Indlela Isikhumba Sakho Nesimiso Sakho Sokuzivikela Ngaphandle Sisebenza Ngani Ukuze Uhlale Unempilo
Amangqamuzana e-Langerhans (LCs) atholakala esikhumbeni (i- epidermis ne- dermis ) yokuphefumula, ukugaya ukudla kanye namapheshana e-urogenital. Zingatholakala nakwezinye izicubu ezinjenge-lymph nodes, ikakhulu uma isimo seLangerhans cell histiocytosis (LCH) sibandakanyeka.
I-LCs ikusiza ukukuvikela ngokugcina ama-antigens ayingozi (noma yikuphi okubangela ukuthi isimiso somzimba samasosha omzimba senze ama-antibodies ngokumelene nalo) ukungena emzimbeni wakho.
I-Langerhans Amaseli Asebenza Kanjani
Kutholakale umfundi wezokwelapha waseJalimane oneminyaka engu-21, uPaul Langerhans, ngo-1868, amangqamuzana aseLangerhans akhona kuzo zonke izingxenye ze-epidermis futhi angamalungu omndeni we-dendritic. Amangqamuzana e-Dendritic amasosha omzimba anika ama-antigens kumzimba wokuzivikela futhi atholakala kuwo wonke umzimba. Ama-LC amangama-dendritic esikhumbeni futhi kusukela amangqamuzana e-dendritic asebenza kahle kakhulu ekuvikeleni amasosha omzimba ekufikeni kwamagciwane kanye nezinye izinto zakwamanye amazwe, isikhumba siyimbangela ebalulekile ekutheleleni.
Ama-LC aqale ecatshangwa ukuthi ayengxenye yesimiso sezinzwa futhi aqaphele kuphela isimiso somzimba sokuvikela omzimba kuma-antigen. Esikhundleni salokho, ucwaningo lithole ukuthi i-LC yanciphisa ukusabela kwesikhumba ekutheleleni kanye nokuvuvukala ngezindlela ezimbili ezihlukene kakhulu:
- Ngokuvikela isikhumba sakho kusuka ekutheleleni.
- Ngokugqugquzela ukusabela kwe-allergenic.
Amangqamuzana e-Langerhans athumela ama-agent akhethekile-amangqamuzana omzimba omzimba njengama-T namaseli B-ngokushesha ngemva kokubona noma yiluphi uhlobo lengozi esikhumbeni.
Amasosha omzimba asithatha abaphambuka njengabaktheriya namagciwane futhi balwe nokulimala njengokusikeka nokwehla.
Imvelo yesikhumba ihlale ihlolwe yi-LCs ngezimo ezingaphephile futhi amasosha omzimba athunyelwa ukubuyisela ulwazi mayelana nanoma yiziphi izimbangi zangaphandle. Umzimba bese uhlanganisa amandla amakhulu amangqamuzana okuvuvukala ukulwa nabahlaseli ngokudala ukusabela noma ukudala izicubu ezibomvu ukuvikela kusuka ekutheleleni.
Izimo ze-LC nezesikhumba
Ucwaningo olusha luveza ukuthi amangqamuzana e-Langerhans akwazi ukubona nokuhlasela amagciwane avela kumvelo ozungezile, ngaleyo ndlela avimbele ukutheleleka. Ukuthola ukuthi ama-LC ahilelekile ekuphenduleni izifo zokuzivikela ngokumelene nezifo ezihlukahlukene kungabenza kube nezinhloso ezikhona zokuzivikela nge- immunotherapy .
Lokhu okutholakele nakho kunakho ukuguqula kakhulu ukuqonda izindlela ezithinta izifo eziningi zesikhumba ezifana nalezi:
- I-Psoriasis : Isimo lapho amangqamuzana ekhanda akha khona futhi ayenze izikali ezihambisana nokubomvu, ukuhlambalaza nama-patche owomile.
- I-Lupus : Isifo esibangela ukuvuvukala esibangelwa ukuthi amasosha omzimba ahlasela izicubu zakhe.
- Umdlavuza wesikhumba : Ifomu elijwayelekile kakhulu le-Cancer e-US, elibhekiselwe ukukhula okungavamile kwamangqamuzana esikhumba.
Kungase kube khona ukuthuthukiswa kwemigomo ye-topical ephethwe ngesikhumba (ukugoma okwe-Epicutaneous) okugxila ekulayisheni i-LCs ngqo esikhumbeni nama-antigens. Ukucwaninga kakade kubheka imishanguzo enikezwe isikhumba esiphazamisekile ukuze kuvimbele ukukhula kwe- melanoma , uhlobo olunzulu lomdlavuza wesikhumba.
Iyini i-Langerhans Cell Histiocytosis (LCH)?
I-Langerhans cell hertiocytosis (LCH) iqoqo lezinkinga ezingavamile, idiopathic ezingalimaza isikhumba, amathambo nezinye izitho.
I-overload of cells efana ne-LCs ikhiqizwa kule nkinga, noma kunjalo, amangqamuzana e-LCH abonisa i-hematopoietic (i-blood cell) eyimvelaphi ye-disorder.
Imithombo:
Langerhans P. Über die Nerven der menschlichen Haut. I-Virchows Arch [A] 1868; 44: 325-337.
Seo N., et al. I-percutaneous peptide immunization nge-corneum-barrier-iphazamise isikhumba somugudu wokuhlola i-tumor immunoprophylaxis. Proc Natl Acad Sci USA 2000; 97: 371-376.
Yagi H., et al . Ukwehliswa kwamathambo e-cytotoxic T e-human by the peptide vaccine. I-Cancer Res 2006; 66: 10136-10144.