I-Possible Promise to Addition to Thyroid Treatment
Okunye okuthembisayo okutholayo ekutadisheni isifo se-thyroid ukuqonda ubuhlobo phakathi kohlobo oludumile lwesifo sikashukela se- metformin (igama lomkhiqizo we-glucophage) ne-thyroid.
I-Metformin isetshenziselwa ukwelapha uhlobo lwesifo sikashukela sohlobo lwesifo sikashukela kanye nesimiso se-insulin. Kukhona isixhumanisi esiqondakala kahle phakathi kwe-insulin ukumelana- amazinga angaphezu kwejwayelekile e-insulini, enezinga eliphakeme eliphakeme legazi le-glucose elibonisa ukuthi i-insulini ayiphumeli ekunciphiseni ushukela wegazi-hhayi nje kuphela ukugcoba kwegciwane le-thyroid (goiter), kodwa ukusabalalisa okwedlula kokubili ama-nodules wegciwane kanye nomdlavuza we-thyroid.
Kuyathakazelisa ukuthi ucwaningo olusha olwanyatheliswa kuyi- Journal of Endocrinology lithole ukuthi iziguli eziphathwe nge-metformin zinenani elincane le -roid nezinga eliphansi le-TSH, kodwa futhi zanciphisa izingozi ze-goiter, ama-nodules we-thyroid nomdlavuza we-thyroid.
Mayelana ne-Metformin
I-Metformin, edayiswa ngaphansi kwegama lomkhiqizo we-Glucophage, ibhekwa njengesilonda semithi yokuqala esetshenziselwa ukwelapha uhlobo lwesifo sikashukela sohlobo lwesibili , ikakhulukazi ezigulini ezinamandla kakhulu . I-Metformin iyi- biguanide , okusho ukuthi inciphisa ukukhiqizwa kwe-glucose yesibindi sakho, futhi yandisa ukuzwela komzimba wakho kwi-insulin. I-United States yaqala ukusebenzisa i-metformin ngo-1995, futhi i-metformin manje iyisidakamizwa somlomo esetshenziswa kakhulu kunazo zonke ngohlobo lwesifo sikashukela emhlabeni wonke. E-United States, izindleko ezijwayelekile ze-metformin therapy zivela ku-$ 5 kuya ku-$ 25 ngenyanga.
I-Metformin ne-Your Thyroid
Ucwaningo olukhulu olubikwe kwi- Journal of Endocrinology lubuke ubudlelwane obuphakathi komsebenzi we-metformin nesifo se-thyroid futhi kufingqa imiphumela eminingi ebalulekile ye-metformin enomthelela wezokwelapha esikhathini esizayo.
Ngokuqondile, isifundo sabike ngezifinyelo eziningana eziyinhloko:
- I-Metformin ne-Cancer Cancer: Izibalo eziningi zokucwaninga zibonisa ukuthi i-metformin iyanciphisa ukwanda kwamagciwane e-thyroid, futhi inezinto eziyaziwa ngokuthi umsebenzi olwaphikisayo. I-Metformin yanciphisa kakhulu ikhono le-insulin ukukhuthaza ukukhula kwamangqamuzana e-thyroid ahlukahlukene, futhi amangqamuzana omdlavuza we-thyroid, kuhlanganise namalungu omdlavuza we -thyroid . I-Metformin ibuye ivimbele ukukhula futhi ivimbele imishanguzo emdlalweni we- medullary umdlavuza wegciwane . I-metformin ibonakala iphazamisa izindlela eziyisikhombisa zokubonisa ukugqugquzela ukukhula okunjalo.
- I-Metformin ne-Nodules ye-Thyroid: I- Metformin nayo inomsebenzi wokulwa nokukhula okumelene nama-nodules we-thyroid, ukunciphisa ukukhula kwabo noma ukunciphisa usayizi wabo. Ucwaningo lubhekisele ocwaningweni oluthola ukuthi ezigulini ezinezintuthwane ezincane ze-thyroid kanye ne-insulin ukumelana, ukwelashwa nge-metformin kwaholela ekunciphiseni ubukhulu bama-nodules, kanye nokuwa kwezinga le-TSH. Olunye ucwaningo lwamuva lwabesifazane abane-insulin ukumelana nezintuthwane ze-thyroid zathola ukuthi kunciphisa okukhulu kakhulu ekutheni ubukhulu be-nodule eziguli eziphathwe nge-metformin ne-levothyroxine, ngokungafani noma izidakamizwa ezithathwe zodwa.
- Ukuguqulwa kwe-Metformin kanye ne- TSH ye-Thyroid Cancer Iziguli: Ukwelashwa kwe-Metformin kwakuhlotshaniswa njalo namazinga we-TSH ayancipha, okuphakamisa ukuthi kungaba nendima emithanjeni yamanje yamasosha omdlavuza we-thyroid okubhekiswe ekunciphiseni amazinga e-TSH ukuvimbela ukuphindaphindiwe komdlavuza we -roid. I-metformin ingaba usizo ikakhulukazi, ngoba ibonakala icindezela amazinga we-TSH, ngaphandle kokubangela i-hyperthyroidism.
- Izimo ze-Metformin ne-Thyroid ngohlobo lwe-2 lwesifo sikashukela: Kukhona ukukhula kwesilinganiso se- hypothyroidism e-type 2 yesifo se-diabetics ku-metformin therapy. I-Metformin ihlotshaniswa namazinga anciphise ama-hormone evuselela i-thyroid (TSH) ezigulini zesifo sikashukela. Kuhlobo lwesibili lwesifo sikashukela esinomdlavuza we-thyroid, ukwelashwa nge-metformin kwakuhlotshaniswa nokukhululwa okuphezulu kanye namanani okusinda ezigulini zesifo sikashukela onomdlavuza we-thyroid, kanye nemiphumela enhle kubantu abanezifo zesifo sikashukela abanomdlavuza we-thyroid ohlukile owenziwe ngezakhi zamantombazane. Abacwaningi bathi i-metformin yenza ngcono ama-hormone e-thyroid emgodini we-pituitary.
Ukucabangela Okubalulekile
Ucwaningo luye lwabonisa ukuthi ukufakelwa kwe-levothyroxine akushintshe ngokuthatha i-metformin, ngakho-ke kuphephile ukuthatha izidakamizwa ezimbili ngesikhathi esifanayo.
Nokho, inselelo yilokho ngoba i-metformin inganciphisa i-TSH ngaphandle kokuphazamisa amazinga we-T4 noma ama-T3, ingase ingabonakali isimo seqiniso segilo sohlobo lwe-2 lwesifo sikashukela esine-hypothyroidism esithatha kokubili i-metformin ne-levothyroxine. Kungase futhi kuphazamise ukucindezelwa kohlobo lwe-diabetics olunesifo somdlavuza we-thyroid futhi aludingi kuphela amazinga e-TSH acindezelayo, kodwa amazinga aphakeme ajikeleza ama-hormone e-T4 ne-T3 evikela isifo somdlavuza.
Ngokusho kwabacwaningi:
Izinga le-TSH elicindezelekile linikeza ukuqinisekiswa okungamanga noma kungase kuvuselele ukuqaliswa kwelashwa, noma i-endocrinologists inganciphisa izinga le [levothyroxine] ngezinga eliphansi eliphansi le-TSH. Abahlengikazi kufanele bacabangele umphumela we-metformin uma behumusha umsebenzi we-thyroid ukuze bagweme noma yikuphi ukwelashwa okufanele noma ukulungiswa kwesilinganiso [levothyroxine].
Ukunciphisa umthamo kungabangela izimpawu ze-hypothyroidism ukubuyela ngoba, naphezu kwe-TSH ephansi, kungenzeka ukuthi akwanele ukujikeleza i-hormone ye-thyroid ukuze unciphise izimpawu ze-hypothyroid.
Ukwengeza, emva kokuhlinzwa ukukhipha igciwane ukuze uphathe umdlavuza wegciwane, iziguli eziningi zifakwa ekwelapheni okucindezelayo, ukugcina izinga le-TSH liphansi kakhulu futhi amazinga e-hormone wegciwane aphezulu ukuvimbela umdlavuza we -roid. Kuhlobo lwe-2 lwesifo sikashukela esinesifo somdlavuza we-thyroid, futhi une-thyroidectomy ukususa isikhumba, i-TSH ephansi kakhulu ngenxa ye-metformin therapy ingasikisela isidingo somthamo we-levothyroxine. Lokhu kunciphisa emtheni, noma kunjalo, kungase kungakutholi ukucindezelwa ezingeni leselula.
Izwi kusuka
Lezi zitholakele ezintsha ezithakazelisayo ziphakamisa ukuthi kungase kube nokusetshenziswa okungenani kwe-metformin emaqenjini amaningana:
- Thayipha u-2 wesifo sikashukela ngesifo se-thyroid
- Thayipha u-2 wesifo sikashukela esingenayo igciwane lesifo
- Abantu abane-hypothyroidism abane-insulin ukumelana, isifo se-metabolic syndrome, kanye / noma ukukhuluphala
- Ukwelashwa komdlavuza we-Thyroid ku-TSH-therapy yokwelapha
Kodwa-ke, okwamanje, izazi zincoma izifundo eziningi zokwelapha ukuze zihlolisise ukusetshenziswa kwe-metformin njengengxenye yokwelashwa kwesifo se-thyroid kanye nokwenza izindlela zokwelapha ezingase zibe khona kanye nemikhombandlela.
Uma unama-hypothyroid, futhi unesifo se-insulin, kodwa ungakabi nesimo se-metformin, kungase kudingeke ukuba ube nengxoxo nodokotela wakho ngokuphathelene nokungeze ohlelweni lwakho lwezokwelapha. I-Metformin ibhekwa njengomuthi ophephile onemiphumela emibi embalwa, futhi inqunyelwe isifo se-metabolic / pre-diabetes / insulin ukumelana, futhi ingamisa ukuqhubekela phambili ukuthayipha u-2 wesifo sikashukela. Lokhu okutholakele okusha kusikisela ukuthi kungase kube nomthelela wokuvikela ku-thyroid yakho.
> Imithombo:
> Distiller LA, et al. "Thayipha u-2 wesifo sikashukela kanye ne-hypothyroidism: ithonya elikhona le-metformin therapy." I-Diabet Med 31 172-175. 2012.
> Xianghui M et al. "Ukubuyekeza: I-Metformin nesifo se-thyroid." I-Journal of Endocrinology. Ukusabalalisa ku-intanethi, ngo-14 Febhuwari 2017. Abstract / Full PDF