Izithako ezintathu ezingasiza ukubuyisela ukusebenza komakhalekhukhwini
Nakuba izifo zokwelapha eziningi ze-multiple sclerosis (MS) zigxila ekunciphiseni ukuvuvukala ebuchosheni nasemgqeni womgogodla, abacwaningi manje baphenya ngemithi yokwelashwa engasiza ukulungisa into eyona eyonakalisiwe futhi ibhujiswe ku-MS-i-myelin sheath.
Ngokubuyisela umgogodla we-myelin , kunethemba lokuba umsebenzi wezinzwa zegazi ungabuyiselwa.
Okumangalisa nakakhulu ukuthi lezi zindlela zokwelapha ezivuselela izifo zitholakala ezitolo zokudla noma endaweni ekhemisi. Izintathu kulezi zithako zokudla zihlanganisa:
- I-Biotin
- I-Vitamin D
- Omega-3 fatty acids
Lokho kusho ukuthi kubalulekile ukuqonda ukuthi ukuhlolwa kwalezi zithako kanye nendima yabo e-MS kusekuseni kakhulu futhi kwenziwa ngokungabaza.
Ngaphezu kwalokho, ngenkathi izithako zingase zibe ukufakazela okunengqondo (hhayi okunye esikhundleni) kumathambo akho okwamanje we-MS, kubalulekile ukuthatha kuphela ngaphansi kokuqondiswa kukadokotela wakho.
Ukuqapha ukusetshenziselwa ukwesekwa kubalulekile ngezizathu eziningi, kufaka phakathi ikhono lobuhlungu noma ukuthi ezinye izithako, njenge-omega-3 fatty acids, zingathinta ukusebenza kwezidakamizwa ze-MS noma ezinye izidakamizwa ozithathayo.
I-Biotin e-Myelin Ukulungisa ku-MS
I-Biotin iyinvithamini ehilelekile kokubili amandla kagesi nokudala ama-acids amafutha emzimbeni.
Itholakala ekufakeni izithako zokudla izinwele, isikhumba, ukukhula kwe-nail, kanye nama-multivitamini kanye namavithamini okubeletha.
Njengoba i-myelin sheath isembozo esinamafutha, abacwaningi bacabanga ukuthi ngokunikeza abantu amazinga aphezulu we-biotin (njengama-300mg ngosuku), kungenzeka ukuthi i-myelin sheath ingabuyiselwa.
Ngaphezu kokubuyisela i-myelin (i-fat cover), abanye ososayensi bakholelwa ukuthi i-biotin inganciphisa ukuwohloka kwama-axon ngokuthuthukisa ukukhiqizwa kwamandla.
Ukuwohloka kwe-axon kwenzeka ikakhulukazi ezinhlobonhlobo ze-MS futhi kubhekisela ekulahlekelweni kwezintambo zezinzwa futhi ekugcineni kufinyeleleke kwesisindo selifele.
Isithombe esikhulu lapha ukuthi ochwepheshe bacabanga ukuthi i-biotin ingasebenzisa umphumela wayo wokwelashwa ngezindlela ezimbili-ibhonasi kabili. Kuze kube manje, ubufakazi besayense obusekela indima ye-biotin ekwelapheni i-MS bukhulu futhi bungaqondile.
Ake sibheke ngokucophelela izifundo ezimbalwa ezibonisa le miphumela ehlanganisiwe.
Izindwangu Kuze ku-Biotin
Esifundweni esincane ku- Multiple Sclerosis kanye Nezifo Ezihlobene Nalokho, abantu abangu-23 abane-MS eyinhloko noma eyesibili eyathuthuka banikezwa amazinga aphezulu we-biotin, futhi ukuthuthukiswa kwabonakala ezinhlobonhlobo ezihlukahlukene, ikakhulukazi izinyathelo zombono, izinkinga zomgogodla kanye nokukhathala.
Imiphumela Ehlanganisiwe ye-Biotin
Ucwaningo olwengeziwe ku- Multiple Sclerosis lwembula ukuthi i-high-dose biotin yenza ngcono ukukhubazeka okuhlobene ne-MS kumaphesenti angaba ngu-12 abahlanganyeli abane-MS. Noma kunjalo, iqiniso lokuthi amaphesenti angu-12 kuphela abonisa ukuthuthukiswa kubonisa ukuthi kungenzeka ukuthi i-subset kuphela yabantu abane-MS bangazuza ngokuthatha i-biotin.
Ngaphezu kwalokho, kuyadabukisa ukuthi abaphenyi kulolu cwaningo baqaphele ukuthi labo abathatha i-biotin babenezinyathelo ezintsha noma ezikhulisa ubuchopho ezinganeni zabo ze-MRIs uma kuqhathaniswa nalabo abaseqembu le-placebo.
Abaphenyi babuza ukuthi ngabe i-biotin yayishukumisa impendulo yokuvuvukala (lokhu bekungeke kube kuhle).
Izindwangu ZaseBiotin
Ucwaningo lwesithathu lubangela ukukhathazeka okwengeziwe nge-biotin. Kulesi sifundo, kwakungekho ukuthuthuka kokukhubazeka okuhlobene ne-MS kubantu abane-MS abaqhubekayo. Eqinisweni, cishe ingxenye eyodwa kwezintathu kwabahlanganyeli bebhekene nesifo esibucayi, ikakhulukazi ngokubuthakathaka obuningi bomlenze, ibhalansi embi nakakhulu.
Yiqiniso, ukuwohloka kwesifo sabo kungahambisani ne-biotin futhi ngenxa yokuqhubeka kwemvelo kwe-MS. Kodwa-ke, abaphenyi besifundo babecabanga ukuthi i-biotin ephezulu kakhulu inokwenza okuthile.
Mhlawumbe, i-biotin yashintsha isidingo somzimba sokungabi namandla ekuvimbeleni ubuchopho nentambo yomgogodla, okwenza isimiso somzimba sokuzivikela siphumelele.
Indima ye-Vitamin D ku-Myelin Repair
I-Vitamin D itholakala ekufakeni izithako, kanye nokudla okufana ne-salmon, i-cod ye-over, i-tuna ekheniwe, izikhupha ze-egg, nama-egg enamaqanda, ubisi, nejusi le-orange.
Ngokusekelwe ezifundweni eziningi, siyazi ukuthi ukungabi naso kwe-vitamin D kwandisa ithuba lomuntu lokuthuthukisa i-MS . Kodwa-ke, uma umuntu esenayo i-MS, akucaci kahle ukuthi noma i-vitamin D ingathinta kanjani umsebenzi wabo wesifo (njengokuthi ukutholakala kwe-vitamin D kungakwandisa amathuba omuntu wokuba ne-MS ephindaphinda).
Ngenkathi ucwaningo oluthile lwe-vitamin D luye lwagxila kakhulu ekutheni lubangele kanjani noma luthonya i-MS, isifundo sokuvula amehlo ku -Journal of Cell Biology sikhanyisa inxenye yesithathu ye vitamin D ku-MS-ukuthi i-vitamin D ingabandakanyeka ekubuyiselweni kwami kwe-myelin.
Lolu cwaningo luthole ukuthi amaphayinti amavithamini D receptor aneprotheni okuthiwa i-retinoid X receptor-gamma (RXR gamma receptor), okuyinto iphrotheni ehilelekile ekulawuleni ukuvuthwa kwamaseli akhiqiza i-myelin (ebizwa nge-oligodendrocyte).
Abaphenyi bathola ukuthi uma bangezela ama-vitamin D ebuchosheni amakhemikhali ahlanganisa i-RXR gamma receptor, inani lama-oligodendrocytes eliveza i-myelin protein eyisisekelo (ingxenye enkulu yamaprotheni engxenyeni ye-myelin) yanda ngamaphesenti angu-80.
Ngamanye amazwi, i-vitamin D yavuselela ukubuyiselwa kwe-myelin-is amazing feat. Yiqiniso, lokhu kuyisifundo esisodwa, futhi ezinye izifundo eziningi kudingeka zenziwe ukuze kucaciswe lokhu okutholayo. Konke, nokho, lolu cwaningo lubonisa iqhaza elikhulu le- vitamin D elidlala kwimpilo yakho ye-MS.
Indima yama-Omega-3 Acat Acids ku-Myelin Repair
I-omega-3 fatty acids itholakala kumafutha "amahle" abizwa ngamafutha e-polyunsaturated. Lawa mafutha amahle akhona ekudleni okufana nalokhu:
- Izinhlanzi ezinamafutha (isibonelo, i-saumon, i-mackerel, i-herring, ne-sardine)
- Imbewu ye-Chia
- Ama-flaxseeds
- AmaSoybe
- Ama-Walnuts
- Amafutha e-canola
Izithako zamafutha ezinhlanzi ziqukethe i-omega-3 fatty acids.
Ubufakazi besayensi obusekela ukudla ukudla okucebile omega-3 fatty acids ekuphatheni i-MS kuxubekile. Ngamanye amazwi, kukhona idatha elinganiselwe ebonisa ukuthi inciphisa i-MS iphinda ibuyele noma iphuze ukuqhubekela phambili kokukhubazeka okuhlobene ne-MS.
Lokho kusho, kuyathakazelisa ukuphawula ukuthi izifundo zamuva zezilwane ziye zembula ukuthi ama-omega-3 fatty acids angase akhuthaze ukuvuselelwa. Kodwa-ke, (futhi yilapho kukhona ukudideka okukhona khona), uma ama-omega-3 fatty acids asiza ukubuyisela i-myelin, khona-ke ukuthuthukiswa kokukhubazeka ezikoleni zangaphambili zeziguli ezine-MS kufanele kubonwe. Lokhu ukungavumelani kuye kwashiya abacwaningi bashaya amakhanda abo.
Konke, kungenzeka ukuthi indima yokusetshenziswa kwe-omega-3 ku-MS iyinkimbinkimbi, futhi inzuzo yayo ingatholakala kwezinye izici ezihlobene. Mhlawumbe, ukuthola i-omega-3 ngokwemvelo ngokuphambene nokungezezela kuthinta imiphumela, noma mhlawumbe, abanye abantu abatholi i-omega-3 kanye nabanye.
Ngaphezu kwalokho, i-omega-3 fatty acids ingadilizwa zibe izingxenye ezimbili, i-eicosapentaenoic acid (EPA) ne-docosahexaenoic acid (i-DHA). Kungenzeka ukuthi isilinganiso sokuthi lezi zingxenye zidliwe zingathinta kanjani imiphumela yocwaningo.
Okubalulekile ukuthi uphenyo oluningi luzodingeka lwenziwe ukuvula izinzuzo zangempela (uma kunjalo) zama-fatty acids ama-omega-3 ekuphatheni i-MS. Lokhu kuyiqiniso ngokukhethekile kubantu abane-MS eqhubekayo, njengoba izifundo kuze kube manje ziye zagxila kubantu abane-MS yokubuyisela kabusha.
Izwi elivela
Kuyaphawuleka ukucabanga ukuthi singene kangakanani ekuqondeni kangcono nokuphatha i-MS. Ngokuphenya ngezinqubo zokwelapha ezithinta i-MS kusuka ekugcineni kokubili (ukuvimbela umonakalo we-myelin bese ubuyisela i-myelin eye yayisilimale kakade), kukhona ithemba langempela lokuphela kwalesi sifo.
Uma une-MS (noma othandekayo wenza), hlala uphephile empilweni yakho yansuku zonke-hlala usesikhathini kulwazi lwe-MS, qhubeka nemithi yakho ye-MS, finyelele kwabanye ukusekela, futhi okubaluleke kakhulu ukujabulela izikhathi eziyigugu zokuphila.
> Imithombo:
> Birnbaum G, Stulc J. High umthamo biotin njengoba ukwelashwa for okuqhubekayo multiple sclerosis. I-Mult Scler Relat Disord . 2017 Nov; 18: 141-43.
> de la Fuente AG et al. Ukwamukelwa kwe-heterodimer ye-receptor-retinoid X yokulawula i-oligodendrocyte progenitor cell cell differentiation. J Cell Biol. 2015 Dec 7; 211 (5): 975-85.
> Sedel F et al. Isilinganiso esiphakeme se-biotin ekuqhumeni okuqhubekayo okuqhubekayo kwe-sclerosis: isifundo somqhubi. I-Mult Scler Relat Disord . 2015 uMar; 4 (2): 159-69.
> Torkildsen O et al. Ukwelapha ama-ω-3 e-fatty acid ku-multiple sclerosis (i-OFAMS Study): isilingo esilawulwa ngokungahleliwe, esiphezulu, esiphambene naso. Arch Neurol . 2012 Aug; 69 (8): 1044-51.
> Tourbah A et al. MD1003 (i-high-dose biotin) ekwelapheni ukuqhuma okuqhubekayo okuqhubekayo: Ucwaningo olulawulwa ngokungahleliwe, oluphindwe kabili, oluyimpumputhe. I-Mult Scler. 2016 Nov; 22 (13): 1719-31.