Ingabe kukhona ukuxhumana phakathi komdlavuza we-estrogen nomdlavuza? Siyazi ukuthi kukhona umehluko omkhulu phakathi komdlavuza wamaphaphu emdlalweni wesifazane nomdlavuza emadodeni. Siphinde sazi ukuthi amangqamuzana omdlavuza wamaphaphu anemitholampilo ye-estrogen, okungukuthi, izindawo ezingaphezulu kweseli ezingabopha i-estrogen. Nakuba ulwazi lwethu lungapheli ngalesi sikhathi, lokhu kungasho ukuthini kwabesifazane abanomdlavuza wamaphaphu namuhla, noma engozini yomdlavuza wamaphaphu esikhathini esizayo?
Ngaphambi kokukhuluma ngezifundo, kuyasiza ukuchaza ukuthi kungani eminye imiphumela ingase idideke kakhulu. Kukhona izindlela eziningana ezahlukene (izindlela) lapho i-estrogen idlala indima emdlalweni wamaphaphu. Kubalulekile ukuveza ukuthi eziningi zalezi zifundo zikhuluma ngezinkinga ezimbili ezihlukene kakhulu. Enye ingebangela-ingabe izinga eliphezulu noma eliphansi le-estrogen linomphumela wokuthi ngabe umuntu uzokwakha umdlavuza wamaphaphu kuqala? Enye inguquko-ingabe i-estrogen ingabangela umdlavuza wamaphaphu osevele ukhona ukuze ukhule ngokushesha noma uhambe kancane?
Umlando Wokuzala
Yize siqonda ukuthi umdlavuza webele uvame kakhulu kubantu besifazane abaqala ukuba nezinkathi ezincane, izifundo azizange zithole ukuthi kunjalo nangomdlavuza wamaphaphu. Umdlavuza we-Lung wacatshangwa ukuthi awuncane kakhulu kubantu besifazane abaye baba nezingane ezingaphezu kwalabo ababenabantwana abancane noma abakho, ikakhulukazi kwabesifazane abangazange baphuze.
Ukuhlaziywa kwamuva kwamathekisthi kuze kube manje kubonisa ukuthi umdlavuza ongasona omncane wesifo samaphaphu , kodwa hhayi umdlavuza omncane wamaseli wamaphaphu , ungase ungajwayelekile kangako kwabesifazane ababenabantwana abaningi. Ucwaningo oluthile lwathola ukuthi, ngokungafani nomdlavuza webele, ingozi yomdlavuza wamaphaphu yayingaphansi lapho abesifazane bebeletha esikhathini esizayo.
(Uma kuqhathaniswa, umdlavuza webele usengozini yokunciphisa ngokuba nomntwana wokuqala ngaphambi kokuphila (ngaphambi kuka-30) kodwa ingozi yomdlavuza wamaphaphu iyancipha kancane ngokuba nengane kamuva ekuphileni.)
Ucwaningo lwamuva lubonisa ukuthi abesifazane abanezimpawu zabo zombili ama-ovari asuswe ("ukukhishwa kwesikhashana kokuhlinzwa") kungaba nengozi ephakeme yokuthuthukisa umdlavuza wamaphaphu. Ezinye izifundo ziye zabonisa ukuhlangana okuncane phakathi kokuya esikhathini sokuqala nokuthuthukiswa komdlavuza wamaphaphu.
Izifundo zezilwane
Ucwaningo olulodwa ngamagundane lwaphakamisa ukuthi i-estrogen ingakhuthaza ukukhula kwamanqamu emaphaphu. Kulolu cwaningo, izimpumputhekazi ezinama-ovari zathuthukisa ama-tumors amaningi kakhulu kunezigundane zamasifazane ezazisuswa ama-ovaries. Ngaphezu kwalokho, lapho amagundane angenawo amaqanda aphethwe i-estrogen, izicubu zabo zakhula ngokushesha kunamagundane angaphathwa nge-estrogen.
I-Hormone Alternative Therapy
I-hormone ye-substitution therapy , noma i-HRT (i-estrogen ne-progesterone) yezimpawu ze-menopausal ingandisa ingozi yokufa ngumdlavuza wamaphaphu, ikakhulukazi kubantu ababhema. Ekuhloleni kwabesifazane abangu-16 000 abanomdlavuza wamaphaphu ongewona omncane, labo abasebenzisa ukwelapha okushintshe ama-hormone babe ngamaphesenti angama-60 amathuba okufa ngesifo. Kubalulekile ukuqaphela ukuthi kulolu cwaningo, inhlanganisela ye-HRT yandisa ingozi yokufa komdlavuza wamaphaphu uma isivele isenayo, kodwa hhayi ithuba lokuthi omunye angakha umdlavuza wamaphaphu.
Ngokuvamile, ukuhlola okubheka izinhlanganisela njengesibangelwa umdlavuza wamaphaphu kuye kwaxubaniswa, kanti ezinye zibonisa ukwanda, ezinye azibonisi ukuhlangana, kanti ezinye izifundo ezintsha zibonisa ukwehla kwengozi yomdlavuza wamaphaphu.
Ukubuyekezwa kwe-PLoS yakamuva kubheka indima ye-estrogen therapy (ngaphandle kwe-progesterone) yodwa engozini yomdlavuza wamaphaphu kwabesifazane njengengxenye yokucwaninga kwe-California Teachers. Kulesi sifundo, kwakungekho inhlangano (akukho ukwanda noma ukwehla) phakathi kokusetshenziswa kokwelashwa okuhlanganisiwe (estrogen plus progesterone) kanye nengozi yomdlavuza wamaphaphu. Kodwa-ke, kwabesifazane abasebenzisa ukwelashwa kwe-estrogen kuphela, abasebenzisi bokuqala be-estrogen abanesikhathi esifushane sokusetshenziswa (eminyakeni engaphansi kwengu-5) babe nengozi ephansi yokufa ngumdlavuza wamaphaphu (cishe amaphesenti angu-46), nabasebenzisi bamuva be-estrogen benesikhathi eside isikhathi sokusetshenziswa (iminyaka engaphezu kwengu-15) nayo yayinengozi encane yokufa lesi sifo (cishe amaphesenti angu-40).
Ucwaningo oluthile lwathola umdlavuza omncane wamapayipi phakathi kwabesifazane ababesebenzisa amaphilisi okubeletha ngomlomo.
I-Phytoestrogens
Ukudla kwama-estrogen ase-plant (based phytoestrogens), afana nalawo atholakala ku-soy, kuye kwahlolwa ngezifundo ezimbalwa ngomdlavuza wamaphaphu. Kwezinye zazo, kubonakala sengathi abesifazane abasebenzisa ukudla okuphakeme kakhulu e-phytoestrogens banomphumela ophansi wesifo somdlavuza wamaphaphu, ikakhulukazi kwabesifazane abangakaze babheme.
Ngaphansi
Njengoba umdlavuza wamaphaphu, ngezindlela eziningi, isifo esihlukile kubesifazane, kubalulekile ukubheka indima engenzeka ye-estrogen. Kodwa njengoba kuphawuliwe ngenhla, lokho esikwaziyo mayelana nomdlavuza we-estrogen nesifo samaphaphu kusekuqaleni kwezinyathelo.
Ngayiphi inqubo noma imithi, kubaluleke kakhulu ukukala izinzuzo zokwelashwa ngokumelene nezingozi ezingenzeka. Isibonelo, uma udokotela wakho uncoma ukuthi ama-ovaries akho asuswe ngenxa yezizathu ezithile, inzuzo yenkambiso ingase ikhulu kakhulu ukwanda okungenzeka kwengozi yomdlavuza wamaphaphu.
Okwamanje, lezi zifundo ziyisikhumbuzo esihle sokukhuluma nodokotela wakho uma ususelwa ekwelashweni okwe-hormone, ikakhulukazi uma ubhema, futhi ubuza imibuzo. Udinga ukuthatha imithi? Zikhona ezinye izindlela? Zikhona yini izinzuzo ezihamba ngaphezu kweengozi engaba khona yokufa okuphezulu kusuka emdlalweni wamaphaphu (noma umdlavuza webele)?
Encwadini yokugcina, ukuqonda ukuthi amangqamuzana omdlavuza wamaphaphu anemitholampilo ye-estrogen ivula iminyango yokuthi mhlawumbe eminye yemithi esetshenziswa ngokujwayelekile ngomdlavuza wesifuba ingaba nomthelela ekwelapheni umdlavuza wamaphaphu esikhathini esizayo.
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