Imithi yemithi yokwelapha yokuvimbela i-Orexin ku-Brain
I-pharmaceutical drug suvorexant-ithengiswa ngaphansi kwegama leBelsomra-iyilitha elilodwa eliyingqayizivele yokuleleka kwegciwane elisetshenziselwa ukuphatha inkinga yokuwa noma ukulala ubumnyama obunzima. Funda ukuthi isebenza kanjani neminye imiphumela emibi kanye nezingozi ezihlobene nokusetshenziswa kwe-Belsomra.
Ukusetshenziswa kwe-Belsomra
I-Belsomra imithi yokwelashwa eyenza ebuchosheni ukunciphisa ukuvuka nokuthuthukisa ubuthongo.
Kubangela ukulala futhi kuphumelele ekuqaliseni nasekulondolozeni ubuthongo. Isetshenziswa ngokuyinhloko ukuphatha ukungalali. Kubonakala sengathi kunezinzuzo ezithobekile kubantu abaningi abacwaningayo abonisa ukuthi abadoti balala ngokushesha ngamaminithi angu-6 futhi balele imizuzu engu-16 kuphela, uma kuqhathaniswa ne-placebo.
I-Belsomra Isebenza Kanjani Ukuphatha Ukushona?
I-Belsomra ihlukile phakathi kwamaphilisi okulala ngendlela esebenza ngayo. Kuvunywe yi-US Food Administration and Drug Administration ngo-2014, yilapho eqala ekilasini lemithi eyenziwa njengabaphikisi be- orexin . I-Orexin yi-neurotransmitter, noma isithunywa samakhemikhali, ngaphakathi kwengqondo ekhuthaza ukuvuka. Uma kuvinjelwe, njengoba kwenzeka nabamelene, ukulala kungabangela.
I-Belsomra ikhetha kakhulu ama-receptors wesignali okuthiwa i-OX1R no-OX2R ngaphakathi kobuchopho. Ngokuhlanganyela nalezi zitholampilo, iyakwazi ukuvimbela izinto ezithuthukiswayo ezibizwa nge-orexin A ne-orexin B, okuyiyona eyehlisa ikhono lokuhlala liphapheme.
Izimpawu ze-narcolepsy zenzeka ngenxa yokulahlekelwa unomphela kwala maseli ane-orexin.
Ubani Akufanele Asebenzise Belsomra?
Kukhona abantu abathile abangeke basebenzise i-Belsomra noma okufanele bayisebenzise ngokuqapha. Akufanele isetshenziswe uma unezinkinga zokuhlukunyezwa . Kumele kuthathwe kungakapheli imizuzu engu-30 yokulala futhi akufanele isetshenziswe uma ungakwazi ukunikela amahora angaphezulu kuka-7 ukuze ulale.
Ukuqapha okunye kukwaziswa uma unomlando wokucindezeleka, ukugula kwengqondo, noma imicabango yokuzibulala. Akufanele isetshenziswe ngokuhambisana notshwala noma ezinye izidakamizwa ezivimbela isimiso sezinzwa esiyinhloko noma uhlelo lokuphefumula. Uma unomlando wokusebenzisa kabi izidakamizwa noma ukubheja ngokweqile, akufanele uyisebenzise.
Labo abanezinkinga zamaphaphu noma isibindi kufanele baqaphe ekusebenziseni. Abantu abakhulu nabesifazane bangadinga amanani amancane ukuvimbela imiphumela emibi. Ngenxa yokuntula kolwazi mayelana nokulimala okungase kube khona, akukhuthazwa ukuthi kusetshenziswe abesifazane abakhulelwe noma abancancisayo.
Yiziphi Imiphumela Ezingavamile Noma Ezimbi ZeBelsomra?
Kunemiphumela emibi eminingi engase ibe yimuphi umuthi. Umphumela ovame kakhulu we-Belsomra ukulala. Ngisho noma kungenzeka ukuthi umuntu angeke abe nemiphumela emibi kakhulu ehambisana nalesi sidakamizwa - futhi kungenzeka ukuthi ayinakho - enye engenzeka ngeBelsomra ihlanganisa:
- Ukugungqa, ukuzamazama, noma umuzwa "wezidakamizwa"
- Ukuqapha nokungasebenzi kahle, kufaka phakathi ingozi yokushayela ukulala
- Ukucabanga okungavamile nokuguquka kokuziphatha (ukuphuma okuphumayo noma okuhlukumezayo, ukudideka, ukukhathazeka, ukulahlekelwa inkumbulo, ukukhathazeka, nokucabangela )
- Ukucindezeleka okukhulu nokucabanga okuzibulala
- Ukuziphatha okuhambisana nokulala okuhambisana nokulala (ukushayela, ukudla, ukulala, njll)
- Ukugula ukukhubazeka (ukungakwazi ukuhamba ngesikhathi sokulala)
- Ububuthakathaka besikhashana besimanje (okufana ne- cataplexy ngaphandle kwe-trigger)
- Ukuphefumula okuxubile
Yikuphi Ukuqapha Ukuphepha Okudingeka Ukuthathwe Nge-Belsomra?
Ngenxa yengozi engaziwa, i-Belsomra kufanele igwenywe ekukhulelwe nasekunceliseni. Abantu abathile, njengoba kushiwo ngenhla, kufanele basebenzise imithi ngokuqapha noma cha. Akukho ukuqapha okudingekayo ekusetshenzisweni kukaBelsomra.
Uma uhlangabezana nanoma yikuphi ubunzima, kufanele uxhumane eduze nomhlinzeki wakho wezempilo oyinhloko.
> Imithombo:
> "Ulwazi lwe-Belsomra oluPhelela ngokugcwele." Merck & Co., Inc. 2014.
> "Iwebhusayithi Esemthethweni YeBelsomra." Merck & Co., Inc. 2014.
> "I-FDA ivumela uhlobo olusha lwesidakamizwa sokulala, iBelsomra." Ukuphathwa Kwezokudla Nezidakamizwa zase-US . Agasti 13, 2014.