Abavimbela i-Beta basebenzisa okuningi kwezokwelapha. Esinye esibaluleke kakhulu ukwelashwa kweziguli ezine- artery disease (CAD) kanye ne-angina.
I-Beta Blockers Izuza Njani Iziguli Ezibhekene Ne-Angina?
Ezigulini ezine- angina ezinzile ezibangelwa i-CAD, i-beta blockers ibhekwa njengokwelashwa kokuqala komugqa.
Ngama-angina azinzile, eyodwa noma ngaphezulu ye-coronary arteries ivinjiwe kancane nge- plaque atherosclerotic .
Ngokuvamile, imisipha yenhliziyo ehlinzekwa yi-artery enezifo ithola ukugeleza kwegazi okwanele ngesikhathi sokuphumula. Kodwa ngesikhathi sokuzivocavoca noma izikhathi zokucindezeleka, ukuvinjelwa okuyingxenye kuvimbela ukugeleza kwegazi kungakhulumi ngokwanele ukunikeza oksijini okudingekayo emzimbeni wenhliziyo esebenzayo, futhi imisipha iba ischemic (ilambile oksijini). Ngenxa yalokho, angina kwenzeka.
Abavimba be-Beta basebenza ngokuvimbela umphumela we-adrenaline enhliziyweni. Lokhu kunemiphumela emibili enkulu enhle kwiziguli ezine-angina:
- Ukunciphisa izinga lokushaya kwenhliziyo, ikakhulukazi ngezikhathi zokuzivocavoca noma ukucindezeleka.
- Ukunciphisa amandla e-muscle contraction.
Zombili lezi zimphumela zinciphisa inani le-oksijini edingekayo ngenxa yesisindo senhliziyo, futhi i-ischemia (ne-angina) iphuzile noma ivinjelwe ngenxa yalokho.
Iyini Impumelelo Yabaqaphi Beta Ezigulini Zine-Angina?
Kuziguli ezine-angina, i-beta blockers ngokuvamile iphumelela kakhulu ekuthuthukiseni amandla noma isikhathi sokuzivocavoca okungenziwa ngaphandle kokuthuthukisa ischemia noma angina.
Iziguli ezine-angina ezinzile ezithatha i-beta blockers zivame ukwehla okubonakalayo kweziqephu ze-angina futhi kufanele zithathe i-nitroglycerin kaningi.
Ngaphezu kwalokho, kuziguli ezine-angina ezine- infarction ye-myocardial . (ukuhlaselwa kwenhliziyo), i-beta blockers yizo kuphela izidakamizwa ezilwa no-angina eziye zaboniswa ukunciphisa ingozi yokuba nelinye i-infarction ye-myocardial.
Ngaphezu kwalokho, kwabasindile be-infarction ye-myocardial, noma ezigulini ezinokuhluleka kwenhliziyo ngaphezu kwe-angina eqinile, i-beta blockers kuye kwaboniswa ukuthi kuthuthukiswe ngokuphawulekayo ukusinda jikelele.
Izinzuzo ezinikezwa yi-beta blockers zenze zaba izidakamizwa zokukhetha kuqala ekuphatheni iziguli ezine-CAD kanye nama-angina azinzile.
Imiphumela emibi yeBet Blockers
Imiphumela emibi kakhulu ye-beta blockers ihlanganisa i-bradycardia (izinga lentliziyo elincane), ubunzima bokuphefumula kubantu abane-asthma noma isifo samaphaphu esingapheli, ukukhathala, ukuwohloka kwezibonakaliso zesifo se- arterial , ukucindezeleka, nokungasebenzi kahle kwe-erectile . Abavimbela i-Beta kufanele futhi bagwenywe ngeziguli ezine-angina ngenxa ye-angina ye-Prinzmetal (i-coronary artery spasm) , ngoba kulezi ziguli ze-beta blockers zingase zidale isikhala esiningi.
Eziningi zala miphumela emibi zingagwenywa ezigulini ezine-angina ngokusebenzisa i-beta blockers esebenza ngokuyinhloko enhliziyweni ngokwayo, futhi enomthelela omncane emithanjeni yegazi, emaphashini nasesimweni esiyinhloko sezinzwa. Lezi "cardioselective" beta blockers yi-Tenormin (atenolol) ne-metoprolol (Lopressor, Toprol XL).
> Umthombo:
> Fihn SD, Gardin JM, Abrams J, et al. Umhlahlandlela we-ACCF / AHA / ACP / AATS / PCNA / SCAI / STS we-Diagnosis and Management of Iziguli ezine-Stable Ischemic Heart Disease: Umbiko we-American College of Cardiology Foundation / i-American Heart Association Task Force on Guidelines Practice, kanye I-American College of Physicians, i-American Association ye-Thoracic Surgery, i-Prevention of Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, kanye neNhlangano Yezifo Ezihlinzeka Ngama-Thoracic. Ukujikeleza ngo-2012; 126: e354.