-Erdosteine
- Mecysteine
- Guaifenesin
- I-Bromhexine
Indlela yokusebenza ingahluka ngezidakamizwa. Ngokwesibonelo, i-Carbocysteine yenza izenzo zokuvimbela amangqamuzana e-goblet futhi inikeza nezinzuzo zokulwa ne-antioxidant kanye ne-anti-inflammatory.
I-N-acetylcysteine, ngokuphambene nalokho, iphula izibopho ezibamba ubumbano ndawonye ngenkathi zishintsha ukungalingani kwamakhemikhali nama-antioxidants.
Imiphumela emibi ingahlukahluka kokubili ngohlobo lwezidakamizwa nokubunjwa. Ngokusobala, ukucwenga kanye nokuhuda kuyindlela ejwayelekile kakhulu ehlangene namaphilisi, kanti izimpawu zamanzi zingase zibangele ukuphazamiseka kwamagciwane nokuhlukumeza.
Ukubunjwa okungafani nakho kungabangela ubuhlungu obukhulu, impumu egijimayo, nokwakhiwa kwamakhanda amhlophe emlonyeni noma ezindebeni.
Ngokuvamile, ama-mucolytics abhekwa njengophephile futhi ahlotshaniswa nengozi ephansi yezenzakalo ezimbi kubantu abane-COPD. Uma kuthiwa, kubalulekile njalo ukukhuluma nodokotela wakho nganoma yikuphi ukulimala, ukusebenzisana, noma ukuphikisana okuhambisana nomkhiqizo owenzela umkhiqizo, kungakhathaliseki ukuthi kunqunywe noma kuthengwe phezu kwekhawuntini.
Ukusebenza kwe-Mucolytics ku-COPD
Naphezu kokusetshenziswa kwezidakamizwa ze-mucoactive ku-COPD, ubufakazi bamanje abusekeli kakhulu ukusebenza kwabo.
Ukubuyekezwa kuka-2015 kwezilingo ezingu-34 kwaphetha ngokuthi labo abathatha ama-mucolytics babengenakudlula amathuba okubhekana nokucindezeleka kwe- COPD . Ekuhlaziyeni imiphumela, lokhu kuholele ekunciphiseni okuncane kakhulu kweminye iminyaka emithathu. Ezinye izifundo zithole ezinye iziphetho ezifanayo.
Noma kunjalo, naphezu kwalezi ziphutha, abanye baye bathi ama-mucolytics anendawo ekunakekeleni kwe-COPD. Njengoba kunikezwe ukukhathazeka mayelana nokuphepha kokusetshenziswa kwesikhathi eside kwe-corticosteroid , kube khona iziphakamiso ezingaba zifanelekile ku-COPD ephakeme lapho ingozi yokukhuphuka iphezulu ngaphandle kokusetshenziswa kwe-steroid.
I-Mucolytics, kulezi zimo, ingasiza ekunciphiseni inani lezinkathazo futhi unikeze ezinye ngcono izinga lokuphila.
Omunye u-substudy ohlotshaniswa neBronchitis Okuhleliwe kwi-NAC Cost-Utility Study (BRONCUS) wabuye waphetha ngokuthi, uma isetshenziswe nge-corticosteroid engatholakali, izidakamizwa ezingasetshenziswanga zinganciphisa ukukhushulwa kwe-COPD ngamaphesenti angama-21.
I-Mucolytics ingase ibe usizo nakakhulu kubantu abangenakubekezelelana kwe-corticosteroids engatholakali noma abanenkinga nge-inhalers ephathekayo.
Imithombo:
> I-Global Initiative ye-Lung Dungase Chronicle Obstructive. (2017) Umhlahlandlela wePocket ku-COPD Ukuxilongwa, Ukuphathwa, Nokuvimbela: Umhlahlandlela Wezokwelapha Zomsebenzi Wezempilo (Umbiko we-2017) .
> Loukides, S .; I-Bakakos, i-P .; ne-Kostikas, K. "I-Mucolytics ku-COPD: Njengewayini elibomvu?" I- PNEUMON. 2013; 4 (26): 1-4.
> Poole, P .; I-Chong, J .; kanye noCates, J. "Ama-Mucolytic ehambisana ne-placebo ye-bronchitis engapheli noma isifo esingavamile se-pulmonary." Cochrane Database Syst Rev. 2015; 29: 7: CD001287.