Ubufakazi Bendima Ekukhulekeleni Okungapheli Okukhathala
I-Epstein-Barr virus (EBV) ilungu lomndeni we-herpesvirus kanye neyodwa yamagciwane omuntu avamile. Sekuyisikhathi eside ixhunyaniswe ngentshiseko ku- syndrome engapheliyo ( ME / CFS ), nabanye abacwaningi bathi kuyimbangela ebalulekile ye-causal kanti abanye bathi akubandakanyi nalesi sifo nhlobo.
Labo abakholelwa ukuthi kuxhunyiwe kuvame ukukhuluma ngokuvuselelwa kabusha.
Zonke i-herpesviruses zihlala ohlelweni lwakho kuze kube phakade, kepha ngokuvamile zihlala zihlala isikhathi eside. Uma beba abakhuthele, amaseli akhethekile emasimini omzimba, kuhlanganise nama- B namaseli kanye nama- T-cell , ngokuvamile ayinayo inkinga yokubambaza futhi.
Abantu abaningi abazi ngisho nokuthi le nqubo iyaqhubeka. Kungenxa yokuthi ama-B-ne-T-cell, esimisweni somzimba sokuzivikela esinempilo, khumbula igciwane futhi angakwazi ukuhlangana masinyane ibutho lama-antibodies ukuze alihlole.
Uma amasosha omzimba engasebenzi kahle, noma kunjalo, kungase kuthiwe ukuthi igciwane lizuze emazingeni aphinde akwenze ugule. Uma lokho kwenzeka, kubizwa ngokuthi ukuvuselelwa.
Ubufakazi bokubuyiselwa kabusha
Sinebufakazi obuningi bokusekela i-typothesis yokuvuselelwa kwe-EBV kwezinye izimo ze-ME / CFS. Ukucwaningwa okwenziwe ngo-2014 kugudluza lelo cwaningo.
Kulolu cwaningo, ososayensi bathola ubufakazi bokuthi ama-B-no-T-cells abantu abaningi abanalesi sifo abakwazanga ukukhumbula i-EBV, okusho ukuthi igciwane elivuselelwe lizokwazi kangcono ukukhula, ukukhiqiza nokudala izimpawu.
Abacwaningi bathole lokhu okukhunjulwa kwememori yeselula kuma-immune systems amaphesenti angu-76 angaphezu kuka-400 ababambiqhaza. Lona iphesenti elihlaba umxhwele.
Ngokuhambisana nokubonisa ukuthi yini engabangela futhi igcine ezinye izimo ze-ME / CFS, abacwaningi bathi lo msebenzi ungadlulisela kumakaki wokuhlola okufunwa isikhathi eside. (Okwamanje, asikho ukuhlolwa komgomo wokuthola i-ME / CFS , ngakho-ke ihlala ixilongwa ngokukhipha.)
Okuningi mayelana ne-Virus Epstein-Barr
I-EBV yisigciwane esibi. Kuyaziwa kakhulu ngokubangela i- mononucleosis esithathelwanayo, evame ukubizwa ngokuthi i-mono noma "isifo sokubanga." Izimpawu ze-mono zihlanganisa:
- Ukukhathala okukhulu
- Umphimbo obuhlungu
- Izinwele
- Fever
- Ama-muscle aches
- Ukuvuvukala kwama-lymph nodes
- Ukuzwela ukukhanya
- Ukuphelelwa umoya
Ukubuyiselwa okuvela ku- mono kuyaziwa ukuthatha isikhathi eside, futhi ukuphindaphinda kubonakala ngokukhathala okukhulu.
Abanye abacwaningi sekuyisikhathi eside bakholelwa ukuthi akuyona into emangalisa ukuthi lezi ziyizimpawu ze-ME / CFS. Noma kunjalo, ingxenye enkulu yabantu ithwala i-EBV emizimbeni yabo futhi inani elincane lalabo bantu lithuthukisa i-ME / CFS. Lokhu kuye kwaphazamisa imizamo yokuchaza ukuthi i-EBV ingafaka kanjani ekuguleni.
Lolu cwaningo lubonakala lunqobe leyo nkinga, noma kunjalo, ukunikeza impendulo yalo mbuzo. Awuphenduli imibuzo mayelana nokuthi kungani amanye amasosha omzimba omuntu abonakala engaboni ngaleli gciwane, noma kunjalo. Lesi yisihloko socwaningo oluzayo, njengoba sithola indlela yokulungisa ubuphofu.
Izifundo ze-EBV zangaphambilini
Okunye ukuhlola kubonise ukuthi inani elibalulekile lamantombazane angama-ME / CFS amasha maduze emagqumeni e-mono, futhi intsha eningi abadokotela abayibona engaziwa emasimeni ifanelana ne-ME / CFS yokuhlola.
Kubonakala sengathi i-EBV ehlukumezayo, cishe kungenzeka ukuthi ibangele ukugula isikhathi eside. (Funda kabanzi mayelana nalezi zitholakala ku-Cort Johnson e-Health Rising.)
Ngaphandle kwe-mono, i-EBV ihlotshaniswa nezinhlobo ezithile zomdlavuza, okungahlathulula izigameko eziphezulu zokugula nokufa okuhlobene nomdlavuza abanye ochwepheshe be-ME / CFS ababika ukuthi bawubonile. I-EBV ingase idale indima e- multiple sclerosis . Olunye ucwaningo lubonisa ukuthi lungalingisa i- leukemia elula.
Nokho, akukho okukodwa okuyiqiniso, kodwa. Sisekhona indlela ende yokuhamba uma kuziwa ku-EBV noma noma yiliphi igciwane njengesizathu esiyinhloko se-ME / CFS.
Izwi elivela
Ngalokhu kutholakala okusha kwememori yeselula, singase sigcwalise igebe elibalulekile kolwazi mayelana nokuthi i-EBV ingahle ibangele kanjani i-ME / CFS futhi inikeze izimpawu eziqhubekayo.
Ngenkathi kunomsebenzi odingekayo ukuze kuqinisekiswe lolu cwaningo, kungabangela odokotela abaningi ukuba banikeze imithi elwa namagciwane (njenge-valacyclovir noma i-valganciclovir) yeziguli ze-ME / CFS ezinezinga eliphezulu le-EBV.
> Imithombo:
> Chhabra P, uMthetho AD, Sharma U, et al. I-Epstein-barr virus ukutheleleka okuqhamuka njenge-leukemia enamandla: umbiko wamacala amabili nokubuyekezwa kwezincwadi. Umagazini we-Indian we-hematology nokumpompela igazi. 2014 Mar; 30 (1): 26-8.
> Loebel M, Strohschein K, Giannini C, et al. I-EBV eqondene ne-B-kanye ne-T-cell ephendulayo ngeziguli ezine-syndrome ezingapheli. PLoS One. 2014 Jan 15; 9 (1): e85387. eCollection 2014.