Ukubambisana Kwezifo Ezizimele
I-autoimmune syndrome eminingi, ngencazelo, yinto ehlanganisiwe yezifo okungenani ezi- autommune ezintathu kumuntu ofanayo. Cishe amaphesenti angama-25 alabo abanesifo esizimele bajwayele ukuthuthukisa ezinye izifo ezizimele. Abantu abane-multipleimmune syndrome amaningi banesimo okungenani esisodwa se-dermatological (isikhumba), esivame ukuba yi- vitiligo noma i- alopecia areata .
Ukubambisana kwezifo ezinhlanu zokuzilimaza kubhekwa njengokungavamile kakhulu.
Ukuhlukaniswa kwe-Multiimmune Syndrome eminingi
Uhlelo lwezigaba lwakhelwe abantu abanezifo ezimbili ezizenzekelayo ngokusekelwe kwezimo ezithile ezenzeka ndawonye. Uhlelo lokuhlukanisa, oluhlukanisa i-autoimmune syndrome eningi, luwusizo ekutholeni isimo esisha uma izimpawu ziqala kuqala. Kuyasiza ukunquma lapho isimo sesithathu cishe "singena khona."
- Thayipha i-Autoimmune Syndrome eyi-1 eminingi - i- myasthenia gravis , thymoma, i- polymyositis , i-giant cell myocarditis
- Thayipha i-Autoimmune Syndrome ye-Multiple Multiple - Isifo se-Sjogren , isifo samathambo esifubeni , i-cirrhosis eyinhloko ye-biliary, i- scleroderma , isifo se-autoimmune
- Uhlobo lwesithathu lwe-Autoimmune Syndrome - yenza isifo se-autoimmune, i-myasthenia gravis kanye / noma i-thymoma, isifo se-Sjogren, i-anemia, i-idiopathic thrombopenic purpura, isifo se-Addison, uhlobo lwesifo sikashukela, uhlobo lwe-diabetes, i-vitiligo, i-autoimmune i-hemolytic anemia, i- systemic lupus erythematosus , i-dermatitis herpetiformis
Imbangela ye-Autoimmune Syndrome eminingi
Izindlela eziyinhloko eziholela ku-autoimmune syndrome eziningi aziqondi ngokugcwele. Lokho kusho ukuthi abacwaningi basolisa ukuthi kuhilelekile ukuthi izimbangela zezemvelo kanye nokutholakala kwezakhi zofuzo zihilelekile. Kuyaziwa ukuthi ezinye ze-autoantibodies zikhona ezimweni ezithile kanye nezinhlelo zezinhlaka eziningi zingathinteka.
Ngenxa yokuthi izimo eziningi ezizenzakalelayo zingenzeka kumuntu ofanayo, noma emndenini, indlela yokuzivikela ehambisana nokuzimela ihilelekile.
Imiphumela evela ekuhlaziyweni kwe-meta eshicilelwe ku-Nature Medicine (2015) yembula ukuthi ezikhungweni eziyi-10 ezizimele ngokuqala ekuqaleni kwasebuntwaneni, kunezibonakaliso ezingu-22 zezafu ezabiwe izifo ezimbili noma ngaphezulu futhi ezingu-19 zabiwe okungenani izifo ezintathu ezizimele. Izimbonakaliso eziningi ezitholakalayo zazitholakala ezindleleni ezixhunyaniswe nokusetshenziselwa kwamaseli, ukwanda kwamaseli, nezinhlelo zokubonisa ukuthi zidlala indima ebalulekile ohlelweni lokuzivikela- kanye nezinqubo ezizimele, ikakhulukazi. Izifo eziyi-10 ezizimele zenza uhlobo lwesifo sikashukela , isifo se-celiac , i- juvenile idiopathic arthritis , isifo esivamile sokuguquka kwamagciwane, i-systemic lupus erythematosus, isifo se-Crohn, i-ulcerative colitis, i- psoriasis , i-autoimmune thyroiditis, ne- ankylosing spondylitis .
Olunye uhlobo lwezinhlobo ze-genome-wide luye lwathola amagciwane amakhulu okuthola amandla phakathi kwezifo ezithathelwana ngokuzenzakalela ezithinta kakhulu abantu abadala. Nakuba ukuhlonza izakhi zofuzo kusisiza ukuba siqonde imbangela ye-autoimmune syndrome eminingi, kungase kuholele nakwezinye izinhloso zokwelashwa.
Ngenkathi inhlanganisela ethile yezinhlobo zezofuzo kanye nezimbangela zemvelo yikho ukucabanga kwamanje, ezinye izinto eziye zenziwa ngabacwaningi.
Kuye kwaphakanyiswa ukuthi uma izidakamizwa zokuzivikela zingeniswa ukuze zilaphe isifo esisodwa sezimoto, ukuguqula amasosha omzimba kungase kwenzeke lapho kuqhutshwa ukuthuthukiswa kwesinye isifo somzimba.
Izifo ezimbili noma eziningi ezithathelwanayo ngokuzenzakalelayo ku-Rheumatology
Ukubambisana kwezifo ezimbili noma ngaphezulu ezizimele ngokuzenzakalelayo akubhekwa njengokuvamile. Ngokuvamile kubonakala nge-systemic lupus erythematosus, isifo samathambo, isifo se-scleroderma, isifo se-Sjogren, i- vasculitis , ne-polymyositis.
Ucwaningo lubonise ukuthi i-arthritis ye-rheumatoid kanye ne-autoimmune thyroiditis ziphakathi kwezifo ezivame ukuguqula izifo ezitholakala emphakathini jikelele.
Ngokusho kweHealio Rheumatology, uma umuntu enesinye sezimo ezimbili, ingozi yokuthuthukisa enye ingu-1.5 izikhathi eziphakeme kunalabo abangenakho isimo.
Ngokuthakazelisayo, kukhona ubudlelwane obuphambene phakathi kwe-arthritis ye-rheumatoid kanye ne- multiple sclerosis , okusho ukuthi uma unesinye sezimo ezimbili, kunomthelela wokunciphisa ukwehlisa omunye. Ngenkathi singakwazi ukubiza lokho okungaqondakali, ukuhlukahluka kwezakhi zofuzo kunganikeza isizathu.
Kufanelekile ukuphawula ukuthi izifo ezizimele zivame kakhulu kubantu besifazane kunamadoda. Umehluko wobulili uneza uhlaka lwezinkinga kubacwaningi abazama ukuthola ingozi yokuthuthukisa isimo sesibili sokuzimela noma i-autoimmune syndrome eminingi. Ingabe ingozi iyafana nabesilisa nabesifazane? Kuningi okwamanje okumele kufundwe.
Izwi elivela
Kubantu abanesimo esisodwa se-autoimmune, kumele bahlale beqaphele ukuthuthukiswa kwezinye izimo ezizimele. Kuyaziwa ukuthi izifo eziningi ezizimele zenzeke ngokuvama okukhulu phakathi kwalabo okungenani isimo esisodwa sezimoto. Hlala uxoxisana nezinguquko ozibona esimweni sakho nodokotela wakho. Ukuxilongwa kokuqala kanye nokwelashwa kusebenza kahle.
> Imithombo:
> Anaya JM et al. I-Multiple Autoimmune Syndromes. Imigomo Yokuthola Izifo Ezizimele. Springer. 2008.
> Cojocaru M, et al. I-Autoimmune Syndrome eminingi. UMedica (uBuchar). April 2010.
> Li YR et al. Ukuhlaziywa kwe-Meta ye-Genetic Architecture Ephakathi Nezifo Eziyishumi Eziphathelene Nezifo Ezizimele. Nature Medicine 2015.
> Ukuhlala Ngaphambi Kokuhlukunyezwa Kwama-autoimmune amaningi. I-Healio Rheumatology. Agasti 2016.