I-MTHFR Gene ne-TRPV1 Gene esekela ku-Migraines
Uma uhlushwa ukukhubazeka kwemigraines, kunethuba elihle lokuthi udadewabo, umzala wakho, noma umama wakho wenza kanjalo. Lokhu kungenxa yokuthi izakhi zakho zofuzo zenza ube lula kakhulu ekuthuthukiseni i-migraines.
Ake sihlole i-genetics ye-migraines nokuthi lokhu kusho ukuthini wena nomndeni wakho.
Ukusebenzisana Phakathi Kwezakhi Zofuzo Ne-Environment ku-Headaches
Iningi lezinsizwa liwumphumela wezici eziningi zezakhi zofuzo nezemvelo ezisebenzisanayo kuwebhu enzima.
Nakuba abaningi benu basebenza ngokungazelelwe ekulawuleni izimo zemvelo ngokugwema ukugwema nokuguqulwa kokuziphatha, ngokusobala awukwazi ukushintsha izakhi zofuzo owazalwa nazo. Kodwa-ke, ngokutadisha izakhi zofuzo ezihilelekile ekuthomeni kwe-migraine, ososayensi bangadala izidakamizwa ezintsha ezibhekene nezakhi zofuzo ezithile, ngamathemba okuphulukisa, uma kungenzi ukunciphisa ikhanda lethu elinzima futhi elilimazayo.
Yiziphi izinhlobo zeGenesis ezibandakanya eMigraines?
Kunendima ebalulekile yefa ekuthuthukisweni kwe-migraines nezinye izinhloko eziyinhloko . Lokhu kuboniswe ngemibuthano eminingi yomndeni namawele amabili. Kodwa yiziphi izakhi zofuzo zangempela ezidluliswayo? Ngaphansi kwalesi sibonelo sezakhi zofuzo ezimbili ezicatshangelwe ukuthi zidlala indima ekubunjweni kwe-migraines.
Esinye isakhi sofuzo sibizwa ngokuthi i- MTHFR gene , esho isikhathi eside, i-methylenetetrahydrofolate reductase. Leli gciwane lihileleke endleleni ye-homocysteine. I-homocysteine i-amino acid egazini lethu lapho liphakanyisiwe, lingabangela ukuthumba kwegazi, kanye nokudubula kwamangqamuzana athile omzimba angase abandakanyeke emakhanda.
Izinguquko ezithile kule ge gene ziye zahlotshaniswa kokubili imithi ye-migraines ne- cluster headaches .
Ucwaningo olulodwa ku- Pharmacogenetics naseGenomics lwathola ukuthi kwabesifazane abane- migraine abanama-aura , isisombululo se-vitamin esinciphisa kakhulu amazinga abo ase-homocysteine, ama-migraine obunzima, namazinga okukhubazeka kwe-migraine, uma kuqhathaniswa nabesifazane abathatha indawo ye-placebo.
I-vitamin B6, B9 (folic acid), ne-B12, etholakala emazingeni aphansi e-homocysteine egazini.
Ngaphezu kwalokho, lapho iqembu elibhekwa ne-vitamin lihlolwe ngokucophelela, litholakala ukuthi iziguli ezine-allele ethile yegciwane le-MTHFR zanciphisa kakhulu amazinga e-homocysteine, kanye nokuhlukunyezwa kwe-migraine nokukhubazeka, kunezinkinga ezihlukile . I-allele yindlela ehlukile yesigenja esinezindawo ezithile kwi-chromosome ethile. Lokhu kutholakala kubonisa ukuthi izinhlobo ezithile zezakhi zofuzo zingathonya indlela abahamba phambili abahamba ngayo bephendula nge-vitamin supplementation.
I-TRPV1 (Uhlobo oluthile oluhlobene nolwazi olunokwenzeka lwe-Vanilloid Uhlobo 1) luhlongozwa ukuba lube nendima ebalulekile ekuqinisekiseni i-migraine - igama elibhekisela kwisistimu yezinzwa ezibucayi noma ezisebenzayo ezigulini ezinemigraines.
Leli gciwane lidlala indima ekudambiseni i-hyperalgesia ne- allodynia , izimo ezimbili ezingenzeka ngesikhathi sokuhlasela kwe-migraine. I-hyperalgesia ibhekisela ekuphenduleni okwandisiwe ekuvuseleleni okubuhlungu. I-Allodynia ibhekisela ekuphenduleni okubuhlungu ekuvuseleleni okungavamile okungenabungozi, njengokuzizwa kabi ngokuthinta okulula phakathi nokuhlasela kwe-migraine.
Eminyakeni embalwa eyedlule, izidakamizwa ezibhekiswe eziteshini ze-TRP ziye zacutshungulwa njengezindlela zokwelashwa ezingase zibe khona.
Esinye isibonelo somuthi ohlose isiteshi se-TRPV1 ngu- sumatriptan , ukwelashwa okuvamile kwe-migraine.
Lokho Kusho Ngami?
Isithombe esikhulu lapha ukuthi i-migraines inezakhi zofuzo eziqinile. Ngokufunda kabanzi mayelana nezakhi zofuzo ezithatha isandulela esisodwa kuya ku-migraines, ososayensi bangakwazi ukukhomba izidakamizwa kulezi zakhi zofuzo.
Futhi, ukuqonda izakhi zofuzo ze-migraine kungase kunciphise abanye umthwalo womthwalo wabantu, njengoba bezama ukulawula ukuhlasela kwabo kwe-migraine. Cabangela ukuxoxa ngomlando wakho womndeni nomhlinzeki wakho wezempilo, njengoba lokhu kungase kuhlinzeke ngokuqondisisa ngemigraines yakho futhi kuthinte ukwelapha esizayo.
Imithombo:
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Izindlela JE, Neeb L, Reuter U. TRPV1 ku-migraine pathophysiology. Amathrendi e-Mol Med. 2010; 14 (4): 153-159.
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