Isizathu Sokuba Sinamandla Amandla Nendlela Yokulwa Nayo
Kukhona okuthiwa i- fibromyalgia (i-FMS) ne- syndrome yokukhathala okungapheli ( ME / CFS ) efana nokuntuleka kwamandla. Lokhu kuhluke ekukhathaleni noma ukungabi nesisusa esingaba nokucindezeleka. Singafuna ukwenza okuthile okwamanje asikwazi ukukwenza.
Okokuqala, akufani nokukhathala nokudinga ukulala. Kungaphezulu kwe-bone-tired, ayikwazi ukuhambisa umuzwa womzimba.
Uma ngabe uke wakwazi ukufika endaweni ongakwazi ukuyenza, kungakhathaliseki ukuthi ufuna kangakanani, yilokho esikhuluma ngakho. Uma uke waphuma e-anesthesia enezitho zakho ezithwala kakhulu ukuphakamisa, uthola. Ungase ufune ukulala, kodwa wena udinga ukuphumula imisipha yakho ngaphambi kokwenza noma yini enye.
Ngenkathi i-FMS ne-ME / CFS, noma kunjalo, ukungabi namandla kwamandla kungashaya ngokuzumayo futhi kuhlale isikhathi eside, kungakhathaliseki ukuthi siphumula kangakanani. Kungenzeka phakathi nohambo lokuthenga, emsebenzini, noma imizuzu eyishumi emva kokuphuma embhedeni. Kungase futhi kube khona into yokuqala ekuseni bese ugcine ungakhuphuki nhlobo.
Asiqondi ngokugcwele lesi sigameko noma ukuthi kungani siyingxenye yalezi zifo, kodwa ucwaningo luveza ukuthi okungenani ngeyingxenye, ngenxa yamazinga aphansi okuthiwa i-adenosine triphosphate, noma i-ATP.
Kuyini i-Adenosine Triphosphate?
I-ATP igcina amandla emzimbeni wakho.
Izazi ze-biologist ngokuvamile zibiza ngokuthi "imali yokuphila yamandla." Umthombo omkhulu wamandla kuwo wonke amaseli aphilayo. Yilokho amandla okudla kwakho aguqulwa abe ngukuthi angakwazi ukwenza zonke izinqubo zomzimba wakho.
I-ATP ikhiqizwa yi- mitochondria emaseli akho. Amaseli akho adinga ukuthi asebenze, imisipha yakho idinga ukuthi inkontileka, konke okusemzimbeni wakho kuyayidinga ukuze wenze ngendlela efanele.
I-adenosine yenzeka ngokwemvelo emzimbeni wakho, futhi, phakathi kwezinye izinto, ihambisana nokulawulwa kwegazi ukuya kwezinye izitho zakho. Uma kuziwa ku-ATP, noma kunjalo, yiyona ingxenye ye-triphosphate ebaluleke kakhulu.
Ukwakha i-ATP, i-adenosine ijoyina amaqembu amathathu ama-phosphates. Uma amandla adingekayo endaweni ethile futhi i-ATP ithunyelwa, enye yalezi phosphates iphuliwe, ikhulula amandla. Khona-ke umzimba wakho ushintsha i-phosphate ukuze uphinde udale i-ATP. Kuyinto inqubo engapheli yokubuyisela kabusha.
Lapho izakhiwo zokwakha ze-ATP zingatholakali emzimbeni wakho noma into ephazamisa inqubo yokuvuselela, amazinga we-ATP angase abe phansi futhi akhombise ukuntuleka kwamandla.
Ukuntuleka kwe-ATP ku-Fibromyalgia
Asinayo ithoni yocwaningo ngendima ye-ATP ku-FMS, futhi izifundo esinazo zincane kakhulu. Ngenhlanhla, kuhle kakhulu ukuphakamisa ukuthi amazinga we-ATP aphansi kule nkinga.
Ucwaningo lwaseYurophu olushicilelwe ngo-2013 lwabonisa ukuhlanganiswa phakathi kokunciphisa amandla emisipha ezandleni nasezinyaweni ku-FMS nokugxila okuncane kakhulu kwe-ATP ne-phosphocreatine, efana nengxowa ye-phosphate eyenziwa ngumzimba wakho ukugcina leyo nqubo yokuvuselela iyaqhubeka njengoba ishisa amandla .
Umsebenzi wangaphambili wathola amazinga we-ATP aphansi kakhulu kuma-platelet wabathintekayo abane-FMS kanye nezinye izinto ezingavamile ezibonisa ukuthi umzimba awukwazanga ukulondoloza inani elifanayo le-ATP.
Ngakho-ke ngenkathi umsebenzi womsebenzi ubonakala ubona ukuntuleka, futhi lokho kubhekwa kuthatha indima ekungabikho kwamandla, yilokho konke esingakusho ngakho manje.
Ukuntuleka kwe-ATP ku-ME / CFS
Ku-ME / CFS, i-ATP ithole ukunakwa okungaphezulu kwabacwaningi, mhlawumbe ngenxa yokuthi ukungabi namandla kunesici esivela ku-ME / CFS kune-FMS, lapho kugxile khona ubuhlungu.
Ucwaningo oluncane lwe-ME / CFS olubheka umsebenzi we-mitochondrial kumaseli lisekele inkolelo ekhulayo yokuthi izinyathelo eziphansi zokukhiqiza ze-ATP zisuka ekusebenziseni okungahambi kahle kwe-mitochondrial, okusho ukuthi izingqimba zokwakha zamaseli azisebenzi kahle.
Esinye sezibonakaliso eziphawulekayo ze-ME / CFS yi -malaise e-post-exertional , okuyisimo esingavamile nokugqamile ngokwezimpawu ngemuva kokusebenza. Inani lokuzikhandla lithatha ukuhlukahluka komuntu, kodwa kubashiya abakwazi ukwenza umsebenzi ofanayo ngosuku olulandelayo, okuyinto engavamile futhi eyingqayizivele kule sifo.
Iphepha le-2015 lixhumanisa ama-malaise emva kokucindezela amazinga aphansi a-ATP ngenxa ye-adenosine engenele, ekhombisa ukuthi isikhathi sokuphumula sesikhathi eside sikhona ngoba umzimba kufanele ubambe kuqala ku-adenosine, bese ku-ATP.
Isihloko sokubuyekezwa eshicilelwe ngo-2014 sisekela lesi sizathu, nabacwaningi baxhuma iziphambeko ekukhiqizeni kwe-ATP hhayi nje kuphela nge-malaise yokulandela, kodwa kungenzeka ukuthi ukuqala kwalesi sifo ngokwaso kanye nokungafani okuhlukahlukene okuhambisana nokuhambisana nalo. Abalobi baleli phepha baphinde bakhombise ukuthi ukukhiqizwa kwe-ATP ephansi eM ME / CFS kungaholela ekuziphatheni komzimba ngefuthe ekufeni kwamaseli.
Ukwelapha ukwehluleka kwe-ATP
Imithi yokwelapha eyenziwa ngokujwayelekile kulezi zifo ayikwazi ukubhekana nokukhubazeka komzimba we-mitochondrial noma ukwehluleka kwe-ATP. Kodwa-ke, abanye odokotela babika impumelelo ngezingxenye ezithengiswayo ezikholelwa ukuthuthukisa lezi zinkinga eziyinhloko. Eminye yalezi zithako zinezinhlelo zokucwaninga okungenani ubufakazi bokusebenza kwazo.
Cishe uzwile nge- coenzyme Q10 (CoQ10) , eyenzeka ngokwemvelo emzimbeni wakho futhi ungathathwa njengesengezo. Kuyaziwa phakathi kwabantu abane-FMS, ME / CFS, nezinye izimo eziningi, kanye nempilo ejwayelekile. Ngokwengxenye, kungenxa yokuthi umzimba wakho udinga i-CoQ10 ukwenza i-ATP.
Ucwaningo oluningana olubandakanya i-FMS kanye / noma i-ME / CFS lixhumanisa amazinga aphansi we-ATP ne-CoQ10. Ucwaningo oluthile luphinde luphakamisa ukuthi izakhi ze-CoQ10 zenza ngcono amandla kulezi zimo. Izindleko ze-CoQ10 zingase:
- ngcono amandla
- ukunciphisa i-malaise e-post-exertional
- ukunciphisa ukukhathala
- kunciphisa ukukhulisa ubuhlungu (hyperalgesia) ye-FMS
Ezinye izithako ngezinye izikhathi eziphakanyiswa ukukhubazeka kwe-mitochondrial zifaka:
- i-carnitine
- ukudala
- D-Ribose
- i-magnesium
- i-niacinamide (i-vitamin B3)
Udokotela wakho angakwazi ukuphakamisa ezinye izindlela zokwelapha ukukhulisa amandla akho ngokuphakamisa amazinga we-ATP.
Khumbula ukuthi ngisho nezinto ezingokwemvelo zingaba nemiphumela emibi kanye nokusebenzisana okubi nezinye izinto ozithathayo. Qinisekisa ukuthi ukhuluma nodokotela wakho mayelana nanoma yiziphi izifo ozithandayo ngaphambi kokuba uqale, futhi qinisekisa ukuthi wazi ukuthi ungayiqala kanjani ngokuphepha uhlelo lomnikelo .
> Imithombo:
> Gerdle B, Forsgren MF, uBangtsson A, et al. Ukunciphisa ama-muscular concentrations we-ATP kanye ne-PCR emidlalweni ye-quadriceps yeziguli ze-fibromyalgia-Ucwaningo lwe-31P-MRS. Umagazini weYurophu wezinhlungu. 2013 Sep; 17 (8): 1205-15.
> Lengert N, Drossel B. Kokuhlaziywa kwe-silico kokungabekezelelani ngokweqile ku-myalgic encephalomyelitis / chronic fatigue syndrome. I-chemical chemistry. 2015 Jul; 202: 21-31.
> UMorris G, u-Anderston G, uBerk M, uMaes M. Coenzyme Q10 ukuphazamiseka kwezifo zezokwelapha kanye neuropsychiatric: imiphumela engaba khona kanye nemithelela yokwelapha. I-neurobiology ye-molecular. 2013 Dec; 48 (3): 883-903.
> Morris G, Berk M, Galecki P, Maes M. Indima ekhulayo yokuzimela e-myalgic encephalomyelitis / chronic fatigue syndrome (ME / cfs). I-neurobiology ye-molecular. 2014, 49 (2): 741-56.
> Morris G, Maes M. Izidakamizwa ze-Mitochondrial ku-myalgic encephalomyelitis / chronic tiredness syndrome echazwe ngezindlela ezicindezelayo zokuzivivinya ngokuzivikela emzimbeni, ezinokwenziwa kwe-oxidative kanye ne-nitrosative. Izifo zobuchopho zethambo. 2014 Mar; 29 (1): 19-36.