Wake wake wazibuza ukuthi ngabe kukhona yini umehluko phakathi kokudemeka komzimba nezidumbu zaseLeby kanye nesifo sengqondo se-Parkinson? Uma uke wezwa izimpawu zalezi zifo ezimbili, zizwakala ngokumangalisa ngokufanayo. Kungenxa yokuthi bobabili izinhlobo ze-Lewy yomqondo wengqondo yomzimba.
Lewy Body Dementia
Kunezinhlobo ezimbili ze-Lewy yomqondo wengqondo yomzimba: ukucindezeleka komzimba ngezidumbu ze-Lewy (DLB) kanye nokugula komqondo ka-Parkinson (PDD).
Izimpawu ezabelwana ngazo ze-PDD ne-DLB
Ukuze uqonde umehluko phakathi kwe-PDD ne-DLB, kubalulekile ukuqonda ukuthi kunezigaba ezimbili zezimpawu ezenzeka kokubili i-PDD ne-DLB.
- Umzimba : Izimpawu ezithinta umzimba zihlanganisa ubuthakathaka obuthakathaka, ukuqina (ukuqina) nokuhamba kancane ekuhambeni.
- Ubuchopho : Izimpawu ezibonakala ebuchosheni zibandakanya ukusebenza okusebenzayo okungaziphathi kahle, isikhathi sokuqapha, nokulahleka kwememori.
Zombili lezi zinhlobo zokudemeka kwengqondo zinempawu ezithinta umzimba nobuchopho. Ama-hallucinations nokucindezeleka kuvame ukuvela kuzo zombili izinhlobo zokudemuka kwengqondo, futhi. Zombili lezi zimo zivame ukuphathwa ngemithi ebizwa ngokuthi i- carinsopa-levodopa (Sinemet) , okungaba usizo ngokuthuthukisa ikhono lokuhamba nokusebenza ngokomzimba, kanye nokwehlisa imithi yokuvimbela inhibitor , enganciphisa ukuncipha kwengqondo .
Umehluko Phakathi kuka-PDD no-DLB
Ngakho-ke, i-PDD ne-DLB ihluke kanjani komunye nomunye?
Lokho kuxhomeke kubani oyicelayo. Abanye odokotela babenomuzwa wokuthi lezi zimo ezimbili ziyizinguqulo ezihlukile zesifo esifanayo. Eqinisweni, ngiye ngazwa ngisho nabanye ochwepheshe basebenzise la magama ngokungafani. Noma kunjalo, ngokuvumelana nemikhombandlela yokuxilonga okwamanje evumelwaneni, kukhona ukungafani.
Umehluko omkhulu phakathi kwe-Parkinson's dementia nesifo sengqondo somzimba nge-Lewy imizimba yindlela yokuqala kwezimpawu.
Abahlengikazi bavame ukuhlukanisa phakathi kwalokhu ngokubuza ukuthi yiziphi izimpawu (umzimba noma ubuchopho) ovele kuqala.
Ukuze kutholakale ukugula komqondo kaParkinson, izimpawu zokuhamba nokuhamba, kufaka phakathi ukuqina, ubuthakathaka nokuthuthumela, kufanele kube khona okungenani ngonyaka owodwa ngaphambi kokuncipha kwengqondo.
I-dementia enezidumbu ze-Lewy itholakala ukuthi ngabe izimpawu zokuhamba nokuqina komzimba zenzeke ngesikhathi esifanayo njengokuncipha kwengqondo, uma izimpawu zokuqaphela zenzeka ngaphambi kwezimpawu zemoto, noma uma ukwehla kwengqondo kungakapheli unyaka owodwa ngemuva kokuba izimpawu zemoto ziqale.
Zikhona Ukunye Ukungafani?
Ukuhluka ku- Cognition
Abantu abanesifo sengqondo se-dementia nezidumbu zaseLewy bavame ukukhombisa ukuhlukahluka okukhulu ekuhlakanipheni kunabo abanesifo sengqondo se-Parkinson. Lokhu kubalulekile ukuqonda ngoba amalungu omndeni nabanakekeli bangase bakhungatheke ngenye indlela futhi bakholelwe ukuthi lowo muntu ukhetha isikhathi (noma ngisho nokuphazamisa) ukukhubazeka kwakhe okucatshangelwayo.
Ukuqonda ukuguquguquka okungenzeka kwamakhono engqondo kubalulekile ekuhlolweni nasekuhloleni kwengqondo. Abantu abane-dementia yesifo se-Parkinson bangenza okufanayo ekuhlolweni kokucubungula ngisho noma ubahlola ngezikhathi ezahlukene zosuku noma ngezinsuku ezahlukene.
Kodwa-ke, umuntu onesifo sengqondo sokugula komzimba nge-Lewy izidumbu angabonisa imemori ethuthukile noma ukuhlushwa ngezikhathi ezithile futhi ngokuphawulekayo ukucindezeleka okubi nakwezinye izikhathi. Ngakho-ke, kubalulekile ukuqhuba ukuhlolwa kwengqondo izikhathi ezingaphezu kwesisodwa ukuze uhlole ngokunembile umuntu onokugula komzimba nge-bodyy Lewy.
Izindlela Zokulala
I-DLB ivame ukuthinta ubuthongo ngokuphawulekayo ngoba ukungalali kahle kwe-REM, isimo lapho abantu benza khona amaphupho abo njengoba belele, kuvame kakhulu ezinyathelweni zakuqala ze-DLB uma kuqhathaniswa ne-PDD. Lokhu ngokuvamile kuyisimangaliso sokuqala kwe-Lewy ukugula komzimba.
Izimbangela ze-PDD ne-DLB
Zombili izinhlobo zengqondo ye-dementia zibhekene nokutholakala kwezidumbu zaseLewy ebuchosheni, i- atrophy yamaseli obuchopho nezinkinga ze-acetylcholine zokudlulisela.
Zombili izinhlobo zengqondo ye-dementia (nakuba lokhu kungase zivame kakhulu ku-DLB) zingabuye zibe neprotheni ethile ye- amyloid beta ebuchosheni futhi, okuyisici esisodwa se- Alzheimer's disease .
Imithombo:
I-Deutsches Arzteblatt International. 2010 Okthoba; 107 (39): 684-691. I-Lewy Body kanye ne-Parkinsonian Dementia. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957617/
I-Lewy Body Dementia Association. Izinhlobo ze-Lewy Body Dementia. http://lbda.org/content/lbd-booklet/types-of-lbd
I-Neurology. Umqulu 68 (11), 13 Mashi 2007, iphe. 812-819. Izinkinga zomngcele we-DLB ne-PDD: Ukuxilongwa, ukwelashwa, izifo ze-molecular and biomarkers. http://www.neurology.org/content/68/11/812.abstract?sid=be7f0348-f70f-4b92-b56f-e09ba641b396
I-Parkinson's Disease Society yase-United Kingdom. I-Q & A: I-Dementia ne-Parkinson. http://www.parkinsons.org.uk/content/qa-dementia-and-parkinsons