Ukuhamba, ibhalansi, namakhono amakhono kakhulu abathintekayo
I-progressive multiple sclerosis eyinhloko (PPMS) ithinta abaningi kubantu abayisishiyagalombili abaphila ne-multiple sclerosis. Kuzo izinhlobo ezihlukahlukene zesifo , i-PPMS ibhekwa njengesihluku.
Indlela i-PPMS ehluke ngayo kwezinye izinhlobo zama-MS
Ifomu elivame kakhulu, elibizwa ngokuthi i -MS-revering-remitting MS (RRMS) , libhekene nokuhlaselwa okumangalisayo okulandelwa izikhathi zokukhululwa lapho lesi sifo singaqhubeki khona.
Uma ithuthuka, umuntu kuthiwa unenqubekela phambili yesibili (i-SPMS) .
I-PPMS, ngokuphambene, iyaqhubeka kusukela ekuqaleni. Umuntu otholwe nge-PPMS akanalo ama-flares ajwayelekile noma aphinde abuyele ehambisana ne-RRMS noma i-SPMS. Esikhundleni salokho, izimpawu zivela kancane kancane futhi aziphenduli.
Njengezinye izinhlobo ze-multiple sclerosis, inkambo ye-PPMS iyashintsha kakhulu, ithinta umuntu ngamunye ngokuhlukile. Abanye bangakhubazeka phakathi neminyaka embalwa kanti ezinye zihlala zizinzile amashumi eminyaka.
Izimpawu ezihlobene neCordinal Spord
Ngezimpawu, abantu abahlolwe nge-PPMS bazovame ukubhekana nezinkinga zokuhamba ngenxa ye-atrophy eqhubekayo (ukuchithwa nokuguga) komgogodla. Eyaziwa nangokuthi i-myelopathy eqhubekayo, izimpawu zingase zifake:
- I-gait eqhubekayo ebizwa ngokuthi i-paraparesis ye-spastic, lapho imilenze izoqala ukuqina khona, okwenza ubonakale bunzima obubonakalayo / noma buhle
- Ubuthakathaka noma ukungahambi kahle kolunye uhlangothi lomzimba, okubizwa ngokuthi i-spastic hemiparesis , engathinta imilenze, izingalo, noma izandla
- Yenza ukubekezelelana (ukwehlisa ikhono lokuzivocavoca)
- Ukuhlushwa nokuntuleka komzimba we-muscle ( ataxia )
Uma intambo yomgogodla ithinteka yilesi sifo, ingaphazamisa okungaphezu kokuhamba nje.
Kungabangela ukukhubazeka kwesenzo socansi, isisu nesibilini. Ukukhathala kubuye kuvame nalokhu nakuzo zonke izinhlobo ze-multiple sclerosis.
Izimpawu ezihlobene neBrain
Ngenkathi intambo yomgogodla iyisisusa esiyinhloko sokulimala ku-PPMS, ubuchopho bungabuye buthinteke, ikakhulukazi ingxenye eyaziwa ngokuthi i- cerebellum elawula ukulinganisela nokuhlanganiswa. Eyaziwa ngokuthi i-cerebellar syndrome eqhubekayo (i-PCS), lesi sifo sithinta umuntu ngamunye ku-10 otholakala nge-PPMS futhi angabonakala nge:
- Ukwehluleka kokunyakaza kwesandla esihle ngenxa yokuzamazama okukhulu kwenhloso
- Ukulahlekelwa kwezwi le-muscle (hypotonia)
- Ukulahlekelwa ibhalansi (gait ataxia)
- Ukuhluleka ukuqondisa ukunyakaza (i-dysmetria) lapho umuntu engaphezu kwamanzi noma ukugxila endaweni ehlosiwe yesandla, umlenze, noma isandla
- Ukungakwazi ukwenza ukunyakaza okusheshayo okusheshayo (i- dysdiadochokinesia ) okunjalo ukujibula ku-ampibha
Ukuvuvukala nokuvuthwa kwemvelo kubonakala sengathi yizinqubo eziyinhloko ezisekelwe ku-cerebellar kanye nokubandakanya intambo yomgogodla kwiziguli ze-PPMS.
Izimpawu ezingavamile ze-PPMS
Nakuba kungavamile kakhulu, i-PPMS ingathinta ezinye izingxenye zesimiso sezinzwa ezisemkhatsini ezifana nobuchopho (obuphakathi kobuchopho nomgogodla) kanye ne-cerebrum (umzimba oyinhloko wengqondo).
Izimpawu zibonwa kuphela ngamaphesenti aphakathi kwabantu abane-PPMS kodwa zingabandakanya:
- Izinkinga ngokugwinya ( dysphagia )
- Usizi, ukuhlanza noma isicanucanu
- Ngokushesha, ukunyakaza okungazibandakanyi kwamehlo ( nystagmus )
- Ukukhubazeka kombono noma ukulahlekelwa
- Umsebenzi ongenakwazi ukuqonda , kuhlanganise nokulahlekelwa kwememori, ukucabangela, ukukhuluma kahle, noma ukucabanga okungaphakathi
Izwi elivela
Kuze kube yamuva, bekungekho izidakamizwa ezitholakalayo zokwelapha i-PPMS. Izidakamizwa zendabuko eziguqula izifo, njengeRebif neCopaxone, zisebenza kakhulu ngokunciphisa ukuvuvukala okuhambisana ne-RRMS, kodwa ziye zafakaza ukuthi aziphumelelanga ekuphatheni uhlobo lokuguqulwa kwesisindo okubonwe ku-PPMS.
Ngenhlanhla, izinto zishintshile. Manje sinezidakamizwa ezaziwa ngokuthi i- Ocrevus (ocrelizumab) ekwazi ukuphatha i-PPMS kanye nokuvuselela amafomu wesifo. Kuvunyelwe yi-US Food and Drug Administration (FDA) ngo-Mashi 2017, i-Ocrevus ibhekwa njengenguquko enkulu yemidlalo futhi cishe izothuthukisa izimpilo zalabo abaphila nale ndlela engavamile ye-multiple sclerosis.
> Imithombo
> Ohrbach, R .; I-Zhao, A .; Wang, Y. et al. "Ukuqhathaniswa kweMisebenzi yezifo ku-SPMS naku-PPMS ku-Context of Multicenter Clinical Trials." PLoS One 2012; DOI 10.1371 / journal.pone.0045409.
> Ukuphathwa Kwezokudla Nezidakamizwa zase-US. "I-Ocrevus (ocrelizumab) Injecting." I-Silver Spring, e-Maryland; Mashi 28, 2017.