Imithi yokwelapha yokugcina imithi
Imisipha ye-Migraine ingakwazi ukushaya nganoma isiphi isikhathi, futhi ukuwaphatha kungase kungabi lula ngaso sonke isikhathi, ngakho kungase kube usizo ukufunda okwengeziwe mayelana nokuvimbela i-migraine. Uma uhlushwa yi- migraines ejwayelekile , umhlinzeki wakho wokunakekelwa kwezempilo angancoma ukwelashwa okuvimbela kunokuba uthole izindlela zokwelapha ezilula. Imithi emine yokugunyazwa kwe-FDA evumelekile isetshenziselwa ukuvimbela i-migraine, kodwa ezinye izinketho ezingasebenza futhi.
Imithi Evunyelwe i-FDA
Ukulawulwa Kwezokudla Nezidakamizwa kuvumile imithi emine ye- migraine prevention , noma i-prophylaxis. Ziyi-propranolol (Inderal), i-timolol (i-Blocadren), i-topiramate (i-Topamax) ne-divalproex sodium (i- Depakote ). Lezi zibhekwa njengezokwelapha "lokuqala" ku-migraine prophylaxis. Kunezikhathi lapho ungase ungakwazi khona ukubekezelela ngenxa yemiphumela emibi noma ngoba enye yezokwelapha zokuqala ayiphumeli. Uma lokhu kwenzeka, umhlinzeki wakho wezempilo angabeka omunye umuthi ongasiza. Lokhu kubizwa ngokusebenzisa imithi "off-ilebula." Lokhu kuvamile futhi kungaba isisombululo kangcono kuwe.
Beta-Blockers
Ama-beta-blockers imithi ngokuvamile esetshenziselwa ukwelapha umfutho wegazi ophakeme ( umfutho wegazi ophezulu ), kodwa kukhona nezinye izinsiza eziningi. I-Propranolol ne-timolol bobabili be-beta-blockers. Ezinye ezingase zivivinywe ekwelapheni kwemithi zihlanganisa i-atenolol (i-Tenormin), i-metoprolol ende (i-Toprol XL) noma i-nadolol (Corgard).
Imiphumela emibi evamile ihlanganisa ukukhathala, isicanucanu, isizungu, ukuleleka nokucindezeleka. Ukungahambisani nokusetshenziswa kwazo kuhlanganisa i- hypoglycemia ehambisana nesifo sikashukela, i- hypotension , i-asthma noma ezinye izimo zenhliziyo.
Ama-antidepressants
I-Amitriptyline i-anti-depressant eyaziwa ngokuthi i-tricyclic antidepressant (TCA). Nakuba kungenjalo i-FDA-evunyelwe ukuvimbela i-migraine, kuye kwaba nezifundo eziningi ezibonisa ukuthi i-amitriptyline ingaba yimithi ephumelelayo ye-prophylactic.
Kubonakala sengathi isebenza ngokukhethekile uma une-migraine ethatha izinhlobo ezahlukene noma unezici ezivamile ezinhlokweni zekhanda. I-Amitriptyline nayo ingasebenza uma abathintekayo be-migraine benesifo sokuqwashisa noma ukucindezeleka okuhambisana nekhanda. Imiphumela emibi evamile ihlanganisa ukulala, ukuzuza isisindo, nomlomo owomile.
I-Selective Serotonin Reuptake Inhibitors (i-SSRIs), njenge-fluoxetine (i-Prozac), isetshenziswa ngezikhathi ezithile ekuvimbeleni kwe-migraine, kodwa ucwaningo alusekeli ukusetshenziswa kwabo okubanzi.
Anticonvulsants
Ama-anticonvulsants kukhona imithi ekuqaleni okuhloswe ukuphatha ukuthunjwa kwesibindi. Zinezinye izinto ezisetshenziswayo, kuhlanganise nokuvimbela ikhanda lekhanda le-migraine. I-Divalproex (i-Depakote) ivunyiwe yi-FDA, futhi izifundo eziningi zisekela ukusetshenziswa kwayo. Imiphumela emibi yezinsizi ivamile kodwa iyancipha njengoba isikhathi sidlula. Iziguli ezikhulelwe kanye nalabo abanesifo sesibindi noma umlando we-pancreatitis akufanele zisetshenziswe nhlobo.
I-Topiramate (i-Topamax) enye i-anticonvulsant ebonakala iyisinqumo esihle sokuvimbela i-migraine. Imiphumela emibi ejwayelekile ifaka ukukhathala nokucabangela, nakuba imithi encane ayibanga izinkinga eziningi.
Ezinye Izinketho
Kuneminye imithi eminingi esetshenziselwa ukuvimbela imithi ye-migraines, ayikho enye eyayivunyelwe i-FDA kuleli phuzu.
I-Lisinopril (i-Zestril), i-ACE-inhibitor esetshenziselwa ukwelapha umfutho wegazi ophezulu, uye wabonisa isithembiso esithile sokuvimbela ama-migraines. I-Candesartan (i-Atacand) iyi-blocker ye-angiotensin receptor (ARB) ukuthi, ngokwesinye isifundo, ingase iphumelele ku-migraine prophylaxis.
Ama-blockers wesiteshi se-calcium yimishanguzo yengcindezi yegazi eye yasetshenziselwa ngokomlando ukuvimbela i-migraine. Kukhona ubufakazi obuncane besayensi obusekelwe ekusebenzeni kwawo, nakuba kukhona ubufakazi obuthakathaka obonisa ukuthi i-verapamil (iCalan) ingaba usizo.
Ukusetshenziswa kwezidakamizwa ezingapheliyo zokuvimbela izidakamizwa (NSAID) kungaba yingozi ngenxa yezinkinga zomzimba ezingabangela, kodwa kunezinye izimo lapho ama-NSAID angase abe usizo ekuvikeleni imigraines, ikakhulukazi naproxen (Naprosyn).
Ukuthatha ama-NSAID ngaphambi nangesikhathi sokuya esikhathini kungase kube usizo ekuvimbeleni ukuhamba esikhathini sokuya esikhathini .
Imithombo:
Izidakamizwa ze-migraine. Imihlahlandlela yokwelashwa evela kwi- The Medical Letter , 2004; 2: 63-66.
I-Migraine. I-National Headache Foundation. Ibuyiselwe: December 9, 2008. http://www.headaches.org/education/Headache_Topic_Sheets/Migraine
I-Modi S, i-Lowder DM. Imithi ye-migraine prophylaxis. Am Fam Physician . 2006 no-Nov 15; 74 (10): 1685. Ibuyiselwe: December 9, 2008. http://www.aafp.org/afp/20060101/72.html
I-Tronvik E, i-Stovner LJ, i-Helde G, i-Sand T, i-Bovim G. ukwelashwa kwe-prophylactic ye-migraine ne-angiotensin II receptor blocker: isilingo esilawulwa ngokungahleliwe. I-JAMA , 2003; 289: 65-9.