Ukuthi ukudla okunomsoco ku-berberine kunika kanjani ithemba kubesifazane abahlukunyezwa yi-PCOS.
I-Berberine iyisekele lasendulo elase lisetshenziswa eChina iminyaka eyizinkulungwane njengendlela yokwelapha isifo sikashukela, isifo sohudo, nokungabi namuntu. Manje ucwaningo luqala ukuphenya ukusetshenziswa kwalo kwabesifazane abane-polycystic ovary syndrome ( PCOS ) kuze kube manje, imiphumela iyakhuthaza kakhulu.
Kuyini i-Berberine?
I-Berberine i-alkaloid ekhishwa ngamagatsha aseShayina njenge-hydrastis cacadensis (igolideenseal), i-berberis aquifolium (i-oregon yamagilebhisi), i-berberis vulgaris (i-barberry), i-berberis aristata (i-turmeric), ne-coptidis rhizome (i-huanglian).
Kungathathwa njenge-capsule noma ifomu eliketshezi.
Ukuthatha i-berberine kuye kwaboniswa ukusiza ngokuthuthukisa izimo eziningi zezinhlobo eziningi, ngezinzuzo ezinjengalezi:
- Ithuthukisa ukuphikiswa kwe-insulin
- I-downtosterone ephansi
- Kunciphisa induna
- Ihlisa izinga lama-cholesterol
- Kuthuthukisa isifo sesibindi esingenalo utshwala
- Ithuthukisa ukukhulelwa nokuzala
- Inikeza ukusekelwa kwe-Immune
- Inikeza izinzuzo zokulwa nama-microbial
- Ihlisa izinga lokucindezela kwegazi
- I-AIDS ekulahlekeni kwesisindo nokulahlekelwa komzimba
- Ukwelashwa okulwa nomdlavuza
I-Berberine ne-PCOS
I-Berberine ingahlinzeka izinzuzo eziningi kubesifazane abane-PCOS kuhlanganise nokuthuthukisa ukuzala, ukusiza ukulahlekelwa isisindo, nokunciphisa ingozi yokunciphisa umzimba okuhambisana ne-syndrome efana ne-type 2 yesifo sikashukela, i-cholesterol ephezulu nesifo sesibindi esinamafutha.
I-Potent Sensitizer Enamandla
Mhlawumbe indima enkulu ye-berberine ingumsizi omkhulu we-insulin. Abesifazane abane-PCOS baye baboniswa ukuthi banezinga eliphezulu le-insulin uma kuqhathaniswa nabesifazane besisindo esifanayo ngaphandle kwesimo.
I-Metformin iyi-insulin-evuselela imithi evame ukubekwa kwabesifazane abane-PCOS ukusiza ukuphatha amazinga e-insulini nama-glucose. Kodwa-ke, abesifazane abaningi abane-PCOS bahlangabezana nemiphumela emibi yezinyo zomzimba ze-metformin efana nesifo sohudo, isicanuca, nesisu esiswini. Ukusetshenziswa kwe-metformin yesikhathi eside kuye kwaboniswa ukuthi kuthinte ukungena kwe- vitamin B12 .
I-Berberine iye yaboniswa ukuthi ithuthukise ukuphikiswa kwe-insulin ngendlela efanayo kuya kwe-metformin. I-Berberine ithuthukisa ukudluliswa kwesignali ye-insulin ngokukhuthaza ukudla kwe-glucose nge-activation ye-AMP-activated protein kinase.
Izinzuzo zeBelberine ziye zafaniswa ne-metformin kubesifazane abane-PCOS. Esifundweni esashicilelwe kuyi- European Journal of Endocrinology , u-Wei kanye nozakwethu bakhetha ngezikhathi ezithile abesifazane abangu-89 nge-PCOS ukuthola i-berberine (500 mg, kathathu ngosuku), metformin (500 mg, izikhathi ezintathu ngosuku), noma indawo ye-placebo ye-3 izinyanga.
Bonke abesifazane bafundiswa umsoco wokunciphisa ukudla ukuze banciphise ukudla kwabo ama-carbohydrate namafutha. Uhla lwekhalori aluzange lunikezwe. Abesifazane babuye bafundiswe ukuba basebenzise imizuzu engu-30 ngosuku ngalunye ngokuzivocavoca okukhulu.
Ngemuva kwezinyanga ezintathu zokwelashwa, abesifazane abano-PCOS abathatha i-berberine babona ukunciphisa okukhulu ekulahlekeni komzimba kunemetformin noma i-placebo. I-Berberine yanciphisa amazinga e-insulin nama-glucose afana ne-metformin.
Abesifazane abane-PCOS abathatha i-berberine babona ukunciphisa okukhulu kwe- cholesterol , i-LDL (amazinga ama-cholesterol amabi), kanye ne-triglycerides kanye nokuthuthukiswa okukhulu kwe-HDL (amazinga ama-cholesterol amahle), ngaphezu kokuthatha i-metformin noma i-placebo.
Ngaphezu kwalokho, ukuthatha amazinga e-testosterone esiphezulu ama-berberine afana ne-metformin.
Ukuthuthukisa Ukuzala
Ngesikhathi i-berberine ibonisa izinzuzo ekuthuthukiseni izinkinga ze-PCOS, kungase kuthuthukise nokuzala . Esifundweni somshayeli, abesifazane abangu-98 abavuvukala abane-PCOS banikezwa i-berberine. Ukuvuthwa kwamanzi kuthuthukiswe ngamaphesenti angu-25 emva kwezinyanga ezingu-4 ukuthatha i-berberine.
Ucwaningo olwanyatheliswa ku- Clinical Endocrinology lubonise ukuthi abesifazane abane-PCOS abakhethwe ngezikhathi ezithile ukuthatha i-berberine, babe nezinga eliphezulu lokukhulelwa kune-metformin noma i-placebo kanye nemiphumela emibi kakhulu uma kuthathwa amasonto angu-12 ngaphambi kokuphathwa kwe-IVF.
Ukusiza Nge-Los Weight Loss
Cishe noma yikuphi abesifazane abano-PCOS abangakutshela ukuthi ukulahlekelwa isisindo kunzima kulabo abanesimo. Futhi ukulahlekelwa isisindo kunzima ngezizathu eziningi kubandakanya ukwanda kwe-insulin ukumelana, izifiso eziqinile ze-carbohydrate, kanye nomthetho wokungadli ukudla okunomsoco.
I-Berberine inganikeza ithemba kubantu besifazane abane-PCOS abahlukumezayo ngesisindo sabo. I-Berberine iye yaboniswa ukunciphisa ukufihla kwesifiso esithinta i-hormone leptin . I-Berberine nayo ibonise ukuthi iphumelela ekusizeni isisindo nokulahlekelwa komzimba ngokuvimbela i-enzyme lipoprotein lipase, eyabangela ukugcina amafutha. Imiphumela ephawulekayo yokuthatha i-berberine ezikoleni eziningi isisindo sokulahlekelwa isisindo, ikakhulukazi phakathi kwesigaba somzimba, kanye namazinga aphansi we-body mass index (BMI).
Ukunciphisa Ubuthi Bamafutha
Abesifazane abane-PCOS basengozini enkulu yokuba ne-fatty fover disease ngenxa yobuhlobo namazinga aphezulu e-insulin. I-Berberine iboniswe ukuthi iyindlela ephumelelayo yokunciphisa isibindi samafutha. Ukubuyekezwa kwezilingo eziyisithupha zokulawulwa kwezilawuli ezibandakanya abantu abangu-500, bathola ukuthi i-berberine yanciphisa kakhulu isibindi esinamafutha kulabo abanezifo ezingenaso utshwala (NAFLD). I-Berberine yanciphisa ama-enzyme e-TG nesibindi sokusebenza, futhi kusetshenziselwa ukusebenza kwesibindi jikelele. Kutholakale ukuthi i-berberine ithuthukisa i-NAFLD ngokuvimbela amafutha e-isibindi awakhulisa futhi akhuthaze uketshezi lwe-fatty acid ku-muscle we-squelette.
Okufanele Ukwazi Ngokuthatha I-Berberine
Ngokuvamile, i-berberine ibekezelelwe kahle kodwa ngezinye izikhathi ingabangela imiphumela emibi emathunjini kubandakanya ukucwenga nokuqothulwa, ikakhulu uma isetshenziselwa ukulinganisa okuphezulu.
Umthamo wokwelapha we-berberine ukuthuthukisa i-insulin nezinye izinzuzo zezempilo eziqinisekisiwe ngu-500 mg, izikhathi ezintathu ngosuku (okufana neyomthamo we-metformin). Ukuze ugweme ukuguqulwa kwe-GI, kungase kube ngcono ukunciphisa kancane ku-1,500 mg nsuku zonke ngokuthatha ama-500 mg ngesonto lokuqala, ungeze elinye i-500 mg ngesonto lesibili, uze ufinyelele ku-1,500mg ngesonto lesithathu.
I-Berberine ayihloselwe ukusetshenziswa kwesikhathi eside. Ayikho idatha etholakalayo mayelana nokuphepha kwe-Berberine phakathi kwabesifazane abasebasha noma ekukhulelweni kokuqala. I-Berberine ayikhuthazwa ngesikhathi sokukhulelwa noma i-lactation.
I-Berberine ingase ishintshe ukuvinjelwa kwesibindi kwemithi ethile. Ukucwayiswa Kunconywa uma uthatha iminye imithi enqunyiwe njengama- antidepressants , ama-MAO okuvimbela, abagcini begazi kanye ne-beta-blockers. Ukuqapha okuqhubekayo kokuhlolwa kokusebenza kwesibindi kunconywa kulabo abathatha i-berberine. Njengoba i-berberine i-insulin-sensitizer, ingabangela ushukela ophansi wegazi, ikakhulu uma ihlanganiswa neminye imithi yokunciphisa i-insulin efana ne-metformin noma izithako ezifana ne- inositol noma i- n-acetylcysteine. Xhumana nodokotela wakho ngaphambi kokuthatha i-berberine.
> Imithombo:
> Y, Sun Z, Zhang Y, Liu B, Guan Y, Lu M. Ukusetshenziswa kwe-berberine kwabesifazane abane-polycystic ovary syndrome ephathwa ngemithi ye-IVF. I-Clin Endocrinol (i-Oxf). 2014 Mar; 80 (3): 425-31.
> Chang X et al. Ukuprofetha kwe-Lipid yemiphumela yokwelapha ye-berberine ezigulini ezinezifo ezingenagciwane ezinobuthi. 2016 Sep 15; 14: 266.
> Lin L et al. Isifundo se-Single Arm Pilot Study of Effects of Berberine on Pattern Patterns, Izinga lokuvota, Amaphrofayli amaHormonal kanye namaMetabolic ku-Women's Epidemic Chinese Women's Polycystic Ovary Syndrome. PLoS One. 2015; 10 (12): e0144072.
> Wei W, et al. Ucwaningo olusemtholampilo ngomphumela wesikhathi esifushane waseBerberine uma kuqhathaniswa ne-metformin ngezici zokuqubuzana zabesifazane abane-polycystic ovary syndrome. I-Eur J Endocrinol. 2012 Jan; 166 (1): 99-105.
> Yang J et al. I-Berberine ithuthukisa ukuzwela kwe-insulini ngokuvimbela isitolo se-fat nokulungisa iphrofayela ye-adipokines kuma-preadipocyte wabantu neziguli ze-metabolic syndrome. I-Evid Based Based Complement Alternat Med. 2012: 363845.