Njengoba ososayensi baqhubeka nokusebenza ekuqedeni imbangela ye- Alzheimer's , bayaqaphela lapho inkomba iphakama phezulu.
Eminyakeni embalwa edlule, enye yalezi zinkinga- ukucindezeleka- iboniswe yizinhlolovo eziningi zocwaningo mayelana nokulingana kwayo okungenzeka kube khona ingozi yokugula kwesifo se-Alzheimer nezinye izinhlobo ze-dementia .
Isifinyezo se-3 Izihloko Zokucwaninga
Iphephandaba i- Proceedings of the National Academy of Sciences lichaza ucwaningo lapho abacwaningi abathola khona, ngokusebenza namagundane, ukucindezeleka okungokomzwelo okungapheli kubonakala kuthinta impilo yobuchopho.
Amagundane ayebhekene nokucindezeleka okuphindaphindiwe aqala ukuthuthukisa ezinye izingxube ze- tau ze- tau amaprotheni eziwuphawu lobuchopho bomuntu njengo-Alzheimer's. I- hippocampus yayithintekile ikakhulukazi emagundeni, futhi futhi kaningi indawo yochungechunge okokuqala ehlaselwe yisifo se-Alzheimer's.
Ngokuphambene nemiphumela yokucindezeleka okuphindaphindiwe okuphindaphindiwe, amagundane abhekene nobunzima (isikhashana, isiqephu esisodwa isikhathi) akazange ahlakulele lezo zinguquko zengqondo.
Uma kwenzeka okufanayo kubantu, labo kithi ababhekana nokucindezeleka okungapheli empilweni yethu kungaba engozini enkulu yokuthuthukisa isifo se-Alzheimer's. Ngenkathi abanye bezwa ukuthi kuselula ukufaka ucwaningo kumagundane kubantu, isayensi iye yaba nokuphumelela okubalulekile ngokusebenzisa le model.
Enye isifundo eshicilelwe eBritish Medical Journal ichaza ucwaningo olwenziwa eminyakeni engaphezu kwengu-38 nabesifazane abangu-800 eSweden. Lolu cwaningo lulandelele inani lezigameko ezingase zicindezeleke ababambiqhaza ababhekana nazo njengokwesehlukaniso, ubufelokazi, ukugula komndeni, izinselelo zomsebenzi, njll, kusukela ngo-1968 futhi ngezikhathi ezithile kuze kube ngu-2005.
Izimpawu zokucindezeleka nazo zihlolwe ngezikhathi ezithile. Ucwaningo lwathola ukuthi inani labacindezeli bezingqondo (izenzakalo ezingokoqobo) kanye nokubona kwabesifazane ngezenzakalo (ukucindezeleka ababhekana nazo) kokubili kwazimele ngokuzibandakanya nengozi eyengeziwe yokuthuthukisa ukugula komzimba ngokuhamba kwesikhathi.
Ucwaningo lwesithathu lubuyekeze izifundo eziningi zokucwaninga zangaphambilini futhi lwaphetha ngokuthi ngenkathi kukhona ngokusekela ngokucacile uxhumano phakathi kokucindezeleka nokusebenza kwengqondo , ubufakazi abuqinile ngokwanele ukunquma ukuthi ukucindezeleka kubangela isifo se-Alzheimer. Kunalokho, kubonakala sengathi kungenye yezici eziningana ezingakwandisa ingozi yokuncipha kwengqondo.
Ukubhekana nokunciphisa, Ukucindezeleka
Ukwehlisa ukucindezeleka empilweni yakho- nokubhekana nayo ngezindlela eziphumelelayo-kakade kunconywa kokubili impilo yakho engokomzimba nengokomzwelo. Ukukwazi ukunciphisa ingozi yesifo se-Alzheimer kukunika isizathu esengeziwe sokucabangela ukushintsha impilo.
Imithombo:
I-Alzheimer's & Dementia: I-Journal ye-Alzheimer's Association. Umqulu 10, Issue 3, Supplement, Amakhasi S155-S165, Juni 2014. Ukucindezeleka, i-PTSD, nokuphefumula komqondo. http://www.alzheimersanddementia.com/article/S1552-5260(14)00136-8/fulltext
BMJ 2013; 3: Ukucindezeleka okuvamile kwengqondo kubantu besifazane abaneminyaka ephakathi nendawo ehlobene nokucindezeleka okudluleleko kanye nokwanda kakhudlwana kwesifo se-Alzheimer: inhlolovo yabantu abaneminyaka engu-38 ubudala. http://www.bmjopen.bmj.com/content/3/9/e003142
Izinqubo ze-National Academy of Sciences. Ngo-Ephreli 17, 2012. vol. 109 cha. 16. Imiphumela ye-Corticotropin-releasing factor receptor encike ekucindezelweni okuphindaphindiwe ku-tau phosphorylation, ukuzenzekelayo, nokuhlanganiswa. http://www.pnas.org/content/109/16/6277.abstract