Izinkomba mayelana Nezizathu Ze-CFS
Yini ebangela ukugula okungapheli kwesifo? Umbuzo onzima! Naphezu kocwaningo oluningi, ochwepheshe abazange bakwazi ukukuchofoza nganoma yisiphi isizathu esisodwa. Abanye bakholelwa ukuthi isifo esingapheliyo sokukhathala ( ME / CFS ) singabangela izici eziningi ezihlangana ndawonye ngaphansi kwezimo ezifanele. Lezi zici zingafaka:
- Izici zofuzo
- Isistimu yezinzwa eziphakathi (CNS) nama-hormone ajwayelekile
- Igciwane noma olunye ukutheleleka
- Ukungahleleki kwesistimu yomzimba
- Izimo ezicindezelayo
- Ukuvezwa kobuhlungu
Akuwona wonke umuntu onama-ME / CFS onayo zonke lezi zinto eziqhubekayo. Kungenzeka ukuthi banezinhlanganisela zabo, ngenxa yezizathu ezithile, eziye zaholela esimweni. Ngenxa yokuthi inhlanganisela ehlukene yezici ingabangela izimpawu ezihlukahlukene kanye nezinguquko emzimbeni, ochwepheshe babonisa izigaba noma amaqembu angaphansi kwe-ME / CFS. Ekugcineni, i-subgrouping ingakusiza wena nodokotela wakho ukuthola indlela engcono yokuphatha ngayo.
Izakhi zofuzo
Ucwaningo luxhumanisa i-ME / CFS ngezakhi zofuzo ezithintekayo kwi- hypothalamic-pituitary-adrenal (HPA) axis kanye nohlelo lomzwelo oluzwelayo. I-axis ye-HPA ilawula ukulala kwakho, impendulo yokucindezeleka, nokucindezeleka.
Esicwaningweni sika-2006 eshicilelwe ku- Pharmacogenetics , abacwaningi babheka i-DNA elawula ukuthi umzimba wakho uphendukela kanjani ekudakaleni, ukulimala nokucindezeleka, futhi bathola ukuhluka okufanayo okungabikezela i-ME / CFS ngamaphesenti angu-76 ngokunemba.
I-CDC ibize lokhu "ubufakazi bokuqala bokuthembeka kwesisekelo sezinto eziphilayo zokugula okungapheli syndrome." Noma kunjalo, abacwaningi babengakwazi ukukhomba izimpawu zofuzo noma banqume ukuthi ukuhlukahluka kwathonya kanjani izimpawu.
Olunye ucwaningo lubonisa ukungalingani kwezakhi zofuzo kubantu abane-ME / CFS ezithonya ukusebenza komzimba, ukuxhumana kwamaselula, nezindlela izindlela amangqamuzana akho athola amandla.
Konke lokhu kusikisela ukuthi abanye abantu bangase bahlelwe ngokwemvelo ku-ME / CFS - ngamanye amazwi, cishe bayothola uma izimbangela ezanele zihlangana ndawonye. Isibonelo, uma umuntu obhekene nesikhathi esicindezelayo bese ehlushwa igciwane ethile noma i-toxin, bazokwakha i-ME / CFS. Kodwa umuntu onokwenza izakhi zofuzo ezahlukene, noma kunjalo, uzovela esimweni esifanayo futhi ahambe kahle.
I-CNS namaHormoni
Njengoba kushiwo ngenhla, abanye abantu abane-ME / CFS abanalo okungajwayelekile kwi-axis ye-HPA. Abacwaningi banesithakazelo ikakhulu kwezinye zamakhemikhali nama-hormone aphakathi nendawo alawulwa yi-HPA axis:
- I-Neurotransmitter iyashintsha
Ama-Neurotransmitter amakhemikhali akhuluma ngemilayezo ebuchosheni bakho. Ucwaningo luye lwabonisa ukuthi abanye abantu abane-ME / CFS banamazinga angavamile ama-neurotransmitter athile abalulekile (i- serotonin ne- dopamine ). Abacwaningi bazama ukuchaza indima lezizinto ezingavamile ezidlala ku-ME / CFS. - Ukucindezeleka kwe-hormone
Ochwepheshe bayazi amazinga we-hormone yokucindezeleka i-cortisol aphansi kweziguli ze-ME / CFS, futhi bakholelwa ukuthi lokhu kungenza kube nzima ukubhekana nokucindezeleka - kungaba ngokomzimba (njengokutheleleka noma ukuzama) noma ingqondo. Ukushintshwa kwe-Cortisol kusiza abanye, kodwa hhayi bonke, iziguli ze-ME / CFS. Esifundweni sika-2008, abesifazane abaneMe / CFS babe namazinga aphansi e-cortisol ngesikhathi amadoda angenawo ama-ME / CFS engakwenzi, angasiza ekuchazeni ukuthi kungani isimo sivame kakhulu kubantu besifazane.
- Izinga le-circadian eliphazamisekile
Iwashi lakho langaphakathi (ingxenye ye-HPA axis) ilawula umjikelezo wakho wokulala. Ubufakazi bubonisa ukuthi kwabanye abantu abane ME / CFS leli hanga lilahliwe, mhlawumbe ngomcimbi wengqondo noma ngokomzimba, futhi umzimba awukwazi ukuthola isigqi esifanele esasungulwa kabusha. Abantu abanenkinga kubonakala sengathi bachitha isikhathi esiningi esimweni sokuhamba ngokushesha (REM) sokulala, okuyilapho uphupha khona. Abantu kulesi sigaba esincane se-ME / CFS bathola usizo oluthe xaxa kusuka emithini yokulala kunabantu abangezinye izingxenye, ngokusho kochwepheshe.
Izifo
Izimbonakaliso eziningi ze- ME / CFS zifana nokugula okubangelwa igciwane lesandulela ngculaza, ngakho-ke ucwaningo oluningi luye lwagxila ekubambeni kwegciwane lesandulela ngculaza noma lesandulela ngculaza.
Abacwaningi baye bahlola imibono emithathu ephathelene nokutheleleka, nakuba kungekho okuye kwafakazelwa:
- Igciwane noma amabhaktheriya ahlasela umzimba futhi awonakele isimiso somzimba. Umonakalo uyaqhubeka nokudala izimpawu ezifana nezifo ngisho nangemva kokuphela kwegciwane noma amabhaktheriya.
- Ngemuva kokutheleleka, isenzo esingavamile samasosha omzimba senza igciwane elingeke lisebenze ukuze liphinde lisebenze.
- Ukusabela ngokomzimba ezifweni ezibangelwa amagciwane kwenzeka kubantu abathintekayo.
Ngenkathi kungekhona wonke umuntu onama-ME / CFS obonisa izimpawu zokutheleleka, abaningi benza. Izicucu eziningana zobufakazi zisekela inkolelo yokuthi amanye ama-ME / CFS abangelwa okungenani ngengxenye yegciwane:
- Ukungena kwe-Enterovirus
Esifundweni sika-2007, abantu abane-ME / CFS babephindwe kane amathuba kunabantu abanempilo ukuthi babe nobufakazi bama- enteroviruses ezintanjeni zabo zesisu. I-enteroviruses ibangela ukutheleleka kwesisu, futhi izimpawu ze-ME / CFS ziqala ngemva kwalolu hlobo lokugula. - Rnase L
Umzimba wakho usebenzisa i-enzyme Rnase L ukuze ubulale amagciwane ahlasela amangqamuzana akho, futhi iziguli ze-ME / CFS zivame ukuqhuba umsebenzi omkhulu we-Rnase L. - Umbulali wemvelo (NK) Amaseli kanye namaseli T
Ama-NK & T amasosha omzimba wakho ahlasela amangqamuzana aphethwe yigciwane, futhi abantu abane-ME / CFS bavame ukukhubazeka imisebenzi ye-NK ne-T kanye nezinombolo, okubonisa ukuthi ukuzivikela okungasetshenziswa isikhathi eside kungase kubangele futhi kubangele. - Ama-Antibodies
Abantu abane-ME / CFS ngokuvamile banamazinga aphezulu e-antibodies ezinhlobonhlobo eziningi ezibangelwa ukutheleleka ezibangela ukukhathala nezinye izimpawu ze-ME / CFS. Lezi zinhlobo zihlanganisa lezo ezibangelwa i-candida (imvubelo), uhlobo lwe-herpesvirus yomuntu (i-HHV-6), isishukela, i-parvovirus ne- Epstein-Barr . Abacwaningi abakwazi ukukhombisa ukuthi noma yikuphi kwalokhu kuyimbangela enkulu ye-ME / CFS. - Ukuqala kokugula ngemuva
Amaphesenti angama-80 we-ME / CFS amacala aqala ngokuzumayo ngemva kwesimo esifana nesifo. - Ukuqubuka kwamaCluster
Ngenkathi i-CDC ingakaqinisekisi ukuqubuka kwamagatsha amaningi, imibiko yabantu abaningi endaweni efanayo, endaweni yokusebenzela, kanye nomphakathi okuthuthukisa i-ME / CFS ngesikhathi esifanayo ayitholakali.
Abanye abacwaningi basikisela ukuthi izinguquko kuma-bacteria angenalutho emathunjini angadlala indima ekuthuthukiseni i-ME / CFS.
Noma kunjalo, ubufakazi obubonakala bubonakala buphikisana ne-theory-cause theory. I-ME / CFS ayibonakali ekusakazeni ngokuqukethwe okuqondile, abantu abakhona abakatholakali, futhi-naphezu kwezifundo ezenzelwe kahle - abacwaningi abakwazi ukuxhumanisa i-ME / CFS nganoma yiziphi izifo ezithile.
Inothi Mayelana ne-XMRV
Ngo-2009, abacwaningi be-Whittemore Peterson Institute (WPI) bathicilele ucwaningo emagazini weSayensi owaphakamisa ukuxhumana phakathi kwe-XMRV, i-retrovirus esanda kutholakala, ne-ME / CFS. Bathole i-XMRV cishe ngamaphesenti angama-67% we-sampuli yegazi kusuka ku-ME / CFS iziguli. Bawutholile futhi ku-3% wokulawula okunempilo.
Kodwa-ke, izifundo ezalandela zahluleka ukuqinisekisa isixhumanisi, kuhlanganise nesifundo esikhulu esibandakanya umcwaningi oyinhloko we-WPI. Ezinye izifundo ziphakanyisiwe izindlela zokungcola okungenzeka zenze ama-positive positives ekufundeni kwangempela. Ngasekupheleni kuka-2011, inkolelo ye-XMRV yayisonke-kodwa ishiywe.
Amasosha omzimba
Ucwaningo oluthile luye lwabonisa ukungalungi kuma-immune systems yabantu abane-ME / CFS, kodwa abacwaningi abazange bathole iphethini elingavamile lokungajwayelekile. Phakathi kwezinto ezivame ukwedlula zonke izifo zomzimba kanye nesistimu yomzimba ongasebenzi ngokweqile.
Ezinye izifundo ziye zabika ukuthi iningi leziguli ze-ME / CFS zithinta izinto ezibandakanya impova, ukudla kanye nezinsimbi ezifana ne-nickel ne-mercury.
Lokhu kuholele ekufundiseni ukuthi izifo ezithile zingase zenze uchungechunge lwezinto ezingavamile zokuzivikela eziholela ku-ME / CFS. Enye inkolelo yukuthi ukuphefumula, ukucindezeleka kanye nokutheleleka kungahlanganisa ukuchitha ikhemikhali ebizwa ngokuthi i-adenosine triphosphate (ATP), egcina amandla emangqamuzaneni. Ezinye iziguli ze-ME / CFS zibonisa ubufakazi bokuthi wehlile ukukhiqizwa kwe-ATP.
Ezinye iziguli ze-ME / CFS zinamazinga aphezulu okuthiwa yi- cytokines , okuyizinto ezithandwa ososayensi ezingabangela izimpawu ze-ME / CFS, kuhlanganise nokukhathala kanye nama-muscle aches. Ucwaningo oluningi lubike ukungalingani kweT cell kubantu abane-ME / CFS, kodwa ezinye izifundo aziqinisekisile ukuthi i-T cell ne-cytokine ayiphutha.
Ukukhathala kwesifo sengqondo kubonakala sengathi kunezici ezimbalwa ezifanayo nezifo ezizimele ezifana ne- lupus noma i- multiple sclerosis , lapho amasosha omzimba ahlasela ngokungaziphathi izingxenye zomzimba ezinempilo. Ucwaningo olusanda lukhula lubonisa ukuthi i-ME / CFS ingahle ikwazi ukuzimela.
Ukucindezeleka
Abacwaningi bakholelwa ukuthi ukwakheka kwakho kwengqondo, ubuntu kanye nesimo sezenhlalakahle kungaba nomthelela ukuthi uzobe uthuthukisa i-ME / CFS, kodwa bengakayiqondi ngokugcwele ubuhlobo obuyinkimbinkimbi phakathi kwabo.
Yize lezi zici cishe zingesiyimbangela eyinhloko ye-ME / CFS, kungenzeka ukuthi iyoba nendima ekwenzeni ube namandla.
Qaphela: I-ME / CFS ayithathwa njengokugula okuyisisekelo kwengqondo, futhi ukungena nge-ME / CFS kusho ukuthi umuntu unobuthakathaka ngokwengqondo noma akakwazi ukubhekana nezinto. Nakuba ngezinye izikhathi kuhlotshaniswa nokucindezeleka komtholampilo, i-ME / CFS yinkinga ehlukile.
Amakhemikhali / Ubuthi
Enkampanini eyodwa, ukukhathala okungapheli nobuhlungu kuhlotshaniswa nokuvezwa kwamakhemikhali ahlukahlukene kanye ne-toxic. Lezi zingabandakanya izixazululo, izibulala-zinambuzane noma izinsimbi ezisindayo. Kodwa-ke, ngoba iningi lethu liye lahlulwa kulezi zinhlobo zamakhemikhali ngesikhathi esithile, kunzima ukulandelela ukuthi yiziphi ezingase zidale izinkinga. Isimo esibizwa ngokuthi i- multiple chemical sensitivity (MCS) senza izibonakaliso eziningi ezifana ne-ME / CFS, futhi lezi zinsuku zikholelwa ukuthi ziyizimo ezixubile .
Imithombo:
Izikhungo zokuLawula nokuvimbela izifo zika-2006. "Izinkinga Ezingenzeka"
UDkt JKS Chia. I-Copyright 2005 Co-Cure. Wonke Amalungelo Agodliwe. "Indima ye-enterovirus e-chronic fatigue syndrome"
Kaiser J. Science. 2011 Jan 7; 331 (6013): 17. Isifo sokuphelelwa yisikhathi esingapheli. Izifundo zikhomba ukungcola okungenzeka ku-XMRV.
I-Lombardi VC, et al. Isayensi. 2009 Okthoba 23; 326 (5952): 585-9. Ukutholwa kwe-retrovirus esithathelwanayo, i-XMRV, emaqenjini egazi abantu abane-syndrome engapheliyo
Nater UM, et al. I-Journal ye-endocrinology yemitholampilo kanye ne-metabolism. 2008 Mar; 93 (3): 703-9. Ukunqunywa kwe-cortisol yokusabalala ekuseni ekuseni ekutadisheni kwabantu ngesifo esingapheli syndrome kanye nokulawulwa kahle.
Simmons G, futhi. al. Isayensi. 2011 Nov 11; 334 (6057): 814-7. Ukuhluleka ukuqinisekisa i-XMRV / i-MLV egazini leziguli ezine-syndrome ezingapheliyo: isifundo se-multi-laboratory.
Vernon, S. Pharmacogenomics, ngo-Ephreli 2006; vol 7: iphe 345-354. Inselele yokuhlanganisa idatha ehluke kakhulu yokuqukethwe: idatha ye-epidemiological, imitholampilo kanye nelabhoratori eqoqwe ngesikhathi sokuhlolwa kwesibhedlela ngesifo esingapheliyo sokukhathala.