I-Xolair (i-omalizumab) iboniswe ukunciphisa imvamisa yokuhlaselwa kwesifo se- asthma ngokulinganisela kuya kwi-asthmatics enzima, futhi yehlisa noma isuse isidingo seminye imithi ye-asthma .
Ingabe Ngizozuza Nge-Xolair?
Ezinye iziguli ezine- asthma ezigulayo zenza i- IgE eningi kakhulu engabangela ukuwohloka kwezimpawu ze-asthma ezifana nalezi:
Ngokuvamile, ungazuza ku-Xolair uma unayo:
- I-asthma ephikisanayo ephikisanayo noma eqhubekayo
- Ukuzwela ku-allergen kanye nokuhlolwa okungavamile kokungezwani komzimba njenge-RAST
- Ayitholanga impendulo enhle ku-steroid engatholakali njengo- Flovent noma i-steroid engatholakali kanye ne-agonist esebenza isikhathi eside njengo- Advair .
Ukwengeza, ezinye iziguli ezine-asthma ezisebenzayo ezingakwazi ukushintsha indawo yazo yomsebenzi zingase zithole ukwelashwa nge-Xolair. Abanye abatshuwalense abafana ne-Aetna badinga ukuhlangabezana nemigomo ethile ngaphambi kokuvuma ukukhokhelwa kwe-Xolair ekuqaleni nokusetshenziswa kwayo okuqhubekayo.
Isebenza kanjani?
I-Xolair isebenza emazingeni ahlukahlukene ahlobene ne- asthma pathophysiology yakho kuhlanganisa:
- IgE
- Amaseli amancane
- Basophils
Ngezenzo zalo, amazinga we-IgE anciphisa kanye nomsebenzi we-basophil kanye namaseli amancane. Umphumela wancipha ukuvuvukala kanye nokungahambi kahle kwezindiza okubangelwa ukuthuthukiswa komtholampilo okukhulunywe ngaphambilini.
Ubani Ongathatha I-Xolair?
Ungasebenzisa i-Xolair uma uneminyaka engu-12 ubudala noma ngaphezulu.
I-Xolair iphathwe kanjani?
Isilinganiso sakho se-Xolair (omalizumab) sisekelwe ku:
- Isisindo
- Izinga le-IgE
Kuye ngesisindo sakho ne-IgE level, uzothola umjovo ongaphansi kwesikhumba (njalo ngaphansi kwesikhumba) njalo emavikini amabili kuya kwangu-4. Udinga ukwamukela izijovo okungenani amasonto angu-12 ukuze ubone ukuthi i-Xolair iyasebenza yini kuwe.
Uma udinga ukumisa i-Xolair ngenxa yemiphumela emibi noma esinye isizathu, imiphumela yezokwelapha izoqala ukuguga futhi izongena ngokuphelele ezinyangeni ezingu-6. Azikho izinzuzo ezingunaphakade zokuthola izijovo.
Ngenxa yengozi ye-anaphylaxis, uzothola ama-Xolair injini ehhovisi lakho odokotela futhi kuzodingeka uhlale isikhathi esingamahora amabili ukuze uqiniseke ukuthi awukwazi ukuphendula. Udokotela wakho angase futhi akunikeze futhi akufundise nge- EpiPen noma i-epinephrine injector okufanele uyisebenzise uma uthuthukisa izimpawu ze-anaphylaxis ngaphandle kwehhovisi.
Imiphumela emibi
Emiphakathini yezokwelapha ukuthola i-Xolair evunywe yi-FDA, kubonakala sengathi iphephile kakhulu. I-Xolair inikezwe kubantu abadala nabangaphezu kuka-2000 abangaphezu kuka-2000 abaneminyaka engaphezu kwengu-12 ubudala. Kusukela ngoJanuwari 2010, lokhu kwahlanganisa iziguli ezingaphezu kuka-1600 izimo eziphuthumayo zisebenzisa i-Xolair ngezinyanga ezingaphezu kwezi-6 neziguli ezingaphezu kuka-550 zisebenzisa i-Xolair unyaka noma ngaphezulu.
Imiphumela emibi evamile yenzeke ngokulinganayo kokubili iziguli ezithatha i-Xolair nalabo abathatha indawo ye-placebo. Kukhona nemiphumela eminingi engaba yingozi kakhulu okufanele umuntu ayenayo kokubili ngaphambi kokuqala ukwelashwa nge-Xolair futhi uziqaphele ngokucophelela ngomhlinzeki wakho wokunakekelwa kwe-asthma.
Ngenhlanhla, imiphumela emibi kakhulu iyabonakala engaphansi kuka-1% weziguli eziphathwe nge-Xolair.
Ulwazi lwezokuphepha lwe-Xolair lubandakanya isilumkiso esibonakalayo se-Black Box Warning esihlobene ne-anaphylaxis nesinye isixwayiso esiphathelene nomdlavuza .
Ingabe i-Xolair iphephile?
Iziguli eziningi zivame ukubuza imibuzo ngokuthi ngabe ukwelashwa okuthile kuphephile noma cha. Njengoba zonke izidakamizwa zinemiphumela emibi, lo mbuzo uphelela ngempela ukuthi wena nodokotela wakho bacabanga ukuthi imiphumela engaba khona ye-Xolair inkulu noma ingaphansi kunenzuzo yakho. Wena nodokotela wakho kufanele nixoxisane ngezingozi nezinzuzo ngaphambi kokwenza isinqumo.
Kubiza malini?
I-Xolair iyabiza kakhulu, kusukela ku-$ 500 kuya ku-$ 2000 ngenyanga. Khuluma nodokotela wakho mayelana nokuthola umshuwalense wokuthola le nqubo.
Imithombo:
I-Xolair Web Site. Ulwazi lwe-Xolair lokubhala
Barnes PJ. I-Anti IgE Therapy. www.UpToDate.com