I-HPV , noma i-papillomavirus yabantu, ivame ukucatshangwa njengegciwane lomdlavuza wesibeletho . Noma kunjalo, i-HPV ingaphezulu kakhulu kwalokho. Kunezinhlobo ezingaphezu kuka-150 ze-HPV. Izingaphezu kuka-40 zalezi zinhlobo zingadluliselwa ngocansi. Lawo ma-virus enza konke okuvela emagqabeni ajwayelekile esikhumba kuya emagqatsheni angama-genital to cancer .
Inombolo yamanqamu etholakele ukuthi ihlotshaniswa ne-HPV iyakhula.
Izifo ze-HPV ezithathelwana ngokocansi ziye zaboniswa ukuthi zingabangeli nje kuphela umdlavuza wesibeletho. Futhi zingabangela umdlavuza we-penile , umdlavuza we-anal , kanye nomdlavuza we-throat . Ucwaningo lwamuva luye lwabonisa nokuthi kungase kube nokuhlangana phakathi kwe-HPV nomdlavuza wamaphaphu.
Ukubhema yiyona imbangela enkulu yomdlavuza wamaphaphu ezweni laseNtshonalanga. Noma kunjalo, akuyona imbangela kuphela yomdlavuza wamaphaphu. Ama-asbestos, i-radon, nezinye izinhlayiya ezifakiwe zibuye zaxhunyaniswa namanqamu wamaphaphu. Ngakho unezifo eziningana ezithathelwanayo. Ngaphezu kwalokho, izakhi zofuzo, ukuziphatha kanye nezinye izinto zidlala indima ekuthuthukiseni umdlavuza wamaphaphu.
I-HPV ne-Cancer Lung
Akufanele kusimangaze ukuthi ososayensi baye bacabanga ukuthi i-HPV ingase ihlotshaniswe okungenani nengxenyana yamathumbu emaphaphu. I-HPV ayiyazi kuphela ukuthi ibangela umdlavuza. I-Cancer ehlobene ne-HPV itholakale ezicukwaneni eziseduze namapayipi - njengemphimbo namathoni.
Ngamanye amazwi, i-HPV yombili ikwazi ukufinyelela kwamaseli wamaphaphu futhi ingawenza amangqamuzana anomdlavuza.
Eqinisweni, izifundo eziningi zibonise ubudlelwane obuphakathi kwe-HPV nomdlavuza wamaphaphu. Noma kunjalo, isixhumanisi sisalokhu siphikisana kakhulu. Izifundo zamanqamu ahlukahlukene wamaphaphu ahlulekile ukukhombisa i-HPV DNA ema-sampuli azo.
Le miphumela ingase ibonakale iphikisana, futhi yenza abantu babuze ukuthi kufanele bakwethembe isayensi. Noma kunjalo, kunezindlela eziningana ukuthi lokhu kubonakala kungqubuzana kungachazwa.
- I-HPV cishe ihlotshaniswa nomdlavuza wamaphaphu kwezinye izingxenye zomhlaba kunabanye.
Le ncazelo ifakwe kakhulu. Ukusabalalisa kwama-HPV izinhlobo kuyahluka kakhulu ngesifunda. Kanjalo ukusabalalisa kwamanye amagciwane okuye kwabonisa ubudlelwane obuqinile kakhulu ne-HPV ukutheleleka - njengomdlavuza wesibeletho. Iphinde isekelwe yidatha kusuka ekuhlaziyweni kwemeta eye yabona ukuthi imiphumela ye-HPV nemfundo yomdlavuza wamaphaphu ihluka kakhulu ngendawo kodwa kubonakala sengathi ihambisana kakhulu ezindaweni ezithile. I-Cancer yamaphaphu ehlobene ne-HPV, njengaleyo, ibonakala ijwayele kakhulu e-Asia kunaseYurophu. - Izifundo ezitholile i-HPV emathunjini omdlavuza wamaphaphu ziye zahlushwa ukungcola nge-DNA egazini.
Lokhu kungenzeka nakanjani kwezinye izimo. Kodwa-ke, inani elikhulu lezifundo ezitholile izinhlangano phakathi kwe-HPV nomdlavuza wamaphaphu zenza inkinga engaguquki nokungcola akunakwenzeka. - Izifundo ezingatholakali i-HPV emathunjini omdlavuza wamaphaphu azibheki i-HPV ngendlela efanele.
Uma ososayensi bebefuna izinhlobo ezithile ze-HPV ezikhukhuleni futhi bakhetha izinhlobo ezingalungile zokubheka, lokhu kungaba incazelo. Kungase futhi kuchaze ukuthi i-HPV ingabhekwa kanjani kumasampula omdlavuza wamaphaphu uma bekhetha ukuhlolwa okungafaneleki kwegciwane. Ngaphezu kwalokho, kufanele uhlole izicubu ezifanele. Phela, kuphela i-subset yamaphasela emaphaphu cishe ahlobene ne-HPV. Ngakho-ke, ukukhetha amacala angalungile ukuhlola kungabuye kuchaze ukuthi kungani kungekho gciwane elitholakalayo.
Kusobala ukuthi yincazelo yokuqala ezoboniswa ukuthi iqinisile. Umdlavuza we-Lung awufani nomdlavuza womlomo wesibeletho, lapho iningi lamacala abangelwa ukutheleleka kwe-HPV. Esikhundleni salokho, izifundo ezibonise ubudlelwane phakathi komdlavuza wamaphaphu ne-HPV zitholile kuphela igciwane ngengxenyana yezicubu. Inani lamanqamu emaphaphu ahlotshaniswa ne-HPV ahluka kakhulu ngokwezwe kanye noluhlobo lwesisu. Ngaphezu kwalokho, ngisho nezifundo ezibonisa ubudlelwane obuqinile phakathi komdlavuza wamaphaphu ne-HPV abavamile ukuthola igciwane kuma-sampuli angaphezu kuka-10-20.
Lesi yisikhumbuzo esibalulekile ukuthi izinhlobo eziningi zomdlavuza zingaba nezimbangela ezihlukahlukene.
Bangabuye babe nemiphumela ehlukahlukene yemiphumela. Ngesikhathi ukubhema kuhlala kusakazeke emhlabeni wonke, cishe kuyoba yisisusa esikhulu somdlavuza wamaphaphu. Kodwa-ke uma, ngokuhamba kwesikhathi, abantu abambalwa nabambalwa bebhema, khona-ke singabona ukuthi amaphesenti amakhulu amanqamu amaphaphu asele ahlobene nezinye izimbangela - kuhlanganise ne-HPV.
Lelohlobo lokushintsha kwe-causative seluvele lubonakala kumdlavuza we-throat kanye nomlomo. Amaphesenti amakhulu ngonyaka ngamunye abonakala ehlotshaniswa nokutheleleka ngegciwane. Ngenhlanhla, lokho kushintshwa kuye kwahlotshaniswa nokwanda komdlavuza we-throat yomkhuhlane, ama-cancer e-HPV-ahlobene nomdlavuza webhola ebonakalayo ayabulawa kancane kunabo abahlobene nogwayi. Kungakhathaliseki ukuthi umehluko ofanayo wokusinda ungase ube yiqiniso namanqamu amaphaphu ahlobene ne-HPV ahlala ebonakala.
Imithombo:
I-Goto A et al. Ukutheleleka komuntu we-papillomavirus emangqamuzaneni wamaphaphu namasophageal: Ukuhlaziywa kwamacala angu-485 ase-Asia. J Med Virol. 2011 Aug; 83 (8): 1383-90.
Wu DW et al. Ukunciphisa i-p21 (WAF1 / CIP1) ngokuguqulwa komgwaqo we-p53-DDX3 kuhlotshaniswa nokusinda okungekho emuva kokusinda-mahhala emdlalweni wamapayomavirus ohambisana nomuntu wesandulela-ngculazi. I-Clin Cancer Res. 2011 Apr 1; 17 (7): 1895-905. Epub 2011 Feb 16.
Koshiol J et al. Ukuhlolwa kwe-papillomavirus yabantu emathisini amathumbu amaphaphu. J Natl Cancer Inst. 2011 Mar 16; 103 (6): 501-7. Epub 2011 Feb 3.
Joh J et al. I-papillomavirus yabantu (i-HPV) ne-Merkel cell polyomavirus (MCPyV) emdlashini wamaphaphu omncane omncane. Exp Mol Pathol. 2010 Dec; 89 (3): 222-6. Epub 2010 Aug 7.
U-Aguayo F et al. Ubukhona be-papillomavirus-16 yabantu nesimo somzimba emaphashini amaphaphu ase-Asia. I-Cancer Engaguquki Yama-Agent. 2010 Nov 16; 5: 20.
Mehta V et al. Ukuhlaziywa komphakathi kwe-oral and oropharyngeal carcinoma: ukuguqulwa kwemithethonqubo yokuhlukaniswa kwemvelo, ukusinda kanye nesifo sesiguli. I-Laryngoscope. 2010 Nov; 120 (11): 2203-12.
Srinivasan M et al. Uhlobo lwe-papillomavirus lwe-16 no-18 kumanqamu wamaphaphu ayisisekelo - ukuhlaziywa kwemeta. I-carcinogenesis. 2009 Okthoba; 30 (10): 1722-8. I-Epub 2009 Jul 20.
I-Castillo A et al. I-papillomavirus yabantu emaphashini amaphaphu phakathi kwamazwe amathathu aseLatin America. I-Oncol Rep ka-2006, Apr; 15 (4): 883-8.