Ingabe lokhu Kungasiza Usizo Lwe-Thiamine?
I-Benfotiamine ingumuthi ovela ku-thiamine (i-vitamin B eyaziwa nangokuthi i-vitamin B1). Ukusebenzisa i-benfotiamine kuthiwa kukhulisa amazinga akho okuthiwa i-thiamine futhi, futhi, kuvikela izimo zezempilo ezihambisana namazinga aphansi e-thiamine.
I-thiamine itholakala ekudleni okuhlukahlukene okubandakanya inyama, izinkukhu, amaqanda, nezinhlamvu eziqinisiwe ezifana nesinkwa, okusanhlamvu, i-pasta, irayisi kanye nofulawa.
Abantu abadla kakhulu i-carbohydrate ehlanjululwe (njengelayisi omhlophe nemikhiqizo efulawa omhlophe ongagciniwe) noma ugweme okusanhlamvu kungenzeka kube engozini enkulu yokuntuleka kwe-thiamine, njengalabo abanesifo sohudo eside, isifo se-Crohn, nokuxhomeka kotshwala. Ukuzivocavoca okunamandla nemibandela efana ne-hyperthyroidism yandisa isidingo somzimba we-thiamine.
Ukusetshenziswa
Amazinga e-thiamine aphansi ahlotshaniswa nezinkinga zezempilo, kuhlanganise nezinkinga zesifo sezinzwa nezinhliziyo. Njengoba i-benfotiamine ibonakala inempilo ephakeme kune-thiamine, abanye abantu bayayisebenzisela ukwandisa amazinga abo we-thiamine nokuphatha izimo ezithile zempilo.
Isibonelo, i-benfotiamine ivame ukufakwa njengendlela yokwelapha yemvelo kulezi zimo ezilandelayo:
- Ukukhathazeka
- Ukuhlungu obusemhlane
- Ukucindezeleka
- Isifo sikashukela
- I-FIbromyalgia
- I-neuropathy (kuhlanganise ne-diabetes neuropathy neuropathy ngokweqile)
- Sciatica
- Isifo segilo (njengesifo sikaHashimoto)
Ukwengeza, i-benfotiamine kuthiwa ihlehlise inqubo yokuguga, ivuselele ukusebenza komzimba, ivuselele imizwa, ithuthukise ukusebenza kobuchopho, iphinde inciphise i-lactic acid buildup emzimbeni.
Abanye abaxhasayo futhi bakhombisa ukuthi i-benfotiamine ingavikela umzimba emiphumeleni eyingozi yemikhiqizo ekupheleni kwe-glycation (AGEs).
Uhlobo lwamakhemikhali olutholakala enyameni nakwezinye ukudla (ikakhulukazi okuthosiwe, okugcoziwe, okubhakiwe noma okugcoziwe), ama-AGE angabangela ukuvuvukala futhi abe nomthelela eziningana zezindaba zezempilo.
Izinzuzo
Kuze kube manje, izifundo ezimbalwa ziye zahlola izinzuzo zezempilo ezingase zithathwe ngokuthatha izithako ze-benfotiamine. Nakhu ukubuka okunye okufundwayo okufundwayo:
1) Isifo sikashukela
I-Benfotiamine ingase ibe nenzuzo ethile kubantu abanesifo sikashukela, ngokusho kocwaningo olwanyatheliswa ku- Diabetes Care ngo-2006. Ukucwaninga, abantu abangu-13 abanesifo sikashukela banikezwa ukudla ngokuqukethwe okuphezulu kwama-AGE ngaphambi nangemva kwezinsuku ezintathu zokudla ama-1,050 mg we-benfotiamine nsuku zonke. Imiphumela yocwaningo ibonise ukuthi i-benfotiamine ibonakala ivikela ukucindezeleka okwenziwe nge- oxidative ngenxa yokudla kwama-AGE.
Esicwaningweni sika-2010 eshicilelwe ku- Diabetes Care , noma kunjalo, abacwaningi baphenyisisa umphumela we-benfotiamine kubantu abane-type 2 yesifo sikashukela ne-nephropathy. Ukuze kuhlolwe, abahlanganyeli bathatha i-benfotiamine noma i-placebo nsuku zonke amasonto angu-12. Imiphumela yabonisa ukuthi i-benfotiamine ayizange igweme ukukhipha i-albin ye-albin (ukuhlolwa okusetshenziselwa ukuqapha isifo sezinso) noma amazinga we-KIM-1 (umonakalo wokulimala kwezinso).
Isifundo sezinyanga ezingu-12 eshicilelwe ku- PLoS One ngo-2012 sithole nokuthi i-benfotiamine ayizange ithinte kakhulu amamaki aholela ekucindezelweni kwe-vascular-induced circulars.
Okuhlobene: Izixazululo zemvelo zesifo sikashukela
2) I-Neuropathy yesifo sikashukela
Ucwaningo oluthile oluncane lubonisa ukuthi i-benfotiamine ingasiza ekwelapheni ukwelashwa kwesifo sikashukela (isimo esibonakaliswe ukulimala komzimba okubangelwa ukuphakama okuhlobene nesifo sikashukela emazingeni ashukela egazini).
Ucwaningo luka-2012 oluvela ekunakekelweni kwesifo sikashukela , kodwa, lwathola ukuthi izinyanga ezingu-24 zokwelashwa nge-benfotiamine azizange zibe nemiphumela emibi emsebenzini wezinzwa zomzimba noma izimpawu zokuvuvukala kwabahlanganyeli abane-type 1 yesifo sikashukela.
3) Izifo ze-Alzheimer's
I-Benfotiamine ibonisa isithembiso sokwelashwa kwesifo se- Alzheimer , ngokusho kwesifundo esincane sika-2016 eshicilelwe ku- Neuroscience Bulletin .
Abahlanganyeli abahlanu abane-Alzheimer's mildness to moderate bathatha i-benfotiamine (300 mg nsuku zonke) izinyanga ezingu-18.
Ekupheleni kwesifundo, abahlanganyeli abahlanu babonisa ukuthuthukiswa kwengqondo. Abacwaningi bahlola abathathu abahlanganyeli nge-PET scan futhi bathola ngcono uma kuqhathaniswa nokuhlola kwabo kokuqala.
Imiphumela Ezingenakwenzeka
Nakuba kuncane okuyaziwa ngokuphepha kokuthatha i-benfotiamine isikhathi esithile, kukhona ukukhathazeka ukuthi izithako ze-benfotiamine zingabangela imiphumela eminye yemiphumela emibi (njengokucasula isisu, isisulu, isizungu, ukulahlekelwa izinwele, inzuzo yesisindo, iphunga lomzimba, nokunciphisa e-blood pressure).
Abantu abanesihawu ngesulfure kufanele bagweme i-benfotiamine.
Isilinganiso esiphephile futhi esiphezulu kakhulu se-benfotiamine asikwaziwa okwamanje. Uma ucabangela ukwesekwa, khuluma nomhlinzeki wakho wokunakekelwa kwezempilo ukunquma ukuthi yini, uma ikhona, isilinganiso se-benfotiamine kufanelekile kuwe.
Futhi, khumbula ukuthi ukuphepha kwezidakamizwa kwabesifazane abakhulelwe, omama abahlengikazi, izingane, nalabo abanezimo zezokwelapha noma abaphuza imishanguzo ayisungulwa. Ungathola amathiphu amaningi kokusebenzisa izithako lapha .
Lapho Uzoyithola khona
Etholakala kakhulu ukuthengwa ku-intanethi, izithako ze-benfotiamine zingatholakala nakwezinto eziningi zokudla ezendalo kanye nasezitolo ezikhethekile ezisekelweni zokudla.
I-Takeaway
Nakuba i-benfotiamine ingaba isithako esithembisa isifo se-Alzheimer's, izinkinga zesifo sikashukela, nezinye izimo ezibandakanya ukuphela kwemikhiqizo ye-glycation, akuwona zonke izifundo ezibonise izinzuzo. Asikwazi ukuqina ngokuxhumeka kuze kube yilapho kunesilingo esikhulu semitholampilo.
Amakhemikhali amaningi ekudleni nawo ahlolwe njengama-inhibitors we-AGE. Isibonelo, izifundo zangaphambilini zikhomba ukuthi i-quercetin (etholakala kuma-capers, anyanisi, ama-cranberries, nama-apula), ama-catechines (ngohlobo oluhlaza), kanye ne-resveratrol (ngamagilebhisi abomvu, ama-blueberries, iwayini elibomvu, ne-chocolate elimnyama) lingavimbela ama-AGE. Ukugwema ukudla okuphezulu kuma-AGE kungabuye kuhambe ngendlela ende.
Imithombo:
> Alkhalaf A, Kleefstra N, Groenier KH, et al. Imiphumela ye-benfotiamine ekupheleni kwe-glycation endproducts kanye namakaki wokungasebenzi okuphelile nokuvuvukala kwe-nephropathy yesifo sikashukela. PLoS One. 2012; 7 (7): e40427.
> Alkhalaf A, Klooster A, van Oeveren W, et al. Isivivinyo somtholampilo esiphethwe kabili, esingenangqondo, esihleliwe nge-placebo ekwelapheni kwe-benfotiamine kwiziguli ezine-nephropathy yesifo sikashukela. Ukunakekelwa yisifo sikashukela. 2010 Julayi; 33 (7): 1598-601.
> Fraser DA, Diep LM, uHovden IA, et al. Imiphumela ye-long-term oral benfotiamine supplementation emisebenzini yezinzwa zomzimba kanye nezimbangi zokuvuvukala kweziguli ezine-type 1 yesifo sikashukela: inyanga engu-24, ephindwe kabili-eyimpumputhe, ehleliwe, engahleliwe nge-placebo. Ukunakekelwa yisifo sikashukela. 2012 Meyi; 35 (5): 1095-7.
> I-Pan X, i-Chen Z, i-Fei G, ne-al. Ukuthuthukiswa Kwengqondo Okude Kwesikhathi Eside Ngemva kokulawulwa kweBenfotiamine kwiziguli ezinezifo ze-Alzheimer's. I-Neurosci Bull. I-2016 Dec; 32 (6): 591-596.
> Ukuziphendulela: Ulwazi oluqukethwe kule sayithi luhloswe ngezinjongo zemfundo kuphela futhi aluthathi iseluleko, ukuxilongwa noma ukwelashwa ngudokotela ovunyelwe. Akuhloselwe ukumboza zonke izinyathelo zokuqapha, ukusebenzisana kwezidakamizwa, izimo noma imiphumela emibi. Kufanele ufune ukunakekelwa okusheshayo kwezokwelapha kunoma yiziphi izinkinga zezempilo bese uthintana nodokotela wakho ngaphambi kokusebenzisa enye imithi noma wenze ushintsho ohlelweni lwakho.