Uma amazinga akho e-triglyceride ephakanyisiwe, ukuhlinzeka ngempilo yakho kunganquma ukuzama nokunciphisa amazinga akho ngokushintsha indlela yakho yokuphila. Lokhu kufaka ukwenza ukudla kwakho kube nokuphilile, ukulahlekelwa isisindo, noma ukubhekana nezimo zezokwelashwa - njengesifo sikashukela esingalawulwayo - okungabangela amazinga akho e-triglyceride ukuba aphakeme kakhulu. Uma lezi zinguquko zingasebenzi - noma uma i-triglycerides yakho iphakanyisiwe kakhulu - umhlinzeki wakho wezempilo uyokwazi ukunquma imithi.
Yilapho imithi efana ne-Vascepa ingahle ibekiwe kuwe.
I-Vascepa (i-ethyl e-icosapent) ifomu eliguquguqukayo le-omega-3 fatty acid, eicosapentaenoic acid (EPA), futhi ithathwa ngabantu abaye bahlolelwa ukuthi bane- hypertriglyceridemia enamandla, equkethe amazinga e- triglyceride amakhulu kunani noma afana ne-500 mg / dL . Uma ngabe umisiwe lo muthi okufanele uwuthathe, kufanele futhi ulandele ukudla ukuze unciphise amazinga akho e-triglyceride. I-Vascepa yavunyelwa ukusetshenziswa e-United States yi-Food and Drug Administration (FDA) ngoJulayi 2012.
Kukhona izifundo ezimbalwa eziye zahlola ukuphepha nokusebenza kweVascepa ekunciphiseni i-triglycerides. Ucwaningo olubalulekile, isilingo se-MARINE, siqhathanisa ikhono lokunciphisa i-Vascepa endaweni ye-placebo kubantu abanamazinga we-triglyceride phakathi kuka-500 no-2000 mg / dL esikhathini seviki eziyi-12. Uma kuqhathaniswa ne-placebo, amazinga e-triglyceride anciphisa cishe ama-33% kulabo abathatha amagremu amane e-Vascepa nsuku zonke.
Ukwengeza, i- VLDL yanciphisa ngo-28.6%. I-LDL ne- HDL yanciphisa kancane, kepha lokhu ukunciphisa kwakungabonakali kakhulu. Akukho ukungafani okuphawulekayo kwezibonakaliso ezibalulekile, amazinga kashukela egazi, kanye nama-enzyme e-isibindi abonakala kubantu abathatha i-Vascepa uma kuqhathaniswa nalabo abathwala indawo.
I-Vascepa isebenza kanjani?
I-Vascepa isebenza ngokunciphisa inani le-triglyceride elenziwe esibindi.
Ukwengeza, i-Vascepa ikwandisa ukususwa kwe-triglycerides kusuka ku-VLDL izinhlayiya ezijikelezayo egazini lakho. Indlela eqondile eyenziwa ngayo nguVascepa lokhu, nakuba kuye kwaba nezinqubo eziningana ezihlongozwayo.
Kufanele Usithathe Kanjani Le Mithi?
Kumele uthathe i-Vascepa njengoba kunqunywe umhlinzeki wakho wezempilo. Isilinganiso esivamile sikaVascepa siqukethe ukuthatha ama-capsules amabili kabili ngosuku (inani elingama 4 amagremu). Ama-capsules kufanele athathwe ngokudla futhi akufanele achotshozwe, ahlaziwe noma aqedwe ngesigamu. Kufanele futhi ulandele indlela yokuphila enempilo - njengokuthola ukuzivocavoca okulinganiselayo nokulandela ukudla okunempilo - ngaphambi nangesikhathi uthatha i-Vascepa.
Yiziphi Imiphumela Ezingadingeki Ngilindele Ngesikhathi Ngithatha I-Vascepa?
Ezicwaningweni, imiphumela emibi kakhulu ebikwa yi-diarrhea kanye ne-nausea, nakuba abantu abaningi bethatha i-placebo nabo bahlangabezana nalezi zemihelo. Ungase ubuzwe ubuhlungu obufanayo kanye nomphimbo, ngoba lemiphumela emibi nayo ibonakala kubantu abathatha i-Vascepa.
Kumele uvumele umhlinzeki wakho wezempilo ukuthi aziphi izinhlobo zemiphumela emibi lapho uthola i-Vascepa - ikakhulukazi uma ehlupha noma ephazamisa imisebenzi yakho yansuku zonke.
Ubani Ongayithathi Le Mithi?
Akufanele uthathe i-Vascepa uma uke wabhekana nesifo esibi kakhulu ku-Vascepa noma noma yiziphi izithako zayo.
Ngenxa yokuthi i-EPA eguquliwe itholakala kumafutha avela ezinhlanzi, i-Vascepa kufanele isetshenziswe ngokucophelela uma unomdlavuza wokudoba noma i-shellfish. I-Vascepa ayingafundiwe kubantu abanenhlanzi noma i-shellfish yokungezwani komzimba.
I-Vascepa nayo ayizange ifunde kabanzi kubantu abanezinso zezinso noma zesibindi. Uma unesibindi noma isifo senhliziyo noma ukukhubazeka, kufanele uvumele umhlinzeki wakho wezempilo ukuthi azi. Uzonquma ukuthi uVascepa noma u-Vascepa uyakufanele yini futhi aqapha isimo sakho ngenkathi ususelwa emithini.
Lo mkhiqizo nawo awusandulwanga ngabesifazane abakhulelwe noma abancelisayo.
Ngakho-ke, i-Vascepa kufanele ithathwe kuphela uma idingeka ngokucacile.
Ingabe Le Mithi izosebenzisana Nezinye Izidakamizwa Engizithathayo?
Akukho kubonakala sengathi kukhona ukuxhumana okuningi phakathi kweVascepa neminye imithi. Nakuba uVascepa engabonakali ehlangene nemithi ye-anticoagulant noma ukuba nomthelela omkhulu ekuphumeni kwegazi, ezinye izifundo zibonise ukuthi ukuphakama okukhulu kwamafutha e-omega-3 ama-acids kunganciphisa ikhono legazi lakho ukuvala. Ngakho-ke, uma uthatha noma yiluphi uhlobo lwemithi echaphazela ikhono lakho legazi lokugqoka, umhlinzeki wakho wezempilo uyohlola isimo sakho se-anticoagulation ngezikhathi ezithile. Kumele futhi uvumele umhlinzeki wakho wezempilo ukuba azi ukuthi uthatha noma yimiphi iminye imithi, izithako ze-herbal, noma imikhiqizo engaphezu kwe-counter ngaphambi kokuqala i-Vascepa.
Ngaphansi
Ucwaningo luye lwabonisa ukuthi i-Vascepa inganciphisa amazinga e-triglyceride kubantu abaye bathola ukuthi banamazinga aphakeme kakhulu e-triglyceride engaphezu kuka-500 mg / dL. Ngaphandle kokuthatha i-Vascepa, ezinye izici ezingakhuphula amazinga e-triglyceride - njengokudla, umsebenzi womzimba, ezinye izidakamizwa, noma izifo ezithile, ezifana ne-hypothyroidism noma isifo sikashukela - kufanele futhi zibhekiswe. Amazinga we-triglyceride aphakanyisiwe akhonjisiwe ekuholeni ekuthuthukiseni isifo senhliziyo kanye nokuvuvukala okukhulu kwamaphancasi, noma i-pancreatitis. I-Vascepa ayizange isetshenziswe ekuvimbeleni isifo senhliziyo nesiguli noma isikhathi eside, nakuba kubonakala sengathi isifundo siyaqhubeka sihlola ikhono leVascepa lokuvimbela umcimbi wokuqala wezinhliziyo kubantu abane-triglycerides ephakeme kakhulu.
Imithombo:
> Ballantyne CM, Bays HE, Kastelein JJ et al. Ukusebenza nokuphepha kwe-eicosapentaenoic acid ethyl ester (AMR101) ukwelashwa kweziguli eziphathwe izimo ezinezintambo eziphakeme eziqhubekayo (kusukela ocwaningweni lwe-ANCHOR). Am J Cardiol 2012; 110: 982-992.
Ama-HE, i-Braeckman RA, i-Ballantyne CM, et al. I-icosapent ethyl, i-EPA e-omega-3 fatty acid ehlanzekile e-EPA: imiphumela ye-lipoprotein i-particle concentration kanye nobukhulu ezigulini ezinezinga eliphezulu kakhulu le-triglyceride (isifundo se-MARINE). J Clinic Lipidol 2012; 6: 565-572.
I-Nelson SD, i-Munger MA. I-ethyl ye-icosapent yokwelashwa kwamazinga aphezulu e-triglyceride. U-Ann wezimpahla zomzimba 2013; 27: 1517-1523.
> Vascepa® (icosapent ethyl) Iphakheji Faka. Amarin Pharmaceuticals. Juni 2015.