Noma kunjalo ayikho i-FDA evunyelwe
I-Ampligen (i-rintatolimod) ku-test anti-viral, isimiso sokuzivikela komzimba esisebenza emisebenzini iminyaka engaphezu kwengu-30. Kuye kwacwaningwa njengendlela yokwelapha ngezimo eziningi, kuhlanganise nokugula okungapheli (i-CFS noma i- ME / CFS ), i- HIV / AIDS , izinhlobo ezithile zomdlavuza , kokubili umkhuhlane wezinyoni nomkhuhlane wezingulube (H1N1) , ne- Ebola virus.
Ngo-2009 futhi futhi ngonyaka ka-2013, i-FDA inqabe i-Ampligen njengokwelashwa kwe-ME / CFS.
Bekungaba ukwelashwa kokuqala okuvunyelwe kwalesi simo kanye nokunikeza ukungena kuka-Ampligen emakethe. Naphezu kwalokhu kwehluleka, umkhiqizi uyaqhubeka ethuthuka ukuze athole lesi sidakamizwa samukelwe.
I-Ampligen isebenza kanjani?
I-Ampligen ikholelwa ukuthi isebenza ngokugxuma-ukuqala indlela emzimbeni yomzimba wakho wokulwa negciwane nokulawula amazinga ka- RNase L (into ekhona amangqamuzana akho ahlasela ama-virus), angaba phezulu kubantu abane-ME / CFS. Kuye kwaboniswa ukuvimbela ukukhula kweseli se-tumor.
U-Ampligen akabonakali ukuvimbela isistimu yomzimba. Esikhundleni salokho, bakholelwa ukuthi ushintshe indlela amasosha omzimba wakho asebenza ngayo.
Ampligen for Isifo Sokugcina Sokukhathala
Ekuvivinyweni kwemitholampilo, i-Ampligen iye yaboniswa ukuze ithuthukise ukuqonda, ukubekezela kokuzivocavoca, impilo yokwelashwa ne-neuropsychological kanye nomsebenzi jikelele kubantu abane ME / CFS; ukunciphisa umsebenzi we-HHV-6 (igciwane elikholelwa ukuthi lihlobene ne-ME / CFS), futhi kunciphise umsebenzi we-RNase L.
Ngokomkhiqizi ka-Ampligen, i-Hemispherx Biopharma Inc., inani elingaphezu kuka-40,000 lama-Ampligen lanikezwa iziguli ezingaba ngu-500 ezivivinyweni zemitholampilo emitholampilo engaphezu kuka-20 yase-US. Omunye wale miitholampilo, i-Hunter-Hopkins Center, ithi iziguli ezingu-80% zazo ziphuthumisiwe ku-Ampligen, futhi ama-50% aphuthukisiwe kakhulu.
Ngenxa yokuthi u-Ampligen okwamanje akavunyelwe noma yikuphi ukusetshenziswa e-US, imitholampilo kuphela enezimvume ezikhethekile ingamisela u-Ampligen. Kuyinto ebiza kakhulu kakhulu - njengokungaphezu kwama $ 40,000 ngonyaka! Futhi cha, umshuwalense wakho ngeke awumboze, ngoba uyahlolwa.
I-Ampligen nayo ayihlali engavunyelwanga e-European Union, kodwa ezinye iziguli lapho zingase zikwazi ukuthola lokho okuthiwa "uhlelo lokufinyelela ekuqaleni."
Ampligen Isilinganiso
I-Ampligen ilawulwa ngokulandelana (IV). Ezilingo futhi ngaphansi kwemvume evumelekile yi-FDA, iziguli ngokuvamile zithole u-400mg wesidakamizwa kabili ngesonto. U-Hunter-Hopkins uncoma okungenani izinyanga ezingu-12 zokwelashwa nezinyanga ezingu-18 ezigula kakhulu.
Ampligen Side Effects
Njenganoma imuphi umuthi, i-Ampligen ingabangela imiphumela emibi engadingeki. Imiphumela emibi engase ibe khona ihlanganisa:
- Ukufudumala okuncane,
- Ukuqina kwesifuba,
- Ukushaya kwenhliziyo okusheshayo,
- Ukukhathazeka,
- Ukuphelelwa umoya,
- Ukuzwa kushisa,
- Ukuphika,
- I-nausea,
- Izinguquko zezinga le-enzyme,
- Uhudo,
- Ukunambitha,
- Umfutho wegazi ophansi,
- Rash,
- Arrhythmias,
- Ukubalwa kwesisindo segazi eliphansi,
- Isizungu,
- Ukudideka.
Ezinye iziguli zinezimpawu ezinjenge-flu omahora ambalwa ngemva kokuthola isilinganiso somuthi. Umkhiqizi uthi lezi zivame ukuhamba ngemva kwezinyanga ezimbalwa zokwelashwa.
Imithombo:
Smith ME, et al. Amalengiso omuthi wangaphakathi. 2015 Jun 16; 162 (12): 841-50. Ukwelashwa kwe-myalgic encephalomyelitis / chronic fatigue syndrome: ukubuyekezwa okuhlelekile kwe-National Institutes of Health Pathways to Prevention Workshop.
Strayer DR, et al. PLoS One. 2012; 7 (3): e31334. I-doublebop blind, i-placebo-elawulwayo, engahleliwe, isilingo somtholampilo se-TLR-3 i-rintatolimod ezimweni ezinzima zesifo esingapheliyo sokukhathala.
Strayer DR, et al. Izifo ezithathelwanayo zomtholampilo. 1994 Jan; 18 Ukusekela 1: S88-95. Isivivinyo somtholampilo esilawulwayo nesidakamizwa se-RNA esilungisiwe, i-poly (I) .poly (C12U), e-syndrome engapheliyo yokukhathala.
I-Suhadolnik RJ, et al. In vivo. 1994 Jul-Aug; 8 (4): 599-604. Izinguquko ku-2-5A i-sythetase / RNase L yindlela yokuvimbela unqulo wesivivinyo esilweni esilawulwayo semitholampilo nge-poly (I) -poly (C12U) e-syndrome engapheliyo.