I-Polycystic ovarian syndrome, noma i- PCOS , yisimo lapho ama-ovari womama wesifazane nama-gland adrenal akhiqiza ama-androgens amaningi kunokujwayelekile, okubangelwa ukwanda kwezinwele zomzimba, izinwele zomzimba nezikhathi ezingavamile.
Ngesikhathi abacwaningi bengacacisi imbangela eqondile ye-PCOS, kwaziwa ukuthi ukungalingani kwesistimu ye-endocrine kubhekene nezinguquko eziningi ezihambisana nayo.
Noma kunjalo, kusasaziwa ukuthi yini ebangela lezo zinguquko.
Nasi ukubheka izinkolelo eziyinhloko ezikholelwa ukuthi zingemva kwe-PCOS:
I-Hypothalamic-Pituitary-Ovarian Axis
Ama-hormone amaprotheni akhiqizwa isakhiwo ngaphakathi komzimba okwenza ushintsho ngaphakathi kweseli noma isitho. I-axpot Hypothalamic-Pituitary-Ovarian (HPO) iyisimiso sokulawula ama-hormone ngaphakathi komzimba.
I-hypothalamus ingumgogodla ngaphakathi kobuchopho ukuthi, lapho ivuselelwe, iveza i-hormone, eyaziwa njengeGonadotropin-Releasing Hormone noma i-GnRH. I-GnRH iya egijimini se-pituitary, esinye isakhiwo esincane ebuchosheni. I-pituitary gland ikhiqiza ama-hormone ahlukahlukene alawula nokugcina imisebenzi eminingi yomzimba.
Okubalulekile ku-PCOS, i-pituitary iveza i- FSH , noma i-Follicle Stimulating Hormone, ne- LH , noma i-Lutenizing Hormone. I-LH ihambela e-ovary lapho ivuselela ukukhiqizwa kwe- androgens .
Kuye kwacatshangelwa ukuthi amazinga aphezulu okuqhubekayo e-LH ne-androgens, okuyi-testosterone, enza i-PCOS.
Noma kunjalo, lokhu akusho ukuthi kungani abesifazane abaningi abane-PCOS bengenayo amazinga aphezulu we-LH.
Ukuxhumeka kwe-Insulin-Androgen
I-insulini iye yacatshangwa ukuthi ineqhaza ekuthuthukiseni i-PCOS. Ngaphezu kokulawula amazinga e-glucose, i-insulin ibangela isibindi ukwehlisa ukukhiqizwa kwe-molecule eyisihluthulelo eyaziwa njenge-sex-hormone-globant binding, noma i-SHBG.
I-Testosterone ithathwa egazini nge-SHBG lapho i-molecule ikhona. Uma inani elincane le-SHBG litholakala, i-testosterone engaphezulu yamahhala (i-testosterone engathathwa yi-SHBG) igazini. Kukholelwa ukuthi amazinga aphezulu e-insulini angakhuphula inani le-androgens elikhiqizwa yi-ovary.
Lokhu futhi akuchazi ngokugcwele i-PCOS, njengoba abesifazane abaningi abane-PCOS bengenakho ukumelana ne-insulin , ushintsho ngendlela amangqamuzana omzimba abhekana ngayo ne-insulini, kanye nezindaba ezivamile ezibonwe ku-PCOS.
I-Genetics
Isici esisodwa esiyinhloko i-PCOS yukuthi ekugijimeni emindenini. Abesifazane abane-PCOS bavame ukuba nodadewabo, umama, umzala noma ukanina onesimo. Ngenkathi odokotela bengasazi isizathu esiqondile, kusobala ukuthi kunesixhumanisi sokuzalwa.
Nsuku zonke abacwaningi basondela ekuboneni ukukhubazeka kofuzo okungenzeka kube nephutha. Lokhu kunzima ngenxa yokungabi nalutho lokuhlola okufanayo kanye nendima izinto zangaphandle (ezifana nokukhuluphala, ukudla nokuzivocavoca) ezingadlala ekuthuthukiseni lesi sifo.
Imithombo:
UHarris, uColette no-Carey, u-Adam. I-PCOS: Umhlahlandlela Wesifazane Wokubhekana NePycycystic Ovary Syndrome .UHorson; ELondon. 2000.
U-Thatcher, uSamuel. I-PCOS: Ubhubhane Olufihlekile . Imizamo yokuCindezela; I-Indianopolis. 2000.
Prapas N, Karkanaki A, Prapas I, Kalogiannidis I, Katsikis I, uPanidis D. Genetics we-Polycystic Ovary Syndrome. Hippokratia . 2009; 13 (4): 216-223.