I-Eosinophils yilezi zinhlobo zegazi elimhlophe elakhiwe emnothweni we-bone okwenza cishe amaphesenti angu-5 enani lamanani amangqamuzana egazi elimhlophe. Ama-eosinophil angasakaza egazini futhi atholakala ngaphandle kwemithambo yegazi kwezinye izitho emzimbeni. Ipheshana lamathumbu (GI) ngokuvamile linenani eliphakeme kakhulu lama-eosinophil ngokuphathelene nezinye izitho.
Umsebenzi we-Eosinophils
I-Eosinophils ivikela umzimba ukubulala amabhaktheriya nama-parasite kodwa kungabangela izinkinga uma zisabela ngokungalungile futhi zibangele ukuguquka komzimba nezinye izimpande zokuvuvukala emzimbeni. Isibonelo, ukudla kokudla kungabangela ama-eosinophil amaningi kakhulu ukuba abuthe emgodini wokugaya, okungabangela izimpawu ezifana nesifo sohudo nokulimala kwamangqamuzana afaka ipheshana le-GI.
I-Eosinophils iyingxenye yesimiso sokuvikela amasosha omzimba, okusho ukuthi "bangakwazi" ukubhubhisa noma yikuphi abahlaseli abahlangana nabo emzimbeni, njengebhaktheriya nama-parasites. Ngokungaqondile kusho ukuthi ama-eosinophil akudingeki aqaphele umhlaseli ngokuqondile, kodwa esikhundleni salokho amane ambone umhlasela njengento engeke ibe khona futhi kufanele ibhujiswe.
Uma Kukhona Ama-Eosinophil amaningi kakhulu
Uma inani elikhulu lama-eosinophil lihanjiswa kusayithi elithile emzimbeni, noma uma umnkantsha we-bone ukhiqiza ama-eosinophil amaningi kakhulu, isimo esaziwa ngokuthi i-eosinophilia ikhona.
I-Eosinophilia ingabangela izimo ezihlukahlukene, izifo, kanye nezici, kubandakanya:
- Izifo eziphazamisayo nezifungalwazi
- Amagciwane
- Izimo ze- Adrenal
- Izifo zesikhumba
- Ubuthi
- Izifo ezizenzakalelayo
- Izinkinga ze-endocrine
Ngaphezu kwalokho, i-eosinophilia ingahlakulela ekuphenduleni amanye amagciwane, kuhlanganise:
- I-Lymphoma (i-Hodgkin's non-Hodgkin's lymphoma).
- I-leukemia (i-chronic myeloid leukemia, i-T-cell edala i-leukemia / i-lymphoma (i-ATLL), i-leukemia ye-eosinophilic)
- Umdlavuza we-Colorectal
- Umdlavuza we-Lung
I-Eosinophils neColorectal Cancer
Inani lama-eosinophil egazini lingakhuphuka ngesikhathi sempendulo evamile ekuphenduleni kwemizwa, ukutheleleka kwamafungal kanye nama-parasitic, imithi kanye nezinye izinhlobo zomdlavuza.
Ucwaningo olwenziwe ngo-2011 olwanyatheliswa kuyi-Journal of Clinical Oncology luhlolisise ubudlelwane phakathi kwama-eosinophil egazini legazi kanye nesifo somdlavuza we-colorectal. Abacwaningi bathola ukuthi inani eliphakeme legazi elingama-eosinophils lihlotshaniswa nenengozi enciphise yokufa ngenxa yomdlavuza omncane, ikakhulukazi ezigulini ezingazange zibheke futhi zibe ngamadoda. Nakuba lolu cwaningo alukwazanga ukuthola indlela yokuchaza lobudlelwane, inkolelo eyodwa ebonakalayo yukuthi amasosha omzimba akhuthele kakhulu anciphisa ingozi yokuthuthukisa umdlavuza we-colorectal.
Esinye isifundo esashicilelwe encwadini ethi Modern Pathology ngo-2014 sabheka indlela ama-eosinophil angase abike ngayo imiphumela yeziguli ezine-cancer yombala. Nakuba isifo somdlavuza obala kakhulu sisekelwe olwazini oluphathelene nesifo sofuba, ukubandakanyeka kwe-lymph node , kanye nokutholakala kwe-metastase (umdlavuza usakazeka kwezinye izingosi), ngokuvamile iziguli ezimbili ezinesimo esifanayo ziyoba nemiphumela ephawulekayo.
Ababhali belo cwaningo bahlola ukuthi amazinga e-eosinophils noma azungeze i-tumor engavamile ayasiza ukubikezela umphumela. Baphetha ngokuthi izinombolo eziphakeme ze-eosinophils ezungeze isisu esiyisisekelo esiyinhloko zazihlotshaniswa nomphumela wesiguli esithuthukisiwe nokuthi kufanele zibalwa njalo ngesikhathi sokuhlolwa kwe-tumor.
Imithombo:
Ukuphila Kwamanje. Sep 12, 2014. "I-Peritumoral eosinophils ibikezela ukuphindaphindiwe emdlalweni we-colorectal."
I-Journal ye-Clinical Oncology. 29: 2011. "I-peripheral blood eosinophil ibala futhi isengozini yokufa komdlavuza we-colorectal ku-general study-based study group."