Ukunyakaza kwamehlo okuphuthumayo ukulala nokukhubazeka kokuziphatha kanye ne-melatonin
I-REM (ukunyakaza kwamehlo okusheshayo) ukuphazamiseka kokuziphatha kokulala kungacasula uma kungenayo ingozi futhi bekuphazamise ukwelashwa. Yini esiyifunde ngendima ye-supplemental melatonin ekwelapheni lezi zinkinga?
REM Behavior Disorders (RBD)
Kungenzeka ukuthi awuzange uzwe mayelana nezinkinga zokuziphatha kwe-REM (RBDs) , kodwa abantu abaningi bajwayele izibonelo ezithile ezivamile.
Uma wazi ngomuntu ophupha ngokuhlaselwa ngumuntu noma isilwane futhi evukile ukushaya umyeni wakhe, uzwile isibonelo. Uma wena noma omunye umuntu owaziyo uye waphumelela ngenxa yamaphupho akho (ngenkathi eselele), kungenzeka kube isimo esaziwa njenge-RBD.
Ukulala ne-RBD
Ngesikhathi sobusuku obujwayelekile bokulala, sihamba ngezigaba ezahlukene zokulala. Ukulala kwe-REM (ne-REM ehlelwe ukulala ngokushesha kwe-eye ukulala) ubuchopho busebenza kakhulu. Yisigaba sokulala esivame ukuhambisana namaphupho. Ngesikhathi sibhekene nokulala kwe-REM ngokuvamile asikwazi ukusebenzisa imisipha yethu, ngaphandle kwemisipha yamehlo futhi impela imfucuza yethu (ngakho-ke siyaqhubeka siphefumula). Uma ezinye izinhlanzi zethu zingapheli amandla ngale ndlela yokulala, singase sibe namandla okwenza amaphupho ethu. Lezi zenzo zibhekwa njengezinkinga zokuziphatha kwe-REM.
Abantu abaningi babhekana nokulala kwe-REM nxazonke njalo ngamaminithi angu-90. Ekuqaleni kokulala kobusuku lezi zikhathi zifushane kodwa ziqhubeka isikhathi eside njengoba sisondela ekuvuseni ekuseni.
Ukulala okungenani kwe-REM kwenzeka engxenyeni yesithathu yokulala ebusuku.
I-REM evamile Yokulala Disorder Izithako
Ngeshwa, amaphupho amaningi ahlobene neRBD ayamnandi futhi ahlanganisa ukungena noma ukuhlaselwa kwefomu elithile. Uma la maphupho ahunyushwa ezenzweni, ukuziphatha kungabandakanya ukujezisa, ukukhahlela, ukuwela embhede, ukukhuluma noma ukukhala.
Uma lezi zenzo zenzeka zingabangela ukulimala kumuntu ohlangabezana no-RBD noma abalingani bombhede wabo. I-RBD ithinta abantu abangaba ngu-1 kubantu abangu-200 futhi ivame kakhulu emadodeni amadala aphakathi, iye yahlotshaniswa nesifo sikaPasinson nezinye izimo zezinzwa, kanye nokuhoxisa utshwala, kanti futhi kungenzeka kube impendulo engafanele emithini efana ne-anti-depressants. Kubuye kubonwe kubantu abasha abanezinkinga zokuhlukumezeka .
I-RBD ingaba yingozi. Kwesinye isifundo, amaphesenti angama-32 kuya kwangu-64 abantu abahlukunyezwa yi-RBD babangela ukulimala kwabo noma umlingani wabo wombhede. Ezingamaphesenti angu-7 lokhu kuhilelekile ithambo eliphukile. Ngokungajwayelekile, i-RBD ibangele ukulimala noma ukulimala kwengqondo ebuhlungu. Nakuba ukulimala kanzima, ngaphandle kwe-RBD ngaphandle kokulimala kungabangela ukucindezeleka okukhulu kokubili othintekayo kanye nomlingani wabo wombhede.
I-Melatonin ne-Sleep
I-Melatonin iyi-hormone engokwemvelo etholakala ngaphezu kwe-counter. Sekusetshenziselwa kakhulu ukusetshenziselwa ukwelapha izidakamizwa zomsindo we-circadian , izinkinga zokulala ezingaziwa, i-jet lag, nezibonakaliso ze-menopausal. Kuye kwacwaningwa ngomphumela walo kulesi sifo sika-Alzheimer's , ngisho nangenxa yokukwazi ukuvimbela nokuphatha umdlavuza .
I-Melatonin ikhiqizwa ngokwemvelo enkingeni ye-pineal yobuchopho ngesikhathi sokulala. Amazinga amakhulu afihliwe ebumnyameni futhi yilesi sizathu esivela kuncoma yokulala egumbini elimnyama nezibani zivaliwe. Ngaphezu kokukhanya ebusuku, ukugula nobudala bunganciphisa inani lemvelo elifihliwe. Ukwehliswa kwe-Melatonin kuqala kusihlwa futhi kuphakama phakathi kobusuku (phakathi kuka-2 no-4 ekuseni.)
Ingabe i-melatonin inendima engalindelekile ekwelapheni ukukhubazeka kwe-REM (RBD) ?
Ukusebenza kwe-Melatonin ye-REM Sleep Behavior Disorders
I-Melatonin iye yacwaningwa ngendima yayo ekuphatheni i-RBD, futhi eqinisweni, manje kunconywa umugqa wokuqala (ngaphambi kwanoma yini enye) yokwelashwa kwalesi sifo sokulala.
Kubonakala sengathi kunomthelela oqondile ngokwengeziwe kulesi sifo kune-Klonopin (clonazepam), ukwelashwa kokuqala kokunconywa ngaphambili. Akukona kuphela ukuthi i-melatonin isebenza kangcono, iphephile futhi ibekezeleleke ngaphezu kweKlonopin.
Ezicwaningweni, i-melatonin yanciphisa ithoni ye-muscle ngesikhathi sokulala kwe-REM (abantu bathuthele kancane phakathi nalesi sigaba sokulala) okusho ukunciphisa ikhono lokwenza amaphupho. Lokhu kubonakala ezifundweni ezitholile ukuthi i-melatonin yehlisa ngokucacile ukuziphatha kwe-REM.
Inothi ukuthi ama-melatonin asetshenziselwa ukuphatha i-RBD avame ukuphakama kunalawo asetshenziselwa usizo lokulala, kanye nama-3 mg kuya ku-12 mg asetshenziselwa izifundo eziphawuliwe.
Izithako ze-Melatonin nazo zibonakala ziphumelele kubantu abane- Parkinson's disease , i-Lewy yomqondo wengqondo yomzimba, kanye ne- multiple system atrophy -imiqathango evame ukuhlangana ne-RBD.
Kungenzeka kanjani ukuthi i-Melatonin isebenze ukuphatha i-RBD ne-Sleep Disorders?
Naphezu kokusebenza kwayo ekunciphiseni ukukhubazeka kokuziphatha kwe-REM, asikwazi ngokuphelele ukuthi i-melatonin isebenza kanjani. I-Melatonin ibonakala iyisignali emizimbeni yethu eqondisa ukulala kwethu nokuvuka emaphethini okukhanya nokunyama emvelweni wethu.
I-Melatonin ingasiza ukuvumelanisa amaphethini okulala ukukhuthaza ukulala. Kubonakala futhi ukuthuthukisa ukusebenza kokulala. Ezingeni elingama-molecular, ukuvimbela kwe-GABAergic (ukuvimbela omunye wezinzwa ze-neurotransmitters ebuchosheni) kungase kudlale indima.
Izinzuzo zikaMelatonin
Enye yezinzuzo ezinkulu zokusetshenziswa kwe-melatonin ukuthi inezinto ezimbalwa ezimbi. Uma kuqhathaniswa ne-Klonopin, i-melatonin inemiphumela emibi embalwa. Kubuye kube lula ukuxhumana neminye imithi umuntu ethatha.
Ukungahleleki nemiphumela emibi ye-Melatonin
Njengoba kuphawuliwe ekuqaleni, ukulinganisa kwe-melatonin esetshenziselwa ukuhlola ukuhlola ukusetshenziswa kwazo ezinkingeni zokuziphatha kwe-REM sekuphakeme kunelabo asetshenziselwa ukuleleka noma ukujula. Imiphumela emibi ejwayelekile etholakalayo kulezi zilinganiso kufakiwe ukulala ekuseni (amaphesenti angu-29), ukukhathazeka ukucabanga (amaphesenti angu-12), izinkinga zokulinganisela (amaphesenti angu-8), isisulu sokuhlukunyezwa (amaphesenti angu-8) nokukhubazeka ngokobulili (amaphesenti angu-8).
Ngezansi kokusetshenziswa kwe-Melatonin ye-REM Sleep Behavior Disorders
I-Melatonin ibonakala iyindlela evikelekile futhi ebekezeleleka kakhulu yokwelashwa kwezimo zokuziphatha kwe-REM kune-Klonopin, nakuba i-Klonopin iboniswe kahle ukuthi iyasebenza. I-Melatonin ibuye ibonakale isebenza kangcono, futhi cishe ifika ekumpandeni kokungajwayelekile kunokuba nje ilawule izimpawu. Abantu abaningi abathintekayo abane-RBD baneminyaka yobudala engama-50 nangaphezulu, ngezinye izimo zezokwelapha, futhi i-melatonin ayinakwenzeka kakhulu ukuxhumana neminye imithi kune-Klonopin. Ngokuvamile, ukusetshenziswa kwe-melatonin kunikeza izindlela eziphumelelayo nezindlela eziphephile zokwelapha ngokuphathelene nenkinga yokunyakaza okusheshayo kokunyakaza kwamehlo okulala ukulala.
> Imithombo:
> Howell, M., noCenk. I-Rapid Eye Movement Sleep Sleeping Disorder. UpToDate . Kubuyekezwe 07/24/17.
> McGrane, I., Leung, J., St Louis, E., no B. Boeve. Ukwelapha kwe-Melatonin ye-REM Sleep Behavior Disorder: Ukubuyekezwa Okubalulekile Kobufakazi. Imithi yokulala . 2015. 16 (1): 19-26.