Umdlavuza wesibeletho uhlotshaniswa kakhulu nokudla nokuziphatha ngendlela yokuziphatha. Bobabili ukukhuluphala nesifo sikashukela nabo baxhunyaniswe nomdlavuza ngenxa yemiphumela yokukhula ekhuthaza i-insulin. Ngakho ukungenelela okuzosiza ukugcina i-glucose yegazi emkhakheni onempilo kungasiza ekuvimbeleni kuphela isifo sikashukela sohlobo lwe-2, kodwa futhi nomdlavuza wesifuba.
Ukuphazanyiswa kwezilinganiso ezivamile zomphakathi nakho kuhlotshaniswe nomdlavuza webele.
Izisebenzi zokuhamba ebusuku zitholakale ezifundweni eziningi ukuze zibe nenengozi enkulu kunalabo abanesimiso esivamile, ezihambisana nomjikelezo wokukhanya / omnyama.
Ngakho-ke, ngaphezu kokudla okunempilo, ukushintshwa okulula okulula-okuphela kokudla ekuqaleni kokuhlwa-kungathuthukisa kokubili ukugaya umzimba kwe-glucose nokulinganisa iwashi, okuholela ekunciphiseni ingozi yomdlavuza webele.
Sasihlale sincoma isikhathi sokuzila ukudla isikhathi eside-isikhathi phakathi kwesidlo kusihlwa nasekuseni kwasekuseni ekuseni-ukukhulisa ukuphulukisa nokulungisa. Isigaba sezinhlanga siqala lapho ukugaya sekuqediwe, futhi ukukhishwa kwe-detoxification nokulungiswa kuyenzeka. Ucwaningo seluqoqiwe olubonisa ukuthi amakholori asetshenziswe kusihlwa futhi isikhathi sokuzila ebusuku (isigaba samathambo) sithinta ama-biomarker ahlobene nomdlavuza webele.
Isikhathi sokuzila ebusuku, ukuvuvukala, nokulawulwa kweGlycemic
Abahlanganyeli ocwaningweni basebenzisa i-NHANES (i-National Health and Nutrition Examination Survey) idatha yabesifazane abangu-2,650 bathola ukuthi labo abadla ingxenye enkulu yamakhalori abo nsuku zonke kusihlwa (5:00 pm - 12:00 ekuseni) babe namazinga aphezulu e- C- amaprotheni asebenzayo (CRP) , umaka wokuvuvukala.
Ukwanda kwamaphesenti angu-10 kwinani lama-kilojoule adliwe kusihlwa, kwaba nokwanda kwamaphesenti angu-3 ku-CRP. Abesifazane ababenesikhathi eside sokuzila isikhathi eside besinezilinganiso eziphansi zamaRPP (ukunciphisa amaphesenti angu-8 kwehora ngalinye elengeziwe), kodwa lokhu kwakungokoqobo kwabesifazane ababengadla ngaphansi kwamaphesenti angu-30 amakhalori abo kusihlwa.
Isikhathi eside esisezingeni lesikhathi kanye nokushintsha ukudla okudlule ngosuku kungasiza ukugcina ukuvuvukala phansi.
Esinye isifundo sasebenzisa idatha ye-NHANES ukuze ilandise isikhathi sokudla ebusuku ngokubambisana nokulawulwa kwe-glycemic. Abesifazane ababika ukuzila ukudla isikhathi eside ubusuku bonke babudla amakholori ambalwa, amakholori adliwa emva kwehora leshumi ekuseni, nenani elincani lokudla okuphelele kanye nokudla okudliwayo nsuku zonke. Amahora amathathu engeziwe okuzila ukudla ebusuku ahlotshaniswa nokunciphisa amaphesenti angama-4 emaphoyiseni we-postprandial (ngemva kokudla), ne-19 amaphesenti angaphansi kweHbA1c .
Lezi zifundo azizange zibhekane nomdlavuza webele ngokuqondile. Kunalokho, babheka ama-biomarker ahlobene nobungozi. Ucwaningo olulodwa olubalulekile lwaluqoqa idatha yokudla kwabesifazane abanomdlavuza webele ukuze banqume ukuthi kukhona ukuxhumana phakathi kwesikhathi sokuzila ebusuku nokuphindaphinda kwesifo.
Isikhathi sokuzila ukudla kwabesifazane abane-Cancer Breast
Kulesi sifundo, idatha yokudla iqoqwe kusuka ku-2413 abesifazane abanomdlavuza wesifuba ekuqaleni, ngonyaka owodwa, neminyaka engu-4. Isikhathi sokuzila sisho amahora angu-12.5 ubusuku bonke, futhi abahlanganyeli babehlukaniswe kulabo abazila ukudla ngaphansi kwamahora angu-13 noma labo abazila ukudla amahora angu-13 noma ngaphezulu. Ukuzila ukudla okungaphansi kwamahora angu-13 kuhlotshaniswa nokukhuphuka kwamaphesenti angu-36 ekuphindaphindiwe komdlavuza webele ngenxa yokulandelwa kweminyaka engu-7.
Kwakukhona nokunciphisa ku-HbA1c ngokuzila ukudla okude isikhathi eside; ukunyuka kwamahora angu-2 kokuzila ukudla kwakuhlanganiswe ne-0.37 iphuzu eliphansi le-HbA1c. Olunye oluthakazelisayo olutholakala kulolu cwaningo ukuthi abesifazane ababenenkathi yokuzila ebusuku babelala amahora amaningi. Ukwandisa isikhathi sokuzila ebusuku kubonakala sengathi kuyindlela yokuguqula indlela yokuphila nemiphumela ebalulekile yokuvikela umdlavuza webele.
Isikhathi Esiningi Esigabeni Sezinkanyezi: Imodi Yokuphulukisa Nomzimba Wokulungisa
Ngemuva kokudla, kunezigaba ezimbili ze-metabolism: ngesikhathi sesigaba se-anabolic, i-blood glucose ikhuphuka, kanti enye yayo isetshenziselwa amandla kanti ezinye zazo zigcinwa njenge-glycogen.
Ngokuhamba kwesikhathi, i-glucose yegazi ibuyele emuva kokuqala; ke-ke, phakathi nesigaba sezinhlanga, umzimba udiliza iglycogen egcinwe amandla. Lapho izitolo ze-glycogen zihamba phansi, umzimba uqala ukusebenzisa amafutha amaningi amaningi. Ngesikhathi sesigaba esilandelayo se-catabolic (isikhathi sokuzila), umzimba usebenza ekulungiseni nasekususweni kwezingxenye zeselula nezonakalisiwe, futhi umzimba wakha ukumelana nokucindezeleka.
Ukuzila isikhathi eside (izinsuku eziningana) kutholakale ukusiza ukunciphisa umsebenzi we-insulin kanye ne-IGF-1 yokuguqula izindlela, ukunciphisa ukuvuvukala, ukunciphisa ukucindezeleka kwegazi, nokuthuthukisa ukuzwela kwe-insulin. Kubonakala sengathi ukudla okuvamile, okude isikhathi eside kungase kuveze ezinye zezinzuzo ezifanayo.
Isikhathi sokudla kanye nesigqi se-circadian
Iwashi lenkosi e- hypothalamus ibeka isigqi esekelwe emjikelezweni wokukhanya / omnyama, futhi kukhona amawashi omzimba ezithombeni eziningi. Iwashi lezingxenye zesibindi, isibonelo, livuselelwa uma sidla. Umqondo wukuthi uma sidla ebusuku, amanye amawashi e-peripheral ahlukumezi newashi le-master. Ukuqeda ukudla kwethu usuku olwedlule kudla okunye ukuvumelanisa nemigqi yethu ye-circadian, okuholela ekuqondaneni kwewashi lethu le-circadian kanye nokulala okungcono kakhulu.
Ukuzwela kwe-insulini kunesigqi sayo sangaphakathi; liphakeme kakhulu ekuseni futhi liphansi ebusuku, ngakho-ke kunengqondo ukuphelisa iwindi lokudla ngaphambi kwesikhathi kungakusiza empilweni yethu. Lo mbono kuqala ngokucwaninga usekela lokhu, njengoba i-CRP yayiphezulu kwabesifazane abadla ama-calories amaningi kusihlwa. Kufanele kube nini isikhathi sakho sokulala ebusuku? Ngokusekelwe ocwaningweni, amahora angu-13 yisiqalo esihle, futhi isikhathi eside singase sibe ngcono.
> Imithombo:
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> Wang F, Yeung KL, Chan WC, et al. Ukuhlaziywa kwe-meta ebuhlotsheni bokuphendula umthamo phakathi komsebenzi wokushisa ebusuku kanye nengozi yomdlavuza webele. U-Ann Oncol 2013, 24: 2724-2732.
> Marinac CR, Sears DD, Natarajan L, et al. Ukuvama nokudla kwesikhathi sokudla kungase kuphazamise ama-Biomarkers of Inflammation kanye nokuphikiswa kwe-insulin ehambisana neengozi yebelevuza. PLoS One 2015, 10: e0136240.
> Marinac CR, Natarajan L, Sears DD, et al. Ukuzila ukudla okwesikhashana kanye nekhanda lomdlavuza webele: Ukuthola okuvela ku-NHANES (2009-2010). I-Cancer Epidemiol Biomarkers Ngaphambi kuka-2015, 24: 783-789.
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