Ukuhlanganiswa Kwama-bacterial of the Lungs With Cystic Fibrosis
Kungenzeka ukuthi uke wezwa ngokukhishwa kwamagciwane uma uhlala ne-cystic fibrosis. Kusho ukuthini lokhu?
Kuyini ukuKoloni?
I-Colonization ivela lapho ama-microorganisms ahlala khona noma emzimbeni ongasondeli kodwa angahlaseli izicubu noma abangela umonakalo. Ukwakhiwa koloni kubhekisela ekubeni khona kwezincane ezincane ezingabangela ukutheleleka, kepha hhayi ekuthelelekeni ngokwayo.
Ukuba nalezi zinambuzane ezikhona, nokho, kwandisa ingozi yokutheleleka uma indawo efanelekile yokutheleleka kwenzeka.
Ukubaluleka kobuKoloni ku-Cystic Fibrosis
Abantu abane- cystic fibrosis (CF) bavame ukukhonjiswa ngamabhaktheriya, ikakhulukazi emasikini nasezindiza. Uma izilwane ziqala ukuhlasela izicubu futhi zidale umonakalo noma zenze umuntu agula, ukoloni luba yisifo.
Izinguquko Zemizila Yokuphefumula Kwabantu Abano-Cystic Fibrosis
Kubantu abanesifo se-cystic fibrosis, ukucindezeleka ngokweqile kwe-mucus nokutheleleka okungapheli kwamagciwane kubangela uhlobo olukhethekile lwe-chronic obstructive pulmonary disease. Abantu abane-cystic fibrosis ekugcineni bahlakulela i- bronchiectasis lapho i-airways ikhubazekile kakhulu futhi ibonakala khona.
I-Bronchiectasis yisimo lapho amabhononi nama- bronchioles (amagatsha amancane e-airways) eqina, avuliwe futhi anesifo. I-Mucus iqoqa kulezi zimoya ezinwetshiwe ezithinta ukutheleleka.
Ukutheleleka okuholela ekutheni kube nokuqina okukhulu, ukukhulisa nokukhwabanisa kwezindiza eziphindaphinda umjikelezo ononya.
Ngaphandle kwe-bronchi ne-bronchioles i- alveoli , ama-sac amancane emoyeni lapho kwenzeka khona ukushintshaniswa kwe-oxygen ne-carbon dioxide. Lapho ama-bronchioles eholela kulezi zindlela ezincane kakhulu zokuhamba emoyeni zilahlekelwa ukuhluma kwazo (kusukela ekukhunjweni nasebunqeni) futhi ziboshwe nge-mucus, i-oksijini ehanjiswe emaphashini ayikwazi ukuthola i-alveoli ukuze lokhu kuhanjiswa kwegesi kwenzeke.
Kungani Imifula Ephakathi Kwabantu abane-Cystic Fibrosis Iveza I-Mucus Eyengeziwe?
Akucaci ukuthi ngabe abantu abane-cystic fibrosis ekuqaleni bakhiqiza i-mucus e-viscid ngokweqile noma benza kanjalo ngenxa ye-colonization yamagciwane. Kodwa-ke, ukuhlolwa kwamapayipi ezinganeni ezisanda kuzalwa ne-cystic fibrosis ezingakaze zihlanganiswe ngamabhaktheriya kubonisa ukukhiqizwa okwedlulele kwe-mucus. Lokhu kutholakala kusikisela ukuthi i-mucus ibeka abantu abanesifo se-cystic fibrosis ekoloni nge-bacteria.
Yiziphi izinhlobo zamaBhaktheriya ezihlanganisa imibuthano yabantu abaneCystic Fibrosis?
Izinhlobo eziningi zamabhaktheriya aerobic (amabhaktheriya akhula phambi kwe-oksijeni), amabhaktheriya anaerobic (amabhaktheriya akhule ngaphandle kwe-oksijeni) kanye nezifo ezifuywayo ezibonakalayo ezinjengefungus zihlanganisa amaphaphu abantu abane-cystic fibrosis. Amagciwane amabizo asetshenziselwa ukuchaza amancane ezincane ezingabangela ukutheleleka kubantu abaphilile kodwa angabangela ukutheleleka uma "ithuba" livela, njengokuthi isifo se-lung lungatholakala.
Nazi ezinye izinto ezihlanganisa amaphaphu abantu abane-cystic fibrosis:
- Pseudomonas aeruginosa
- I-Staphylococcus aureus (kufaka phakathi i- MRSA )
- Escherichia coli
- I-Haemophilus influenzae
- Klebsiella
- I-Prevotella
- Propionibacterium
- Veillonella
- I-Aspergillus (funda mayelana ne-bronchopulmonary aspergillosis kubantu abane-cystic fibrosis)
Uhlobo Oluthile Oluvamile Lwezifo Eziphilayo Ezihlanganisa I-Airways Kwabantu Nge-CF
Kulezi zilwane ezingenhla, ukoloni kanye nePseudomonas ngokuvamile kubangelwa futhi cishe amaphesenti angama-80 abantu abadala abane-cystic fibrosis bahlanganiswa nalolu hlobo lwamagciwane.
Ama-Multidrug-Resistant Organisms ne-Cystic Fibrosis
Ngaphandle kwama-pathogens angenhla, abantu abane-cystic fibrosis cishe banamakholomu "ama-superbugs" noma izidakamizwa ezinamagciwane amaningi . Izidakamizwa eziningi ezingamelana nezidakamizwa (izinhlobo ezingamelana nama-antibiotic amaningi) zibamba amaphaphu omuntu one-cystic fibrosis zithola ukwelashwa kwama-antibiotic ngezifo zamaphaphu, njenge-Pseudomonas.
Ukoloni kanye nokutheleleka ngezidakamizwa ezinokumelana nezidakamizwa kuyesabeka ngoba lezi zinhlobo ziyakwenqaba ukwelashwa ngama-antibiotic avamile.
Kungani Ukuhlanganiswa Ngama-Pseudomonas Kuqala?
Ochwepheshe banemiqondo eminingi noma bacabanga ngokuthi kungani amaphaphu abantu abane-cystic fibrosis ehlanganiswa kakhulu ne-Pseudomonas, kufaka phakathi okulandelayo:
- Ukunciphisa ukuxoxwa kwezomnotho kuhlanganiswe nokungasebenzi kahle kwama-antibacterial peptides
- Ukuzivikela okungaphelele emaphashini ngenxa yamazinga aphansi e-glutathione ne-nitrous oxide
- Ukungena kwehlisa amabhaktheriya ngamaseli emaphaphu
- Izinombolo ezikhulayo ze-bacterial receptors
Asazi ukuthi iyiphi yalezi zindlela ezibaluleke kakhulu ekusunguleni ukoloni lwePseudomonas. Noma kunjalo, kubonakala ukuthi uma i-Pseudomonas ibamba, ukutheleleka okungapheli kuqhubeka.
Abantu abane-cystic fibrosis abahlanganiswa ne-Pseudomonas badinga ukwelashwa kwansuku zonke kanye nokuthekisana ngezikhathi ezithile ezinomthelela wokulwa namagciwane uma isifo singena. Ngeshwa, ngisho nangokwelashwa okunjalo, ukutheleleka kwe-Pseudomonas kuholela ekulahlekelweni komsebenzi wamaphaphu futhi kuholela ekufeni ekugcineni kubantu abaningi nge-cystic fibrosis. Funda kabanzi mayelana ne- Pseudomonas kubantu abane-cystic fibrosis .)
Imithombo
UBoutin, S., no-A. Dalpke. Ukutholakala nokuguquguquka kwe-Airway Microbiotia ekuPhileni okuQala kweziguli zeCystic Fibrosis. I-Pediatrics yamangqamuzana namaselula . 2017. 4 (1): 1.
Huang, Y., noJ. LiPuma. I-microbiome ku-Cystic Fibrosis. Medicine Chest Medicine . 2016. 37 (1): 59-67.
I-Voynow JA, iMascarenhas M, Kelly A, i-Scanlin TF. I-Cystic Fibrosis. Ku: Grippi MA, Elias JA, Fishman JA, Kotloff RM, Pack AI, RM Senior, Siegel MD. ama-eds. I-Fishman's Pulmonary Diseases and Disorders, Uhlelo lwesihlanu . ENew York, NY: McGraw-Hill; 2015.