Ingabe ama-Probiotics angathuthukisa i-Asthma?

Ama-bacterium amahle angase abe mqoka ekuvimbeleni i-Asthma

Ngenkathi umthelela we-probiotics nge-asthma akucaci, ukukhishwa kwalesi sigaba semithi yokuvimbela nokwelashwa kwesifo sofuba kuyinto. Ukuphathwa kwemvelo, ukuphila ezincane ezinemizimba emibi kakhulu engabanikeza umphumela wezempilo onenzuzo ngesifo ngemiphumela ekhulayo kwisiguli kanye nomphakathi kuthanda kakhulu iziguli.

Ngenkathi kube nezifundo ezincane ezibonisa izinzuzo zokwelapha nge-probiotics nge-asthma lapho lezi zifundo zihlanganiswa ngenqubo yokubuyekezwa okuhleliwe nokuhlaziywa kwe-meta inzuzo jikelele ayizange ibonwe.

Ngokuvamile, ama-probiotics akakwazi ukuphakanyiswa okwamanje noma ukuvimbela noma ukwelashwa kwesifuba se-asthma.

Kuyini amaProbiotics

Ama-probiotics aphilayo aphilayo ama-microorganisms (ngokuvamile avame amabhaktheriya) ongayithatha ukuze abe nethonya elihle ku-asthma yakho noma unciphise ingozi yokuthuthukisa i-asthma . Zivame ukubizwa ngokuthi "amabhaktheriya anobungane" noma "amabhaktheriya amahle." Ezokwelapha ngokuvamile zisetshenziselwa ukuvimbela noma ukwelapha isifo sohudo esibangelwa ama-antibiotics. Ziye zasetshenziselwa izimo zempilo eziningana kuhlanganise nesifo sofuba esiswini, i-atopic dermatitis (eczema), i-rhinitis ye-allergen (i-hay fever), i-colic, ne-cold common.

I-probiotics yayiwumkhiqizo wezempilo wemvelo osetshenziselwa kakhulu emphakathini wesihlanu, kodwa ukusebenzisa abantu abadala kuncane kakhulu ngokuya ngo-2007 National Health Interview Survey.

Kungenzeka kanjani ukuthi amaProbiotics angasiza i-Asthma

I-microflora hypothesis iphakamisa ukuthi izinguquko amabhaktheriya zithinta ukuthuthukiswa kwesifo sofuba nesifo sofuba.

Ukucubungula amabhaktheriya kucatshangwa ukuthi kusize amasosha omzimba athuthukise futhi ukuphazanyiswa kuhlelo kuphazamise isifo sofuba. Eqinisweni, izinguquko ekuguleni amabhaktheriya zandulela ukuthuthukiswa kwe-dermatitis ye-atopic futhi zibonwa ukuthi yisinyathelo sokuqala ekuthuthukiseni izimpawu zokugula. Ukusetshenziswa ngokweqile kwama-antibiotics kunciphise amanani okuncelisa, futhi izinguquko ekudleni ziye zaholela ekushintsheni emagodini ezincane futhi kungenzeka ukwanda kwesifo sofuba.

Ngenkathi kunzima ukufakazela, ukuhlolwa kwezilwane kubonise ukuthi ukuphathwa kwezidakamizwa kuye kwaholela emoyeni we-air-responsive.

Ucwaningo oluthile luye lwabonisa ukuthi ukuphathwa kweLactobacillus rhamnosus neLacbabacillus fermentum noma ngesikhathi sokukhulelwa noma ngokushesha ngemva kokuzalwa kuholela ekuhlaleni kwesifo se-asthma nezinye izifo ezithathelwanayo. Kodwa-ke, izifundo eziningi ziye zahluleka ukubonisa inzuzo efanayo.

Abacwaningi abacwaningayo abathintekayo babheka izingane ezinamazinga ahlukahlukene okubeka ingozi ngesifo se-asthma esekelwe ezintweni ezihlukahlukene. Bese babheka "poo" noma isitokisi sabo sokuba khona kwamabhaktheriya. Abaphenyi babheka ukungezwani kwamabhaktheriya atholakala kumaqembu ahlukene emingciphekweni. Bathola ukuthi phakathi kwabantwana ababenamasondo futhi banesifo somzimba behlisa izinga lamaFaecalibacterium, iLachnospira, iRothia ne-Veillonella amabhaktheriya atholakale esitokisini uma kuqhathaniswa neqembu elinengozi ephansi kakhulu yokugubha kanye nokunciphisa umzimba. Leli qembu lalingase libheke kakhulu ukuthi lingeneminyaka engu-3 ubudala. Ukungafani kokuqukethwe kwesitembu kwabonakala kuphela ezinyangeni ezimbalwa zokuqala zokuphila. Lokhu kutholwe ukuthi abaphenyi bacindezele ukuthi izinguquko ekuqukethwe kwamagciwane ezinyangeni ezimbalwa zokuqala zokuphila zingathinta ingozi ye-asthma.

Baqhubeka bephakamisa ukuthi kungenzeka ukuthi kuthuthukiswe i-cocktail yebhaktheriya enganikezwa empilweni yokuqala ukuze kunciphise ingozi ye-asthma.

Abacwaningi bezilwane ezithakazelisayo zondla ama-bacteria amahhala mahhala noma isampuli esisezingeni elivela kwengane esengozini enkulu yokuphefumula, noma isampula enezinga eliphezulu le-Faecalibacterium, i-Lachnospira, i-Rothia ne-Veillonella amabhaktheriya. Izilwane zavunyelwa ukuba zizalwe futhi abaphenyi bazama ukwenza izinja zamantombazane zine-asthma. Amagundane anamabhaktheriya angeziwe ayenokuvuvukala okuncane emaphashini uma kuqhathaniswa namagundane angazange athole amabhaktheriya angeziwe.

Ngenkathi kuhlolwa okuthakazelisayo, izifundo zezilwane aziguquli njalo ezifundweni zabantu, ngakho-ke sicela ungabuyi ucele udokotela wakho kwisiguli sesitokisi.

Ama-probiotics ngokuyinhloko abathinta i-asthma ngokusebenzisa ingxenye yayo elwa nokuvuvukala.

Noma kunjalo, wonke ama-probiotics awafani ngokufanayo futhi angeke akhiqize umphumela ofanayo. Ngenxa yokuthi uhlobo oluthile lwe-probiotic lusiza nge-asthma, lokho akusho ukuthi olunye uhlobo lwe-probiotic luyoba nemiphumela efanayo noma efanayo. Ngokufanayo, umehluko ungabonakala nge-probiotic efanayo, kodwa yenziwe inkampani ehlukile. Ngenxa yalokho uma uthole iseluleko esivela kuchwepheshe wezezempilo mayelana ne-probiotic, mhlawumbe kudingeka uthole igama lesikhangiso segama. Uma ufunda ngesifundo sokucwaninga indlela kuphela ongase uzuze ngayo umphumela ofanayo ukusebenzisa i-probiotic ekhonjwe kusihloko sokucwaninga.

Izivivinyo Zomtholampilo Ngokusetshenziswa Kwe-Probiotic Emiphumeleni Ye-Asthma

Emilingo engu-4 yokuhlolwa kwama-probiotics ekwelapheni kwe-asthma, imiphumela eminingi ibike. Ucwaningo olulodwa lubonise izinyathelo ezingenasifo ezengeziwe, kanti enye ibonise isidingo sokunciphisa isidingo se-cromolyn sodium. Ucwaningo olulodwa lubonise ukuthuthukiswa kokuphakama kwenani nokusetshenziswa kwama-probiotics.

Ezinye imiphumela yomtholampilo ayizange ithuthukise futhi ihlanganise izinga lokuphila, isibalo sezibalo ze-asthma, ukusetshenziswa kwezilawuli noma imithi yokusiza. I-FEV1 ayizange ibonise umehluko omkhulu kwiziguli ezithola ama-probiotics uma kuqhathaniswa nalabo abathola indawo yokuhlala.

Ingabe ama-Probiotics aphephile

Ngaphandle kwegesi efana nezimpawu, iziguli zibonakala zithola imiphumela emibi kakhulu futhi zibekezelela ama-probiotics. Kodwa-ke, kukhona idatha encane etholakalayo ekusetshenzisweni kwesikhathi eside kwama-probiotics noma ukuhlanganiswa kwama-probiotics anezinye izindlela zokwelashwa. Kube khona imibiko yezinkinga ezinkulu uma unesimiso sokuzivikela somzimba esincane noma enye inkinga yezempilo ngakho kubalulekile ukuxoxa nodokotela wakho ngaphambi kokuqala ukwelashwa.

Nakuba akuyona inkinga yokuphepha yangempela, ama-probiotics awalawulwa njengoba kubhekwa njengengxenye yokufaka. Ngenxa yalokhu, azikho nemithetho eqinile elawula inqubo yokukhiqiza. Ngenxa yalokho, amanye ama-probiotics atholakale aqukethe izinkinga ezingabhalwanga kule ilebula kanye namanani amancane okuphila okuphilayo kunalokho okushiwo.

Kubalulekile ukuqaphela ukuthi eziningi zale mikhiqizo azilawulwa yi-FDA ngendlela efanayo nemithi yakho ejwayelekile ye-asthma. I-FDA ihlola izithasiselo zemiphumela emibi, kodwa njengoba ingavunyelwe njengezidakamizwa ezingabhekwa ngokufanayo. I-probiotics ayithwali izinkomba ze-asthma njengoba imithi yakho yenza. Le mikhiqizo ngeke ifike ngaphansi kwe-FDA igunya ngaphandle kokuba inkampani yenza isimangalo sokwelapha noma kukhona imiphumela engacatshangelwa ukuthi i-FDA iyakhathazeka ngayo. Ukuze uphephe kufanele uxoxe nganoma yisiphi isengezo nodokotela wakho ngaphambi kokuqala ukwesekwa futhi uvumele udokotela wakho wazi nganoma yimiphi imiphumela emibi ongayithola.

Funda kabanzi mayelana Nezokwelapha Nezokwelapha Ezihambisana Nezokwelapha

• Iyini Imithi Ephelele Nezokwelapha?
• I-Ginkgo ne-Asthma
• Ingabe enye yokwelapha isifo sofuba esiphumelelayo futhi ephephile

_Imithombo

1. > Kalliomäki M >, Salminen > S >, Poussa > T, Arvilommi H >, Isolauri > E. Ama-Probiotics nokuvimbela isifo esihlasela i-atopic: Ukulandelwa kweminyaka engu-4 kwe- randomized > trial-controlled control. I-Lancet. 2003; 361 (9372): 1869-1871.
2. > Weston S, Halbert A, Richmond P, Prescott SL. Ama-probiotics e-atopic dermatitis: a > okungahleliwe > ukuvivinywa okuvikelwe. I-Arch Dis Child. 2005; 90 (9): 892-897.
3. > Pelucchi C, Chatenoud L, Turati F, Galeone C, Moja L, Bach JF, et al. Ama-probiotics supplementation ngesikhathi sokukhulelwa noma ebuntwaneni ekuvimbeleni i-dermatitis ye-atopic: ukuhlaziywa kwe-meta. Epidemiology 2012; 23: 402-14.

4. > Arietta MC, Stiemsma LT, Dimitriu PA et al. Ubusana bokuqala ukuguquguquka kwamagciwane kanye nokuguquguquka komzimba kuthinta > ingozi > yokuphefumula kwesifo somntwana. Isayensi Yezobuchwepheshe Eyisayensi 30 Sep 2015 >: Vol >. 7, Issue 307, iphe. 307ra152. I-DOI: 10.1126 / scitranslmed.aab2271